Bosutinib, an SRC inhibitor, induces caspase ‐independent cell death associated with permeabilization of lysosomal membranes in melanoma cells

ConclusionOur data suggest that Bosu induces the cell death through induction of LMP in melanoma cells and is a promising therapeutic agent for treatment of melanoma in both dogs and humans.

Source: Veterinary and Comparative Oncology - March 1, 2017 Category: Veterinary Research Authors: S. Noguchi, S. Shibutani, K. Fukushima, T. Mori, M. Igase, T. Mizuno Tags: ORIGINAL ARTICLE Source Type: research