Effects of transcranial direct current stimulation on working memory and negative symptoms in schizophrenia: a phase II randomized sham-controlled trial
ConclusionThe results from this trial highlight the therapeutic effects of tDCS for treatment of persistent symptoms in schizophrenia, with reduction of negative symptoms. We were not able to confirm the superiority of active tDCS over sham to improve working memory performance. Larger sample size studies are needed to confirm these findings. (Source: Schizophrenia Research: Cognition)
Source: Schizophrenia Research: Cognition - July 10, 2018 Category: Psychiatry Source Type: research
Cognitive and psychopathology correlates of brain white/grey matter structure in severely psychotic schizophrenic inpatients
Publication date: June 2018Source: Schizophrenia Research: Cognition, Volume 12Author(s): Nerisa Banaj, Federica Piras, Fabrizio Piras, Valentina Ciullo, Mariangela Iorio, Claudia Battaglia, Donatella Pantoli, Giuseppe Ducci, Gianfranco SpallettaAbstractThe brain structural correlates of cognitive and psychopathological symptoms within the active phase in severely psychotic schizophrenic inpatients have been rarely investigated. Twenty-eight inpatients with a DSM-5 diagnosis of Schizophrenia (SZ), admitted for acute psychotic decompensation, were assessed through a comprehensive neuropsychological and psychopathological ba...
Source: Schizophrenia Research: Cognition - July 10, 2018 Category: Psychiatry Source Type: research
Speech-on-speech masking and psychotic symptoms in schizophrenia
This study investigated whether the TSR impairment in schizophrenia is associated with their impaired auditory working memory or certain psychotic symptoms. Thirty participants with schizophrenia (mean age = 35.2 ± 12.7 years) and 30 demographics-matched healthy controls (mean age = 32.9 ± 10.9 years) were tested for their TSR against a two-talker-speech masker. Auditory working memory and memory capacity were evaluated using the Paced Auditory Serial Addition Test (PASAT) and Digit Span Test. Psychotic symptoms were evaluated using the Positive and Negative Syndrome Scale (PANSS). The results showed ...
Source: Schizophrenia Research: Cognition - July 10, 2018 Category: Psychiatry Source Type: research
Long-term treatment with clozapine and verbal memory performance in schizophrenia
Publication date: June 2018Source: Schizophrenia Research: Cognition, Volume 12Author(s): Letícia S. Czepielewski, Marina D.B. Londero, Mathias H. de Sousa, Carolina P. Perin, Helena C. Maldonado, Felipe C.A. Claudino, Clarissa S. GamaAbstractClozapine is more efficacious than first-generation antipsychotics for positive and negative symptoms, although it is related with serious adverse effects. Because of this profile, it could also have an impact on cognition. Therefore, we evaluated learning ability of 31 treatment-resistant individuals with SZ using clozapine uninterruptedly for 18.23 ± 4.71 years and 26 non-tr...
Source: Schizophrenia Research: Cognition - July 10, 2018 Category: Psychiatry Source Type: research
Predictive timing disturbance is a precise marker of schizophrenia
Publication date: June 2018Source: Schizophrenia Research: Cognition, Volume 12Author(s): Valentina Ciullo, Federica Piras, Daniela Vecchio, Nerisa Banaj, Jennifer T. Coull, Gianfranco SpallettaAbstractTiming disturbances have being proposed as a key component of schizophrenia pathogenesis. However, the contribution of cognitive impairment to such disorders has not been clarified. Here, we investigated duration estimation and predictive timing in 30 patients with DSM-5 diagnosis of schizophrenia (SZ) compared to 30 healthy controls (HC). Duration estimation was examined in a temporal and colour discrimination task, fully c...
Source: Schizophrenia Research: Cognition - July 10, 2018 Category: Psychiatry Source Type: research
Effect of cognitive function on jumping to conclusion in patients with schizophrenia
Publication date: June 2018Source: Schizophrenia Research: Cognition, Volume 12Author(s): Tomoya Takeda, Masahito Nakataki, Masashi Ohta, Sayo Hamatani, Kanae Matsuura, Tetsuro OhmoriAbstractThe “jumping to conclusion” (JTC) bias is related to the formation and maintenance of delusions. Higher JTC bias can be based on both neurocognitive dysfunction and social cognitive dysfunction in patients with schizophrenia. The aim of this study was to assess the relationship between JTC bias, neurocognition, and social cognition in patients with schizophrenia.A total of 22 patients with schizophrenia and 21 controls participated...
