ER Stress Priming of Mitochondrial Respiratory suPERKomplex Assembly

Publication date: Available online 24 August 2019Source: Trends in Endocrinology & MetabolismAuthor(s): Ruben Quintana-Cabrera, Maria Eugenia SorianoAssembly factors are necessary for the formation of mitochondrial supercomplexes (SCs) and in making cellular respiration more efficient. In a recent study, Balsa et al. (Mol. Cell, 2019) report that nutrient-induced endoplasmic reticulum (ER) stress engages PERK–eIF2α-mediated transcription of the SCs assembly factor SCAF1, events that coordinate ER stress and SCs formation to improve bioenergetics.
Source: Trends in Endocrinology and Metabolism - Category: Endocrinology Source Type: research