A Novel Mechanism for Th17 Inflammation in Human Type 2 Diabetes Mellitus

Publication date: Available online 22 November 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Kaitlin Kiernan, Nancie J. MacIverIn their recent study, Nicholas et al. challenge the current dogma that T cell inflammation must be fueled by glycolysis and demonstrate a novel metabolic mechanism for Th17 inflammation in human type 2 diabetes mellitus (T2DM): a combination of increased environmental long-chain fatty acid metabolites coupled with decreased fatty acid oxidation.
Source: Trends in Endocrinology and Metabolism - Category: Endocrinology Source Type: research