Trends in Endocrinology and Metabolism 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Hormesis in Health and Chronic Diseases
Publication date: Available online 11 September 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Xin Li, Tingting Yang, Zheng Sun‘What doesn’t kill you makes you stronger’. Hormesis, the paradoxical beneficial effects of low-dose stressors, can be better defined as the biphasic dose–effect or time–effect relationship for any substance. Here we review hormesis-like phenomena in the context of chronic diseases for many substances, including lifestyle factors and endocrine factors. Intermittent or pulsatile exposure can generate opposite effects compared with continuous exposure. An initial exposure can el...
Source: Trends in Endocrinology and Metabolism - September 11, 2019 Category: Endocrinology Source Type: research
Maternal Microbiome and Metabolic Health Program Microbiome Development and Health of the Offspring
Publication date: Available online 5 September 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Marta Calatayud, Omry Koren, Maria Carmen ColladoMaternal nutritional, metabolic, and physiological states, as well as exposure to various environmental factors during conception, gestation, and lactation, have a fundamental role in the health programming of the offspring. Therefore, alterations affecting the maternal microbiota might indirectly influence fetal development. In addition, such alterations could be transmitted to the progeny at different stages of infant development (e.g., preconception, prenatal, or post...
Source: Trends in Endocrinology and Metabolism - September 5, 2019 Category: Endocrinology Source Type: research
Hypothalamic Heuristics for Survival
Publication date: Available online 3 September 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Denis Burdakov, Daria Peleg-RaibsteinHypothalamic neurons implicated in energy homeostasis (Agrp, POMC, orexin, MCH) display fast, nutrient-independent dynamics. They do not simply mirror the slowly changing internal nutrient levels, but adapt rapidly to diverse external cues. Moreover, instead of eating, neonatal Agrp cells stimulate mother-attracting vocalisations, illustrating heuristic energy control beyond nutrient sensing or dietary self-control. (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - September 5, 2019 Category: Endocrinology Source Type: research
Lots of Movement in Gut and Parkinson’s Research
Publication date: Available online 28 August 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Gabriela Mercado, Patrik BrundinA new mouse model of Parkinson’s disease (PD) demonstrates α-synuclein pathology spreading from the gut to the brain via the vagus nerve (Kim et al., Neuron, 2019). The pathology is associated with motor and non-motor behavioral deficits in wild-type mice. These findings support the idea that the gut could be a starting point for PD. (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - August 29, 2019 Category: Endocrinology Source Type: research
Hypogonadism in Pediatric Health: Adult Medicine Concepts Fail
Publication date: Available online 27 August 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Romina P. Grinspon, Analía V. Freire, Rodolfo A. ReyThe classical definition of hypogonadism, used in adult medicine, as gonadal failure resulting in deficient steroid and gamete production, and its classification into hypergonadotropic and hypogonadotropic refer to primary gonadal and hypothalamic–pituitary disorders respectively and may lead to under- or misdiagnosis in pediatrics. Indeed, in children with primary gonadal failure, gonadotropin levels may be within the reference range for age. Conversely, since gonad...
Source: Trends in Endocrinology and Metabolism - August 28, 2019 Category: Endocrinology Source Type: research
ER Stress Priming of Mitochondrial Respiratory suPERKomplex Assembly
Publication date: Available online 24 August 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Ruben Quintana-Cabrera, Maria Eugenia SorianoAssembly factors are necessary for the formation of mitochondrial supercomplexes (SCs) and in making cellular respiration more efficient. In a recent study, Balsa et al. (Mol. Cell, 2019) report that nutrient-induced endoplasmic reticulum (ER) stress engages PERK–eIF2α-mediated transcription of the SCs assembly factor SCAF1, events that coordinate ER stress and SCs formation to improve bioenergetics. (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - August 25, 2019 Category: Endocrinology Source Type: research
Ghrelin-Mediated Hippocampal Neurogenesis: Implications for Health and Disease
Publication date: Available online 21 August 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Luke Buntwal, Martina Sassi, Alwena H. Morgan, Zane B. Andrews, Jeffrey S. DaviesThere is a close relationship between cognition and nutritional status, however, the mechanisms underlying this relationship require elucidation. The stomach hormone, ghrelin, which is released during food restriction, provides a link between circulating energy state and adaptive brain function. The maintenance of such homeostatic systems is essential for an organism to thrive and survive, and accumulating evidence points to ghrelin being ke...
