Anti-Müllerian Hormone in PCOS: A Review Informing International Guidelines

Publication date: Available online 31 May 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Helena Teede, Marie Misso, Eliza C. Tassone, Didier Dewailly, Ernest Hy Ng, Ricardo Azziz, Robert J. Norman, Marianne Andersen, Stephen Franks, Kathleen Hoeger, Samantha Hutchison, Sharon Oberfield, Duru Shah, Femke Hohmann, Sasha Ottey, Preeti Dabadghao, Joop S.E. LavenPolycystic ovary syndrome (PCOS) affects 8–13% of women. The Rotterdam diagnostic criteria include polycystic ovarian morphology (PCOM) on ultrasound, but given recognized challenges, serum anti-Müllerian hormone (AMH) is proposed as an alternative. To inform international PCOS guidelines, a systematic review was completed. Key identified gaps include large international studies in well-defined populations across the lifespan, clustering of AMH with PCOS features, relationships to long-term health outcomes, and improved quality, assay standardization, and sample handling, all needed to determine cut offs. Here we identify research priorities to address these gaps and enhance AMH utility in PCOS. Once issues are addressed, AMH levels could replace more costly and less accessible ultrasound in PCOS diagnosis.
Source: Trends in Endocrinology and Metabolism - Category: Endocrinology Source Type: research