Trends in Endocrinology and Metabolism This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Adult Cardiomyocyte Cell Cycle Detour: Off-ramp to Quiescent Destinations
Publication date: Available online 28 June 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Kathleen M. Broughton, Mark A. SussmanAbility to promote completion of mitotic cycling of adult mammalian cardiomyocytes remains an intractable and vexing challenge, despite being one of the most sought after ‘holy grails’ of cardiovascular research. While some of the struggle is attributable to adult cardiomyocytes themselves that are notoriously post-mitotic, another contributory factor rests with difficulty in definitive tracking of adult cardiomyocyte cell cycle and lack of rigorous measures to track proliferation ...
Source: Trends in Endocrinology and Metabolism - June 29, 2019 Category: Endocrinology Source Type: research

Microbiota and Thyroid Interaction in Health and Disease
Publication date: Available online 27 June 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Eleonore Fröhlich, Richard WahlThe microbiota has been identified as an important factor in health and in a variety of diseases. An altered microbiota composition increases the prevalence of Hashimoto’s thyroiditis (HT) and Graves’ disease (GD). Microbes influence thyroid hormone levels by regulating iodine uptake, degradation, and enterohepatic cycling. In addition, there is a pronounced influence of minerals on interactions between host and microbiota, particularly selenium, iron, and zinc. In manifest thyroid disor...
Source: Trends in Endocrinology and Metabolism - June 29, 2019 Category: Endocrinology Source Type: research

Reactive Carbonyl Species: Diabetic Complication in the Heart and Lungs
Publication date: Available online 25 June 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Cheng-ju Tian, Zhong ZhenAbnormal chemical reactions in hyperglycemia alter normal metabolic processes in diabetes, which is a key process in the production of reactive carbonyls species (RCS). Increasing the concentration of RCS may result in carbonyl/oxidative stress in both the diabetic heart and lung. Ryanodine receptors (RyRs) not only play a key role in heart contraction, including rhythmic contraction and relaxation of the heart, but they are also important for controlling the airway smooth muscle. RCS modifies RyRs...
Source: Trends in Endocrinology and Metabolism - June 26, 2019 Category: Endocrinology Source Type: research

Going Back to the Biology of FGF21: New Insights
Publication date: Available online 24 June 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Jo E. Lewis, Francis J.P. Ebling, Ricardo J. Samms, Kostas TsintzasFibroblast growth factor 21 (FGF21) is a protein highly synthesized in the liver that exerts paracrine and endocrine control of many aspects of energy homeostasis in multiple tissues. In preclinical models of obesity and type 2 diabetes, treatment with FGF21 improves glucose homeostasis and promotes weight loss, and, as a result, FGF21 has attracted considerable attention as a therapeutic agent for the treatment of metabolic syndrome in humans. An improved ...
Source: Trends in Endocrinology and Metabolism - June 25, 2019 Category: Endocrinology Source Type: research

Editorial Board and Contents
Publication date: July 2019Source: Trends in Endocrinology & Metabolism, Volume 30, Issue 7Author(s): (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - June 18, 2019 Category: Endocrinology Source Type: research

Hexokinase-2 Glycolytic Overload in Diabetes and Ischemia–Reperfusion Injury
Publication date: July 2019Source: Trends in Endocrinology & Metabolism, Volume 30, Issue 7Author(s): Naila Rabbani, Paul J. ThornalleyHexokinase-2 (HK2) was recently found to produce increased metabolic flux through glycolysis in hyperglycemia without concurrent transcriptional or other functional regulation. Rather, stabilization to proteolysis by increased glucose substrate binding produced unscheduled increased glucose metabolism in response to high cytosolic glucose concentration. This produces abnormal increases in glycolytic intermediates or glycolytic overload, driving cell dysfunction and vulnerability to the dama...
Source: Trends in Endocrinology and Metabolism - June 18, 2019 Category: Endocrinology Source Type: research

Subscription and Copyright Information
Publication date: July 2019Source: Trends in Endocrinology & Metabolism, Volume 30, Issue 7Author(s): (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - June 18, 2019 Category: Endocrinology Source Type: research

Gluconeogenic Enzymes in β-Cells: Pharmacological Targets for Improving Insulin Secretion
Publication date: Available online 15 June 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Francisco Westermeier, Todd Holyoak, Joel L. Asenjo, Rodrigo Gatica, Francisco Nualart, Ian Burbulis, Romina BertinatPancreatic β-cells express the gluconeogenic enzymes glucose 6-phosphatase (G6Pase), fructose 1,6-bisphosphatase (FBP), and phosphoenolpyruvate (PEP) carboxykinase (PCK), which modulate glucose-stimulated insulin secretion (GSIS) through their ability to reverse otherwise irreversible glycolytic steps. Here, we review current knowledge about the expression and regulation of these enzymes in the context of m...
Source: Trends in Endocrinology and Metabolism - June 17, 2019 Category: Endocrinology Source Type: research