Source: Trends in Endocrinology and Metabolism - August 22, 2019 Category: Endocrinology Source Type: research
Editorial Board
Publication date: September 2019Source: Trends in Endocrinology & Metabolism, Volume 30, Issue 9Author(s): (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - August 21, 2019 Category: Endocrinology Source Type: research
The FoxO–Autophagy Axis in Health and Disease
Publication date: September 2019Source: Trends in Endocrinology & Metabolism, Volume 30, Issue 9Author(s): Zhiyong ChengAutophagy controls cellular remodeling and quality control. Dysregulated autophagy has been implicated in several human diseases including obesity, diabetes, cardiovascular disease, neurodegenerative diseases, and cancer. Current evidence has revealed that FoxO (forkhead box class O) transcription factors have a multifaceted role in autophagy regulation and dysregulation. Nuclear FoxOs transactivate genes that control the formation of autophagosomes and their fusion with lysosomes. Independently of transa...
Source: Trends in Endocrinology and Metabolism - August 21, 2019 Category: Endocrinology Source Type: research
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Publication date: September 2019Source: Trends in Endocrinology & Metabolism, Volume 30, Issue 9Author(s): (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - August 21, 2019 Category: Endocrinology Source Type: research
Are Lifestyle Therapies Effective for NAFLD Treatment?
Publication date: Available online 15 August 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Nermeen N. El-Agroudy, Anica Kurzbach, Roman N. Rodionov, John O’Sullivan, Michael Roden, Andreas L. Birkenfeld, Dominik H. PestaNonalcoholic fatty liver disease (NAFLD) is becoming the most common liver disorder worldwide. Specifically, nonalcoholic steatohepatitis (NASH) and fibrosis pose an enormous burden for patients and health-care systems. In the absence of approved pharmacological therapies, effective lifestyle interventions for NAFLD, such as dietary strategies and exercise training, are currently the therapeu...
Source: Trends in Endocrinology and Metabolism - August 17, 2019 Category: Endocrinology Source Type: research
Impact of Circadian Disruption on Cardiovascular Function and Disease
Publication date: Available online 16 August 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Sarah L. Chellappa, Nina Vujovic, Jonathan S. Williams, Frank A.J.L. ScheerThe circadian system, that is ubiquitous across species, generates ~24 h rhythms in virtually all biological processes, and allows them to anticipate and adapt to the 24 h day/night cycle, thus ensuring optimal physiological function. Epidemiological studies show time-of-day variations in adverse cardiovascular (CV) events, and controlled laboratory studies demonstrate a circadian influence on key markers of CV function and risk. Furthermore, circ...
Source: Trends in Endocrinology and Metabolism - August 17, 2019 Category: Endocrinology Source Type: research
Lipid Regulators of Thermogenic Fat Activation
Publication date: Available online 16 August 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Hongsuk Park, Anyuan He, Irfan J. LodhiThe global prevalence of obesity continues to increase, suggesting a need for alternative treatment approaches. Targeting brown fat function to promote energy expenditure represents one such approach. Brown adipocytes and the related beige adipocytes oxidize fatty acids and glucose to generate heat and are activated by cold exposure or consumption of high-calorie diets. Alternative, more practical means to activate thermogenic fat are needed. Here, we review emerging data suggesting...
Source: Trends in Endocrinology and Metabolism - August 17, 2019 Category: Endocrinology Source Type: research
Handling Parathormone Receptor Type 1 in Skeletal Diseases: Realities and Expectations of Abaloparatide
Publication date: Available online 11 August 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Juan A. Ardura, Sergio Portal-Núñez, Verónica Alonso, Beatriz Bravo, Arancha R. GortazarMusculoskeletal disorders represent an elevated socioeconomic burden for developed aging societies. Osteoporosis (OP) has been treated with antiresorptive therapies or with teriparatide that was until recently the only anabolic therapy. However, approval of osteoporosis treatment in postmenopausal women with abaloparatide, which is an analog of parathyroid hormone-related peptide (PTHrP), has created a new alternative for OP manage...
Source: Trends in Endocrinology and Metabolism - August 11, 2019 Category: Endocrinology Source Type: research
Metformin as Anti-Aging Therapy: Is It for Everyone?
Publication date: Available online 9 August 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Alexander A. Soukas, Haibin Hao, Lianfeng WuMetformin is the most widely prescribed oral hypoglycemic medication for type 2 diabetes worldwide. Metformin also retards aging in model organisms and reduces the incidence of aging-related diseases such as neurodegenerative disease and cancer in humans. In spite of its widespread use, the mechanisms by which metformin exerts favorable effects on aging remain largely unknown. Further, not all individuals prescribed metformin derive the same benefit and some develop side effects...
Source: Trends in Endocrinology and Metabolism - August 11, 2019 Category: Endocrinology Source Type: research
