Cognitive and psychopathology correlates of brain white/grey matter structure in severely psychotic schizophrenic inpatients
Publication date: June 2018 Source:Schizophrenia Research: Cognition, Volume 12 Author(s): Nerisa Banaj, Federica Piras, Fabrizio Piras, Valentina Ciullo, Mariangela Iorio, Claudia Battaglia, Donatella Pantoli, Giuseppe Ducci, Gianfranco Spalletta The brain structural correlates of cognitive and psychopathological symptoms within the active phase in severely psychotic schizophrenic inpatients have been rarely investigated. Twenty-eight inpatients with a DSM-5 diagnosis of Schizophrenia (SZ), admitted for acute psychotic decompensation, were assessed through a comprehensive neuropsychological and psychopathologic...
Source: Schizophrenia Research: Cognition - February 22, 2018 Category: Psychiatry Source Type: research
Effects of transcranial direct current stimulation on working memory and negative symptoms in schizophrenia: a phase II randomized sham-controlled trial
Conclusion The results from this trial highlight the therapeutic effects of tDCS for treatment of persistent symptoms in schizophrenia, with reduction of negative symptoms. We were not able to confirm the superiority of active tDCS over sham to improve working memory performance. Larger sample size studies are needed to confirm these findings. (Source: Schizophrenia Research: Cognition)
Source: Schizophrenia Research: Cognition - February 21, 2018 Category: Psychiatry Source Type: research
Polygenic signal for symptom dimensions and cognitive performance in patients with chronic schizophrenia
Publication date: June 2018 Source:Schizophrenia Research: Cognition, Volume 12 Author(s): Rose Mary Xavier, Jennifer R. Dungan, Richard S.E. Keefe, Allison Vorderstrasse Genetic etiology of psychopathology symptoms and cognitive performance in schizophrenia is supported by candidate gene and polygenic risk score (PRS) association studies. Such associations are reported to be dependent on several factors - sample characteristics, illness phase, illness severity etc. We aimed to examine if schizophrenia PRS predicted psychopathology symptoms and cognitive performance in patients with chronic schizophrenia. We also exa...
Source: Schizophrenia Research: Cognition - January 29, 2018 Category: Psychiatry Source Type: research
Galantamine-memantine combination effective in dementia: Translate to dementia praecox?
Publication date: June 2018 Source:Schizophrenia Research: Cognition, Volume 12 Author(s): Maju Mathew Koola, Ajay K. Parsaik (Source: Schizophrenia Research: Cognition)
Source: Schizophrenia Research: Cognition - January 29, 2018 Category: Psychiatry Source Type: research
Diminished Hedonic response in neuroleptic-free youth at ultra high-risk for psychosis
In this study, we examined neurophysiological and self-reported response to emotional stimuli in UHR (n =23) and healthy control (CN: n =30) participants who passively viewed pleasant, unpleasant, and neutral images for 500ms while the electroencephalogram was recorded and then provided self-reports of valence and arousal to the stimuli. The Late Positive Potential (LPP) event related potential (ERP) component was used as a neurophysiological marker of emotional reactivity. Results indicated that CN participants had higher LPP amplitude for pleasant and unpleasant compared to neutral stimuli; however, UHR youth displayed n...
Source: Schizophrenia Research: Cognition - December 24, 2017 Category: Psychiatry Source Type: research
The influence of schizotypal traits on attention under high perceptual load
This article considers whether perceptual resource limitations play a role in moderating attentional abnormalities in SSD. According to perceptual load theory, perceptual resource limitations can lead to attenuated or superior performance on dual-task paradigms depending on whether participants are required to process, or attempt to ignore, secondary stimuli. If SSD is associated with perceptual resource limitations, and if it represents the extreme end of an otherwise normally distributed neuropsychological phenotype, schizotypal traits in the general population should lead to disproportionate performance costs on dual-ta...
Source: Schizophrenia Research: Cognition - November 9, 2017 Category: Psychiatry Source Type: research
Model selection and prediction of outcomes in recent onset schizophrenia patients who undergo cognitive training
Publication date: March 2018 Source:Schizophrenia Research: Cognition, Volume 11 Author(s): Ian S. Ramsay, Sisi Ma, Melissa Fisher, Rachel L. Loewy, J. Daniel Ragland, Tara Niendam, Cameron S. Carter, Sophia Vinogradov Predicting treatment outcomes in psychiatric populations remains a challenge, but is increasingly important in the pursuit of personalized medicine. Patients with schizophrenia have deficits in cognition, and targeted cognitive training (TCT) of auditory processing and working memory has been shown to improve some of these impairments; but little is known about the baseline patient characteristics ...
Source: Schizophrenia Research: Cognition - November 9, 2017 Category: Psychiatry Source Type: research
Using virtual reality to assess theory of mind subprocesses and error types in early and chronic schizophrenia
This study examined the nature and types of ToM impairment in individuals with early (n =26) and chronic schizophrenia (n =32) using a novel virtual reality task. Clinical participants and demographically-matched controls were administered the Virtual Assessment of Mentalising Ability, which provides indices of first- and second-order cognitive and affective ToM, and quantifies three different types of mentalising errors (viz., overmentalising, reduced mentalising, and no ToM). Individuals with early schizophrenia performed significantly poorer than healthy controls on first-order affective and second-order cognitive and a...
