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Diagnostic accuracy of pre ‐treatment biopsy for grading cutaneous mast cell tumours in dogs
Mast cell tumours (MCTs) are common tumours of the canine skin, and are estimated to represent up to 20% of all skin tumours in dogs. Tumour grade has a major impact on the incidence of local recurrence and metastatic potential. In addition to helping the clinician with surgical planning, knowledge of the tumour grade also assists in proper prognostication and client education. For pre‐treatment biopsies to be useful, there must exist a high level of correlation between the histopathological grade obtained from the pre‐treatment biopsy and the actual histopathological grade from the excisional biopsy. The aim of this s...
Source: Veterinary and Comparative Oncology - August 31, 2017 Category: Veterinary Research Authors: T. Shaw, S. T. Kudnig, S. M. Firestone Tags: ORIGINAL ARTICLE Source Type: research

Principles for ethical treatment decision ‐making in veterinary oncology
Veterinary and Comparative Oncology, EarlyView. (Source: Veterinary and Comparative Oncology)
Source: Veterinary and Comparative Oncology - August 31, 2017 Category: Veterinary Research Source Type: research

Diagnostic accuracy of pre ‐treatment biopsy for grading cutaneous mast cell tumours in dogs
Veterinary and Comparative Oncology, EarlyView. (Source: Veterinary and Comparative Oncology)
Source: Veterinary and Comparative Oncology - August 31, 2017 Category: Veterinary Research Source Type: research

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Veterinary and Comparative Oncology, Ahead of Print. (Source: Veterinary and Comparative Oncology)
Source: Veterinary and Comparative Oncology - August 31, 2017 Category: Veterinary Research Source Type: research

Principles for ethical treatment decision ‐making in veterinary oncology
Many owners of companion animals with cancer are overwhelmed by having to choose the “right course of action.” With the aim of reducing the burden on owners who are forced to act as surrogates for their animals, this work discusses principles that apply to ethical treatment decision‐making for animal patients with cancer. Four principles frequently used for ethical decision‐making in human medicine will be considered for their potential applicability in veterinary medicine. As a result of these considerations, preliminary guidelines are presented, along which a decision‐making discussion can be held. The delibera...
Source: Veterinary and Comparative Oncology - August 31, 2017 Category: Veterinary Research Authors: C. Rohrer Bley Tags: REVIEW ARTICLE Source Type: research

Characterization of a low expression haplotype in canine glutathione S ‐transferase (GSTT1) and its prevalence in golden retrievers
Glutathione S‐transferase‐theta (GSTT1) is a carcinogen detoxification enzyme, and low activity variants are associated with lymphoma in humans. We recently found a variant in the 3′ untranslated region (UTR) of canine GSTT1, *101_102insT, which was predicted to change miRNA binding and was found in 5 of 17 golden retriever (GR) dogs with lymphoma but none of 14 healthy GRs. The aim of this study was to determine whether this variant led to decreased GSTT1 expression and was a discernible risk factor for lymphoma within the GR breed. On resequencing, *101_102insT appeared to be in complete linkage disequilibrium with...
Source: Veterinary and Comparative Oncology - August 25, 2017 Category: Veterinary Research Authors: S. Craft, J. Ekena, B. Mayer, D. H. Thamm, C. Saba, R. Chun, L. A. Trepanier Tags: ORIGINAL ARTICLE Source Type: research

Characterization of a low expression haplotype in canine glutathione S ‐transferase (GSTT1) and its prevalence in golden retrievers
Veterinary and Comparative Oncology,Volume 16, Issue 1, Page E61-E67, March 2018. (Source: Veterinary and Comparative Oncology)
Source: Veterinary and Comparative Oncology - August 25, 2017 Category: Veterinary Research Source Type: research

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Veterinary and Comparative Oncology,Volume 16, Issue 1, Page E61-E67, March 2018. (Source: Veterinary and Comparative Oncology)
Source: Veterinary and Comparative Oncology - August 25, 2017 Category: Veterinary Research Source Type: research

Prior joint disease is associated with increased risk of periarticular histiocytic sarcoma in dogs
This study confirms that the previously noted association between prior joint disease and PAHS in Bernese Mountain Dogs also applies to other breeds. Additional studies are needed to further investigate for a causal relationship. (Source: Veterinary and Comparative Oncology)
Source: Veterinary and Comparative Oncology - August 24, 2017 Category: Veterinary Research Authors: E. K. Manor, L. E. Craig, X. Sun, C. M. Cannon Tags: ORIGINAL ARTICLE Source Type: research

Prior joint disease is associated with increased risk of periarticular histiocytic sarcoma in dogs
Veterinary and Comparative Oncology,Volume 16, Issue 1, Page E83-E88, March 2018. (Source: Veterinary and Comparative Oncology)
Source: Veterinary and Comparative Oncology - August 23, 2017 Category: Veterinary Research Source Type: research

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Veterinary and Comparative Oncology,Volume 16, Issue 1, Page E83-E88, March 2018. (Source: Veterinary and Comparative Oncology)
Source: Veterinary and Comparative Oncology - August 23, 2017 Category: Veterinary Research Source Type: research

Transcriptomic profile reveals molecular events associated to focal adhesion and invasion in canine mammary gland tumour cell lines
The prevalence of cancer in animals has increased significantly over the years. Mammary tumours are the most common neoplasia in dogs, in which around 50% are presented in the malignant form. Hence, the development and characterization of in vitro models for the study of canine tumours are important for the improvement of cancer diagnosis and treatment. Thus, the aim of this study was to characterize cell lines derived from canine mammary gland neoplasias which could be further used for basic and applied oncology research. Samples of canine mammary carcinomas were taken for cell culture and 2 cell lines were established an...
Source: Veterinary and Comparative Oncology - August 18, 2017 Category: Veterinary Research Authors: Y. G. Cordeiro, P. L. P. Xavier, A. L. Rochetti, P. A. Alexandre, C. M. C. Mori, R. F. Strefezzi, H. Fukumasu Tags: ORIGINAL ARTICLE Source Type: research

Transcriptomic profile reveals molecular events associated to focal adhesion and invasion in canine mammary gland tumour cell lines
Veterinary and Comparative Oncology,Volume 16, Issue 1, Page E89-E98, March 2018. (Source: Veterinary and Comparative Oncology)
Source: Veterinary and Comparative Oncology - August 18, 2017 Category: Veterinary Research Source Type: research

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Veterinary and Comparative Oncology,Volume 16, Issue 1, Page E89-E98, March 2018. (Source: Veterinary and Comparative Oncology)
Source: Veterinary and Comparative Oncology - August 18, 2017 Category: Veterinary Research Source Type: research