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Melatonin Effects on Glucose Metabolism: Time To Unlock the Controversy
Publication date: Available online 1 January 2020Source: Trends in Endocrinology & MetabolismAuthor(s): Marta Garaulet, Jingyi Qian, Jose C. Florez, Josephine Arendt, Richa Saxena, Frank A.J.L. ScheerThe past decade has witnessed a revival of interest in the hormone melatonin, partly attributable to the discovery that genetic variation in MTNR1B – the melatonin receptor gene – is a risk factor for impaired fasting glucose and type 2 diabetes (T2D). Despite intensive investigation, there is considerable confusion and seemingly conflicting data on the metabolic effects of melatonin and MTNR1B variation, and disagreement ...
Source: Trends in Endocrinology and Metabolism - January 1, 2020 Category: Endocrinology Source Type: research

Editorial Board and Contents
Publication date: January 2020Source: Trends in Endocrinology & Metabolism, Volume 31, Issue 1Author(s): (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - December 24, 2019 Category: Endocrinology Source Type: research

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Publication date: January 2020Source: Trends in Endocrinology & Metabolism, Volume 31, Issue 1Author(s): (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - December 24, 2019 Category: Endocrinology Source Type: research

Metabolism, Epigenetics, and Causal Inference in Heart Failure
Publication date: Available online 19 December 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Todd H. Kimball, Thomas M. VondriskaEukaryotes must balance the metabolic and cell death actions of mitochondria via control of gene expression and cell fate by chromatin, thereby functionally binding the metabolome and epigenome. This interaction has far-reaching implications for chronic diseases in humans, the most common of which are those of the cardiovascular system. The most devastating consequence of cardiovascular disease, heart failure, is not a single disease, diagnosis, or endpoint. Human and animal studies ...
Source: Trends in Endocrinology and Metabolism - December 21, 2019 Category: Endocrinology Source Type: research

Uterine Luminal Epithelium as the Transient Gateway for Embryo Implantation
Publication date: Available online 20 December 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Xiaoqin YeThe uterine luminal epithelium (LE) is the first maternal contact for an implanting embryo. Intrauterine fluid resorption, cessation of LE proliferation and apoptosis, and LE structural changes are prerequisites for establishing transient uterine receptivity for embryo implantation. Vesicle trafficking in the LE and receptor-mediated paracrine and autocrine mechanisms are crucial both for LE preparation and LE communications with the embryo and stroma during the initiation of embryo implantation. This review ...
Source: Trends in Endocrinology and Metabolism - December 21, 2019 Category: Endocrinology Source Type: research

Science and Health Policies to Tackle Chronic Diseases in Chile
Publication date: Available online 16 December 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Claudia Bambs, Roberto Bravo-Sagua, Paula Margozzini, Sergio LavanderoChile has experienced rapid epidemiological transitions characterized by decreasing infant mortality, population aging, and a shift towards obesity with an increase in noncommunicable diseases (NCDs). Today, tobacco, alcohol, and ultraprocessed foods are the main risk factors for these diseases. Based on Chile’s experience in tobacco control, we discuss paths to make progress in population evidence-based strategies to improve overall community heal...
Source: Trends in Endocrinology and Metabolism - December 18, 2019 Category: Endocrinology Source Type: research

Mineralocorticoid Receptors in Metabolic Syndrome: From Physiology to Disease
Publication date: Available online 14 December 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Alessandra Feraco, Vincenzo Marzolla, Angelo Scuteri, Andrea Armani, Massimiliano CaprioOver the past decade, several studies have shown that activity of extra-renal mineralocorticoid receptors (MR) regulates vascular tone, adipogenesis, adipose tissue function, and cardiomyocyte contraction. In mice, abnormal activation of MR in the vasculature and in adipose tissue favors the occurrence of several components of the metabolic syndrome (MetS), such as hypertension, obesity, and glucose intolerance. Accordingly, high le...
Source: Trends in Endocrinology and Metabolism - December 15, 2019 Category: Endocrinology Source Type: research