Source: Schizophrenia Research: Cognition - September 28, 2017 Category: Psychiatry Source Type: research
Feasibility and preliminary efficacy of remotely delivering cognitive training to people with schizophrenia using tablets
Conclusion Although underpowered and not randomized, this study demonstrates that delivering CT remotely to people with SZ using tablets is feasible and results in retention rates, adherence, and cognitive and functional outcome improvements that are comparable to those observed when CT is delivered in the laboratory. This has important implications in terms of scalability and dissemination of CT. These results require confirmation in larger samples. (Source: Schizophrenia Research: Cognition)
Source: Schizophrenia Research: Cognition - August 4, 2017 Category: Psychiatry Source Type: research
Speed and capacity of working memory and executive function in schizophrenia compared to unipolar depression
Publication date: December 2017 Source:Schizophrenia Research: Cognition, Volume 10 Author(s): Wolfgang Trapp, Simone Dotterweich, Lena Hintner, Hannah Wollny, Stefan Lautenbacher, Göran Hajak Schizophrenia is associated with deficits in working memory (WM) and executive functioning (EF) that are present from prodrome to chronic stages of the disease and are related to social and occupational functioning. Recent empirical findings suggest that schizophrenia patients might suffer from a specific speed deficit regarding WM operations that also affects EF. To test this hypothesis, executive functioning (EF) and worki...
Source: Schizophrenia Research: Cognition - July 29, 2017 Category: Psychiatry Source Type: research
Is the association between offspring intelligence and parents' educational attainment influenced by schizophrenia or mood disorder in parents?
In conclusion, findings from this study show a more positive effect of education on offspring intelligence in mothers with schizophrenia compared to mothers from the control group. This effect could have both environmental and genetic explanations. (Source: Schizophrenia Research: Cognition)
Source: Schizophrenia Research: Cognition - July 27, 2017 Category: Psychiatry Source Type: research
No association between symptom severity and MMN impairment in schizophrenia: A meta-analytic approach
Publication date: September 2017 Source:Schizophrenia Research: Cognition, Volume 9 Author(s): Molly A. Erickson, Matthew Albrecht, Abigail Ruffle, Leah Fleming, Philip Corlett, James Gold The mismatch negativity (MMN) is an event-related potential that is consistently attenuated in people with schizophrenia. Within the predictive coding model of psychosis, MMN impairment is thought to reflect the same prediction failures that are also thought to underlie the development and crystallization of delusions and hallucinations. However, the true relationship between symptom severity and MMN impairment across studies has...
Source: Schizophrenia Research: Cognition - May 18, 2017 Category: Psychiatry Source Type: research
Omega-3 fatty acids related to cognitive impairment in patients with schizophrenia
Publication date: September 2017 Source:Schizophrenia Research: Cognition, Volume 9 Author(s): Kazumi Satogami, Shun Takahashi, Shinichi Yamada, Satoshi Ukai, Kazuhiro Shinosaki Cognitive impairment is strongly associated with functional outcome in patients with schizophrenia but its pathophysiology remains largely unclear. Involvement of omega-3 fatty acids in the cognitive function of healthy individuals and patients with neuropsychiatric disease has received increasing attention. The aim of this study was to examine the relationship between omega-3 fatty acids with cognitive function, social function, and psychia...
Source: Schizophrenia Research: Cognition - May 18, 2017 Category: Psychiatry Source Type: research
Self versus informant reports on the specific levels of functioning scale: Relationships to depression and cognition in schizophrenia and schizoaffective disorder
We examined discrepancies between self and informant reports of function on the Specific levels of function scale as a metric of insight for interpersonal, social acceptance, work and activities. We examined two samples of individuals with schizophrenia and/or schizoaffective disorder (Ns of 188 and 67 respectively). In Sample 1, cognition was measured using the Dot Probe Expectancy Task. In Sample 2, cognition was measured by averaging several subtests from the MATRICS consensus cognitive battery, as well as additional measures of working memory. In both samples, depression was measured using the Brief Psychiatric Rating ...
Source: Schizophrenia Research: Cognition - May 9, 2017 Category: Psychiatry Source Type: research
EPICOG-SCH: A brief battery to screen cognitive impact of schizophrenia in stable outpatients
Publication date: June 2017 Source:Schizophrenia Research: Cognition, Volume 8 Author(s): Silvia Zaragoza Domingo, Julio Bobes, Maria-Paz García-Portilla, Claudia Morralla Brief batteries in schizophrenia, are needed to screen for the cognitive impact of schizophrenia. We aimed to validate and co-norm the Epidemiological Study of Cognitive Impairment in Schizophrenia (EPICOG-SCH) derived brief cognitive battery. A cross-sectional outpatient evaluation was conducted of six-hundred-seventy-two patients recruited from 234 centers. The brief battery included well-known subtests available worldwide that cover cognitive d...
Source: Schizophrenia Research: Cognition - March 18, 2017 Category: Psychiatry Source Type: research