Platelets as Potent Signaling Entities in Type 2 Diabetes Mellitus
Publication date: Available online 10 June 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Etheresia PretoriusType 2 diabetes mellitus (T2DM) is a multifactorial disease with a dysregulated circulating inflammatory molecule tendency. T2DM is closely associated with systemic inflammation, endothelial dysfunction, cardiovascular risk, and increased clotting susceptibility. Platelets have fundamental roles in the development and propagation of inflammation and cardiovascular risk. They signal through membrane receptors, resulting in (hyper)activation and release of inflammatory molecules from platelet compartments....
Source: Trends in Endocrinology and Metabolism - June 11, 2019 Category: Endocrinology Source Type: research

Nitro-Fatty Acid Logistics: Formation, Biodistribution, Signaling, and Pharmacology
Publication date: Available online 10 June 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Francisco J. Schopfer, Nicholas K.H. KhooIn addition to supporting cellular energetic demands and providing building blocks for lipid synthesis, fatty acids (FAs) are precursors of potent signaling molecules. In particular, the presence of conjugated double bonds on the fatty-acyl chain provides a preferential target for nitration generating nitro-FAs (NO2-FAs). The formation of NO2-FAs is a nonenzymatic process that requires reactive nitrogen species and occurs locally at the site of inflammation or during gastric acidifi...
Source: Trends in Endocrinology and Metabolism - June 11, 2019 Category: Endocrinology Source Type: research

Anti-Müllerian Hormone in PCOS: A Review Informing International Guidelines
Publication date: Available online 31 May 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Helena Teede, Marie Misso, Eliza C. Tassone, Didier Dewailly, Ernest Hy Ng, Ricardo Azziz, Robert J. Norman, Marianne Andersen, Stephen Franks, Kathleen Hoeger, Samantha Hutchison, Sharon Oberfield, Duru Shah, Femke Hohmann, Sasha Ottey, Preeti Dabadghao, Joop S.E. LavenPolycystic ovary syndrome (PCOS) affects 8–13% of women. The Rotterdam diagnostic criteria include polycystic ovarian morphology (PCOM) on ultrasound, but given recognized challenges, serum anti-Müllerian hormone (AMH) is proposed as an alternative. To in...
Source: Trends in Endocrinology and Metabolism - June 1, 2019 Category: Endocrinology Source Type: research

Circadian Clocks and Cancer: Timekeeping Governs Cellular Metabolism
Publication date: Available online 30 May 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Amandine Verlande, Selma MasriThe circadian clock is a biological mechanism that dictates an array of rhythmic physiological processes. Virtually all cells contain a functional clock whose disruption results in altered timekeeping and detrimental systemic effects, including cancer. Recent advances have connected genetic disruption of the clock with multiple transcriptional and signaling networks controlling tumor initiation and progression. An additional feature of this circadian control relies on cellular metabolism, both ...
Source: Trends in Endocrinology and Metabolism - May 31, 2019 Category: Endocrinology Source Type: research

Adipose Progenitor Cells Contribute to Lipid Spillover during Obesity
Publication date: Available online 29 May 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Nabil Rabhi, Stephen R. FarmerA recent study (Girousse et al. Cell Rep. 2019;27:323–333) shows that CXCR4+ adipose progenitors (APCs) contribute to lipid spillover during high-fat feeding through their release from subcutaneous fat depots (ScATs) and migration to skeletal muscle where they differentiate into adipocytes. Pharmacological antagonism of CXCR4, which prevents the CXCL12-dependent retention of APCs in ScAT, mimics the effects of overfeeding. (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - May 30, 2019 Category: Endocrinology Source Type: research

Editorial Board and Contents
Publication date: June 2019Source: Trends in Endocrinology & Metabolism, Volume 30, Issue 6Author(s): (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - May 30, 2019 Category: Endocrinology Source Type: research

Subscription and Copyright Information
Publication date: June 2019Source: Trends in Endocrinology & Metabolism, Volume 30, Issue 6Author(s): (Source: Trends in Endocrinology and Metabolism)
Source: Trends in Endocrinology and Metabolism - May 30, 2019 Category: Endocrinology Source Type: research