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A dose ‐escalation study of combretastatin A4‐phosphate in healthy dogs
Combretastatin A4‐Phosphate (CA4P) is a vascular disrupting agent revealing promising results in cancer treatments for humans. The aim of this study was to investigate the safety and adverse events of CA4P in healthy dogs as a prerequisite to application of CA4P in dogs with cancer. Ten healthy dogs were included. The effects of escalating doses of CA4P on physical, haematological and biochemical parameters, systolic arterial blood pressure, electrocardiogram, echocardiographic variables and general wellbeing were characterised. Three different doses were tested: 50, 75 and 100 mg m−2. At all 3 CA4P doses, nausea, ...
Source: Veterinary and Comparative Oncology - June 1, 2017 Category: Veterinary Research Authors: E. Abma, P. Smets, S. Daminet, I. Cornelis, K. De Clercq, Y. Ni, L. Vlerick, H. de Rooster Tags: ORIGINAL ARTICLE Source Type: research

Epirubicin in the treatment of canine histiocytic sarcoma: sequential, alternating and rescue chemotherapy
The aims of this study were to report treatment outcomes for dogs with histiocytic sarcoma (HS) treated with both lomustine and epirubicin, and to report response rates to epirubicin as a rescue therapy in dogs previously treated with lomustine. Medical records of dogs with a diagnosis of HS that were treated with both lomustine and epirubicin were retrospectively evaluated. Of 29 dogs receiving epirubicin alternating with, or subsequent to lomustine treatment, including in a rescue setting, response to epirubicin could be assessed in 20 with an overall response rate (ORR) of 29% and biological response rate (BRR) of 71%. ...
Source: Veterinary and Comparative Oncology - June 1, 2017 Category: Veterinary Research Authors: S. L. Mason, R. Finotello, L. Blackwood Tags: ORIGINAL ARTICLE Source Type: research

Apoptotic intrinsic pathway proteins predict survival in canine cutaneous mast cell tumours
Mast cell tumours (MCTs) are the most frequent canine round cell neoplasms and show variable biological behaviours with high metastatic and recurrence rates. The disease is treated surgically and wide margins are recommended. Adjuvant chemotherapy and radiotherapy used in this disease cause DNA damage in neoplastic cells, which is aimed to induce apoptotic cell death. Resisting cell death is a hallmark of cancer, which contributes to the development and progression of tumours. The aim of this study was to investigate the expression of the proteins involved in the apoptotic intrinsic pathway and to evaluate their potential ...
Source: Veterinary and Comparative Oncology - June 1, 2017 Category: Veterinary Research Authors: C. N. Barra, B. M. Macedo, K. G. Cadrobbi, L. H. Pulz, G. C. Huete, S. R. Kleeb, J. G. Xavier, J. L. Cat ão‐Dias, A. T. Nishiya, H. Fukumasu, R. F. Strefezzi Tags: ORIGINAL ARTICLE Source Type: research

In vitro and in vivo effect of flutamide on steroid hormone secretion in canine and human inflammatory breast cancer cell lines
The aim was to study the effects of flutamide on cell proliferation, in vivo tumour growth and steroid production in canine and human IBC cell lines. IPC‐366 and SUM149 cell cultures were exposed to flutamide concentrations for 72 hours. Additionally, IPC‐366 and SUM149 xenotransplanted mice were treated subcutaneously with flutamide 3 times a week for 2 weeks. Steroid hormones determination in culture media, serum and tumour homogenates (pregnenolone, progesterone, androstenedione, testosterone, dihydrotestosterone, 17β‐oestradiol and oestrone sulphate) were assayed by EIA. in vitro cell proliferation percentages s...
Source: Veterinary and Comparative Oncology - June 1, 2017 Category: Veterinary Research Authors: S. Caceres, B. Monsalve, L. Pe ña, P. J. Andres, A. Alonso‐Diez, M. J. Illera, W. A. Woodward, J. M. Reuben, G. Silvan, J. C. Illera Tags: ORIGINAL ARTICLE Source Type: research

Outcome following treatment of feline gastrointestinal mast cell tumours
Prognosis of feline gastrointestinal mast cell tumours (FGIMCT), based on limited available literature, is described as guarded to poor, which may influence treatment recommendations and patient outcome. The purpose of this study is to describe the clinical findings, treatment response, and outcome of FGIMCT. Medical records of 31 cats diagnosed with and treated for FGIMCT were retrospectively reviewed. Data collected included signalment, method of diagnosis, tumour location (including metastatic sites), treatment type, cause of death and survival time. Mean age was 12.9 y. Diagnosis was made via cytology (n = 15), h...
Source: Veterinary and Comparative Oncology - May 31, 2017 Category: Veterinary Research Authors: L. E. Barrett, K. Skorupski, D. C. Brown, N. Weinstein, C. Clifford, A. Szivek, S. Haney, S. Kraiza, E. L. Krick Tags: ORIGINAL ARTICLE Source Type: research

