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Novel Insights into Sensorimotor and Cardiovascular Autonomic Neuropathy from Recent-Onset Diabetes and Population-Based Cohorts
Publication date: Available online 30 March 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Christian Herder, Michael Roden, Dan ZieglerThe most prevalent chronic complications of diabetes are diabetic neuropathies, among which distal sensorimotor polyneuropathy (DSPN) and cardiovascular autonomic neuropathy (CAN) are the best studied. Their major clinical sequelae such as foot ulcers, neuropathic pain, and orthostatic hypotension are associated with lower quality of life and increased risk of mortality. Here we discuss the recent insights into DSPN and CAN focusing on two prospective cohorts; that is, the Germa...
Source: Trends in Endocrinology and Metabolism - March 30, 2019 Category: Endocrinology Source Type: research

Reactive Oxygen Comes of Age: Mechanism-Based Therapy of Diabetic End-Organ Damage
Publication date: Available online 27 March 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Mahmoud H. Elbatreek, Mayra P. Pachado, Antonio Cuadrado, Karin Jandeleit-Dahm, Harald H.H.W. SchmidtReactive oxygen species (ROS) have been mainly viewed as unwanted by-products of cellular metabolism, oxidative stress, a sign of a cellular redox imbalance, and potential disease mechanisms, such as in diabetes mellitus (DM). Antioxidant therapies, however, have failed to provide clinical benefit. This paradox can be explained by recent discoveries that ROS have mainly essential signaling and metabolic functions and evolu...
Source: Trends in Endocrinology and Metabolism - March 28, 2019 Category: Endocrinology Source Type: research

Common Fatty Markers in Diseases with Dysregulated Lipogenesis
Publication date: Available online 26 March 2019Source: Trends in Endocrinology & MetabolismAuthor(s): David Balgoma, Curt Pettersson, Mikael HedelandRecent studies have reported the upregulation of a subgroup of triacylglycerides as markers of different diseases with dysregulated lipogenesis, which means that these markers are not selective. This observation has a deep impact on their use as diagnostic tools in clinical practice (e.g., markers of risk of type 2 diabetes). (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - March 28, 2019 Category: Endocrinology Source Type: research

Editorial Board and Contents
Publication date: April 2019Source: Trends in Endocrinology & Metabolism, Volume 30, Issue 4Author(s): (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - March 15, 2019 Category: Endocrinology Source Type: research

Combined Antioxidant and Glucocorticoid Therapy for Safer Treatment of Preterm Birth
Publication date: Available online 5 March 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Tessa A.C. Garrud, Dino A. GiussaniAnte- and postnatal glucocorticoid therapy reduces morbidity and mortality in the preterm infant, and it is therefore one of the best examples of the successful translation of basic experimental science into human clinical practice. However, accruing evidence derived from human clinical studies and from experimental studies in animal models raise serious concerns about potential long-term adverse effects of treatment on growth and neurological and cardiovascular function in the offspring....
Source: Trends in Endocrinology and Metabolism - March 6, 2019 Category: Endocrinology Source Type: research