Combined Antioxidant and Glucocorticoid Therapy for Safer Treatment of Preterm Birth

Publication date: Available online 5 March 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Tessa A.C. Garrud, Dino A. GiussaniAnte- and postnatal glucocorticoid therapy reduces morbidity and mortality in the preterm infant, and it is therefore one of the best examples of the successful translation of basic experimental science into human clinical practice. However, accruing evidence derived from human clinical studies and from experimental studies in animal models raise serious concerns about potential long-term adverse effects of treatment on growth and neurological and cardiovascular function in the offspring. This review explores whether combined antioxidant and glucocorticoid therapy may be safer than glucocorticoid therapy alone for the treatment of preterm birth.
Source: Trends in Endocrinology and Metabolism - Category: Endocrinology Source Type: research