Outcome following treatment of feline gastrointestinal mast cell tumours
Veterinary and Comparative Oncology, EarlyView. (Source: Veterinary and Comparative Oncology)
Source: Veterinary and Comparative Oncology - May 31, 2017 Category: Veterinary Research Source Type: research

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Veterinary and Comparative Oncology, Ahead of Print. (Source: Veterinary and Comparative Oncology)
Source: Veterinary and Comparative Oncology - May 31, 2017 Category: Veterinary Research Source Type: research

Feline large granular lymphocyte lymphoma: An Italian Society of Veterinary Oncology (SIONCOV) retrospective study
Feline large granular lymphocyte (LGL) lymphoma is an uncommon subtype of lymphoma characterized by a grave prognosis and scarce response to chemotherapy. There are limited reports on clinico‐pathological and prognostic factors. One‐hundred and 9 cats with newly diagnosed LGL lymphoma that underwent initial staging (including hematology, serum biochemistry, thoracic radiographs and abdominal ultrasound), and followed‐up were retrospectively evaluated. LGL lymphoma was localized within the gastrointestinal tract with or without extra‐intestinal involvement in 91.7% of the cases, and at extra‐gastrointestinal sites...
Source: Veterinary and Comparative Oncology - May 29, 2017 Category: Veterinary Research Authors: R. Finotello, M. E. Vasconi, S. Sabattini, C. Agnoli, C. Giacoboni, M. Annoni, A. Dentini, G. Bettini, P. Guazzi, D. Stefanello, E. Bottero, P. Mesto, R. Marinelli, C. De Feo, L. Marconato Tags: ORIGINAL ARTICLE Source Type: research

Feline large granular lymphocyte lymphoma: An Italian Society of Veterinary Oncology (SIONCOV) retrospective study
Veterinary and Comparative Oncology,Volume 16, Issue 1, Page 159-166, March 2018. (Source: Veterinary and Comparative Oncology)
Source: Veterinary and Comparative Oncology - May 29, 2017 Category: Veterinary Research Source Type: research

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Veterinary and Comparative Oncology,Volume 16, Issue 1, Page 159-166, March 2018. (Source: Veterinary and Comparative Oncology)
Source: Veterinary and Comparative Oncology - May 29, 2017 Category: Veterinary Research Source Type: research

Comparison of histologic margin status in low ‐grade cutaneous and subcutaneous canine mast cell tumours examined by radial and tangential sections
ConclusionThese data indicate that for low grade MCTs, HTFMs >0 mm should not be considered completely excised, particularly when HTFM is <10.9 mm. This will inform future studies that use HTFM and overall excisional status as dependent variables in multivariable prognostic models. (Source: Veterinary and Comparative Oncology)
Source: Veterinary and Comparative Oncology - May 23, 2017 Category: Veterinary Research Authors: C.B. Dores, M. Milovancev, D.S. Russell Tags: ORIGINAL ARTICLE Source Type: research

Comparison of histologic margin status in low ‐grade cutaneous and subcutaneous canine mast cell tumours examined by radial and tangential sections
Veterinary and Comparative Oncology,Volume 16, Issue 1, Page 125-130, March 2018. (Source: Veterinary and Comparative Oncology)
Source: Veterinary and Comparative Oncology - May 23, 2017 Category: Veterinary Research Source Type: research

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Veterinary and Comparative Oncology,Volume 16, Issue 1, Page 125-130, March 2018. (Source: Veterinary and Comparative Oncology)
Source: Veterinary and Comparative Oncology - May 23, 2017 Category: Veterinary Research Source Type: research

Metastatic diagnosis of canine sternal lymph nodes using computed tomography characteristics: A retrospective cross ‐sectional study
The accurate evaluation of sternal lymph nodes (StLNs) is critical for the staging of canine thoraco‐abdominal tumours. Computed tomography (CT) provides a non‐invasive means of assessing StLNs, but its diagnostic accuracy for identifying metastases is unclear. In this retrospective cross‐sectional study, we assessed the diagnostic power of various CT measurements. Fifty‐seven dogs that underwent concurrent CT and cytological examination of the StLNs were enrolled retrospectively. The size, shape, X‐ray attenuation and uniformity of the StLNs were assessed. The dogs were divided into metastasis‐negative (n =...
Source: Veterinary and Comparative Oncology - May 19, 2017 Category: Veterinary Research Authors: R. Iwasaki, M. Murakami, M. Kawabe, K. Heishima, H. Sakai, T. Mori Tags: ORIGINAL ARTICLE Source Type: research

Metastatic diagnosis of canine sternal lymph nodes using computed tomography characteristics: A retrospective cross ‐sectional study
Veterinary and Comparative Oncology,Volume 16, Issue 1, Page 140-147, March 2018. (Source: Veterinary and Comparative Oncology)
Source: Veterinary and Comparative Oncology - May 19, 2017 Category: Veterinary Research Source Type: research