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Common germline haplotypes and genotypes identified in BRCA2 exon 11 of dogs with Mammary Tumors and histopathological analyses
Veterinary and Comparative Oncology, EarlyView. (Source: Veterinary and Comparative Oncology)
Source: Veterinary and Comparative Oncology - March 6, 2018 Category: Veterinary Research Source Type: research

Survival analysis of dogs with advanced primary lung carcinoma treated by metronomic cyclophosphamide, piroxicam and thalidomide
Veterinary and Comparative Oncology, EarlyView. (Source: Veterinary and Comparative Oncology)
Source: Veterinary and Comparative Oncology - March 6, 2018 Category: Veterinary Research Source Type: research

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Veterinary and Comparative Oncology, Ahead of Print. (Source: Veterinary and Comparative Oncology)
Source: Veterinary and Comparative Oncology - March 6, 2018 Category: Veterinary Research Source Type: research

Does the tumour microenvironment alter tumorigenesis and clinical response in transmissible venereal tumour in dogs?
Veterinary and Comparative Oncology, EarlyView. (Source: Veterinary and Comparative Oncology)
Source: Veterinary and Comparative Oncology - March 5, 2018 Category: Veterinary Research Source Type: research

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Veterinary and Comparative Oncology, Ahead of Print. (Source: Veterinary and Comparative Oncology)
Source: Veterinary and Comparative Oncology - March 5, 2018 Category: Veterinary Research Source Type: research

Does the tumour microenvironment alter tumorigenesis and clinical response in transmissible venereal tumour in dogs?
The canine transmissible venereal tumour (CTVT) is a transmissible cancer that is spread naturally between dogs, with the ability to develop and evade the immune system, despite strict immune surveillance of the host. Furthermore, molecular signalling between cells of the immune system and the tumour microenvironment appear to influence the behaviour and development of the tumour. Thus, this study aimed to quantify the expression of genes related to the immune system such as IL‐6, IFN‐γ, and TGF‐β, as well as angiogenic factors (VEGF, CXCR4), in CTVT cells in vivo and in vitro (primary culture), correlating with th...
Source: Veterinary and Comparative Oncology - March 5, 2018 Category: Veterinary Research Authors: H. Ballestero F êo, L. Montoya Flórez, R. S. Yamatogi, A. Prado Duzanski, J. P. Araújo, R. A. Oliveira, N. S. Rocha Tags: ORIGINAL ARTICLE Source Type: research

Inter ‐ and intra‐rater reliability and agreement in determining subcutaneous tumour margins in dogs
Veterinary and Comparative Oncology, EarlyView. (Source: Veterinary and Comparative Oncology)
Source: Veterinary and Comparative Oncology - March 1, 2018 Category: Veterinary Research Source Type: research

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Veterinary and Comparative Oncology, Ahead of Print. (Source: Veterinary and Comparative Oncology)
Source: Veterinary and Comparative Oncology - March 1, 2018 Category: Veterinary Research Source Type: research

Prognostic significance of hypermethylation of death ‐associated protein kinase (DAPK) gene CpG island in dogs with high‐grade B‐cell lymphoma
Death‐associated protein kinase (DAPK) is a serine/threonine kinase and a tumour suppressor gene. Diffuse large B‐cell lymphomas with inactivated DAPK through hypermethylation of a CpG island is known to result in a biologically aggressive phenotype in humans. This retrospective study was carried out to analyse the prognostic significance of DAPK CpG island hypermethylation in canine lymphoma. We hypothesized that DAPK CpG island hypermethylation can be a negative prognostic indicator in dogs with nodal high‐grade B‐cell lymphoma. Forty‐seven dogs with high‐grade B‐cell lymphoma, according to the updated Kiel...
Source: Veterinary and Comparative Oncology - March 1, 2018 Category: Veterinary Research Authors: M. Sato, H. Mochizuki, Y. Goto ‐Koshino, A. Fujiwara‐Igarashi, M. Takahashi, K. Ohno, H. Tsujimoto Tags: ORIGINAL ARTICLE Source Type: research

Common germline haplotypes and genotypes identified in BRCA2 exon 11 of dogs with Mammary Tumors and histopathological analyses
The canine BRCA2 is a tumor supressor gene which encodes the BRCA2 protein, involved in DNA repair through interaction with the RAD51 recombinase. This process is mediated by eigth BRC repeats that are encoded by BRCA2 exon 11. Two variants corresponding to human mutations in human BRC3 repeat have been reported in canine BRC3 repeat. In addition, other variants have also been described in canine BRCA2 exon 11. Considering the importance of polymorphisms in human BRCA2 to breast cancer development, this study aimed to investigate the frequency of variants in BRCA2 exon 11 in 48 blood and tissue DNA samples from bitches wit...
Source: Veterinary and Comparative Oncology - March 1, 2018 Category: Veterinary Research Authors: T. Mau és, K. B. El‐Jaick, F. B. Costa, G. E. F. Araujo, M. V. G. Soares, A. S. Moreira, M. L. G. Ferreira, A. M. R. Ferreira Tags: ORIGINAL ARTICLE Source Type: research

Survival analysis of dogs with advanced primary lung carcinoma treated by metronomic cyclophosphamide, piroxicam and thalidomide
This study was undertaken to explore the impact of metronomic chemotherapy (MC) in dogs with advanced PPC. Previously untreated dogs with advanced (T3 or N1 or M1) PPC, with complete staging work‐up and follow‐up data, receiving MC (comprising low‐dose cyclophosphamide, piroxicam and thalidomide), surgery, MTD chemotherapy or no oncologic treatment were eligible for inclusion. For all patients, time to progression (TTP) and survival time (ST) were evaluated. Quality‐of‐life (QoL) was only evaluated in patients receiving MC. To assess QoL, owners of dogs receiving MC were asked to complete a questionnaire before a...
Source: Veterinary and Comparative Oncology - March 1, 2018 Category: Veterinary Research Authors: G. Polton, R. Finotello, S. Sabattini, F. Rossi, P. Laganga, M. E. Vasconi, A. Barbanera, K. Stiborova, C. Rohrer Bley, L. Marconato Tags: ORIGINAL ARTICLE Source Type: research

Inter ‐ and intra‐rater reliability and agreement in determining subcutaneous tumour margins in dogs
The objective of this prospective study was to evaluate agreement and reliability of calliper‐based measurements of locally invasive subcutaneous malignant tumours in dogs. Four raters measured the longest diameter of 12 subcutaneous tumours (7 soft tissue sarcomas and 5 mast cell tumours) from 11 client‐owned dogs during 3 randomized, blinded measurement trials, both pre‐ and post‐sedation. Inter‐ and intra‐rater reliability was evaluated using intra‐class correlation coefficient (ICC) and agreement was evaluated using Bland‐Altman plots. Inter‐ and intra‐rater reliability was good (ICC range of 0.8694...
Source: Veterinary and Comparative Oncology - March 1, 2018 Category: Veterinary Research Authors: B. Ranganathan, M. Milovancev, H. Leeper, K. L. Townsend, S. Bracha, K. Curran Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
Veterinary and Comparative Oncology,Volume 16, Issue 1, March 2018. (Source: Veterinary and Comparative Oncology)
Source: Veterinary and Comparative Oncology - February 21, 2018 Category: Veterinary Research Source Type: research

Cover Image, Volume 16, Issue 1
Veterinary and Comparative Oncology,Volume 16, Issue 1, Page i-i, March 2018. (Source: Veterinary and Comparative Oncology)
Source: Veterinary and Comparative Oncology - February 21, 2018 Category: Veterinary Research Source Type: research