Endocrinological Toxicity Secondary to Treatment of Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NENs)
Publication date: Available online 12 December 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Krystallenia I. Alexandraki, Kosmas Daskalakis, Marina Tsoli, Ashley B. Grossman, Gregory A. KaltsasGastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are increasingly recognized, characterized by prolonged survival even with metastatic disease. Their medical treatment is complex involving various specialties, necessitating awareness of treatment-related adverse effects (AEs). As GEP-NENs express somatostatin receptors (SSTRs), long-acting somatostatin analogs (SSAs) that are used for secretory syndrome and tum...
Source: Trends in Endocrinology and Metabolism - December 13, 2019 Category: Endocrinology Source Type: research

Role of Lipoproteins in the Microenvironment of Hormone-Dependent Cancers
Publication date: Available online 11 December 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Monica GomaraschiThe tumor microenvironment (TME) is an attractive target to develop novel strategies for hormone-dependent cancers. Several molecules in the TME can favor tumor development and progression, including lipoproteins. Lipoproteins are taken up by cancer cells, providing them with cholesterol and fatty acids. Cholesterol regulates cell signaling and it is converted into a series of bioactive metabolites, including hormones. The conflicting results of epidemiological and interventional studies suggest that t...
Source: Trends in Endocrinology and Metabolism - December 12, 2019 Category: Endocrinology Source Type: research

Reducing Type 1 Diabetes Mortality: Role for Adjunctive Therapies?
Publication date: Available online 7 December 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Jennifer R. Snaith, Deborah J. Holmes-Walker, Jerry R. GreenfieldIndividuals with type 1 diabetes (T1D) frequently fail to achieve glycemic goals and have excess cardiovascular risk and premature death. Adjunctive agents may play a role in reducing morbidity, mortality, and the adverse sequelae of insulin treatment. A surge in type 2 diabetes drug development has revealed agents with benefits beyond glucose lowering, including cardiovascular risk reduction. Could these benefits translate to T1D? Specific trials for T1D ...
Source: Trends in Endocrinology and Metabolism - December 9, 2019 Category: Endocrinology Source Type: research

Impacts of Caffeine during Pregnancy
Publication date: Available online 6 December 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Jingjing Qian, Qi Chen, Sean M. Ward, Enkui Duan, Ying ZhangEpidemiological studies have revealed that caffeine consumption during pregnancy is associated with adverse gestational outcomes, yet the underlying mechanisms remain obscure. Recent animal studies with physiologically relevant dosages have begun to dissect adverse effects of caffeine during pregnancy with respect to oviduct contractility, embryo development, uterine receptivity, and placentation that jointly contribute to pregnancy complications. Interestingly...
Source: Trends in Endocrinology and Metabolism - December 7, 2019 Category: Endocrinology Source Type: research

Coronary Microvascular Dysfunction and Estrogen Receptor Signaling
Publication date: Available online 29 November 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Elif Tunc, Alicia Arredondo Eve, Zeynep Madak-ErdoganChest pain with non-obstructive coronary artery disease (NOCAD) occurs more frequently in women than in men and is mainly related to coronary microvascular disease (CMD). The majority of CMD patients are postmenopausal women, suggesting a role for lack of estrogens in the development and progression of CMD. Patients are often discharged without a clear treatment plan due to the limited understanding of etiology and diagnostic parameters of CMD and have significantly ...
Source: Trends in Endocrinology and Metabolism - November 29, 2019 Category: Endocrinology Source Type: research

A Novel Mechanism for Th17 Inflammation in Human Type 2 Diabetes Mellitus
Publication date: Available online 22 November 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Kaitlin Kiernan, Nancie J. MacIverIn their recent study, Nicholas et al. challenge the current dogma that T cell inflammation must be fueled by glycolysis and demonstrate a novel metabolic mechanism for Th17 inflammation in human type 2 diabetes mellitus (T2DM): a combination of increased environmental long-chain fatty acid metabolites coupled with decreased fatty acid oxidation. (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - November 23, 2019 Category: Endocrinology Source Type: research

Editorial Board and Contents
Publication date: December 2019Source: Trends in Endocrinology & Metabolism, Volume 30, Issue 12Author(s): (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - November 21, 2019 Category: Endocrinology Source Type: research

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Publication date: December 2019Source: Trends in Endocrinology & Metabolism, Volume 30, Issue 12Author(s): (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - November 21, 2019 Category: Endocrinology Source Type: research