Source: Schizophrenia Research: Cognition - July 10, 2018 Category: Psychiatry Source Type: research
The relationship between clinical insight and cognitive and affective empathy in schizophrenia
ConclusionFindings suggest that affective empathy is relatively intact across phases of illness whereas cognitive empathy abilities are compromised and could be targets for psychotherapy intervention. (Source: Schizophrenia Research: Cognition)
Source: Schizophrenia Research: Cognition - July 10, 2018 Category: Psychiatry Source Type: research
The impact of reward on attention in schizophrenia
Publication date: June 2018Source: Schizophrenia Research: Cognition, Volume 12Author(s): Sonia Bansal, Benjamin M. Robinson, Joy J. Geng, Carly J. Leonard, Britta Hahn, Steven J. Luck, James M. GoldAbstractTraditionally, attention was thought to be directed by either top-down goals or bottom-up salience. Recent studies have shown that the reward history of a stimulus feature also acts as a powerful attentional cue. This is particularly relevant in schizophrenia, which is characterized by motivational and attentional deficits. Here, we examine the impact of reward on selective attention.Forty-eight people with schizophreni...
Source: Schizophrenia Research: Cognition - July 10, 2018 Category: Psychiatry Source Type: research
Increased social cognitive bias in subclinical paranoia
Publication date: June 2018Source: Schizophrenia Research: Cognition, Volume 12Author(s): Hans S. Klein, Skylar Kelsven, Amy E. Pinkham (Source: Schizophrenia Research: Cognition)
Source: Schizophrenia Research: Cognition - July 10, 2018 Category: Psychiatry Source Type: research
Model selection and prediction of outcomes in recent onset schizophrenia patients who undergo cognitive training
Publication date: March 2018Source: Schizophrenia Research: Cognition, Volume 11Author(s): Ian S. Ramsay, Sisi Ma, Melissa Fisher, Rachel L. Loewy, J. Daniel Ragland, Tara Niendam, Cameron S. Carter, Sophia VinogradovAbstractPredicting treatment outcomes in psychiatric populations remains a challenge, but is increasingly important in the pursuit of personalized medicine. Patients with schizophrenia have deficits in cognition, and targeted cognitive training (TCT) of auditory processing and working memory has been shown to improve some of these impairments; but little is known about the baseline patient characteristics pred...
Source: Schizophrenia Research: Cognition - July 5, 2018 Category: Psychiatry Source Type: research
The influence of schizotypal traits on attention under high perceptual load
This article considers whether perceptual resource limitations play a role in moderating attentional abnormalities in SSD. According to perceptual load theory, perceptual resource limitations can lead to attenuated or superior performance on dual-task paradigms depending on whether participants are required to process, or attempt to ignore, secondary stimuli. If SSD is associated with perceptual resource limitations, and if it represents the extreme end of an otherwise normally distributed neuropsychological phenotype, schizotypal traits in the general population should lead to disproportionate performance costs on dual-ta...
Source: Schizophrenia Research: Cognition - July 5, 2018 Category: Psychiatry Source Type: research
Diminished Hedonic response in neuroleptic-free youth at ultra high-risk for psychosis
In this study, we examined neurophysiological and self-reported response to emotional stimuli in UHR (n = 23) and healthy control (CN: n = 30) participants who passively viewed pleasant, unpleasant, and neutral images for 500 ms while the electroencephalogram was recorded and then provided self-reports of valence and arousal to the stimuli. The Late Positive Potential (LPP) event related potential (ERP) component was used as a neurophysiological marker of emotional reactivity. Results indicated that CN participants had higher LPP amplitude for pleasant and unpleasant compared to neutral stimuli; ho...
Source: Schizophrenia Research: Cognition - July 5, 2018 Category: Psychiatry Source Type: research
Galantamine-memantine combination effective in dementia: Translate to dementia praecox?
Publication date: June 2018Source: Schizophrenia Research: Cognition, Volume 12Author(s): Maju Mathew Koola, Ajay K. Parsaik (Source: Schizophrenia Research: Cognition)
Source: Schizophrenia Research: Cognition - July 5, 2018 Category: Psychiatry Source Type: research
Polygenic signal for symptom dimensions and cognitive performance in patients with chronic schizophrenia
Publication date: June 2018Source: Schizophrenia Research: Cognition, Volume 12Author(s): Rose Mary Xavier, Jennifer R. Dungan, Richard S.E. Keefe, Allison VorderstrasseAbstractGenetic etiology of psychopathology symptoms and cognitive performance in schizophrenia is supported by candidate gene and polygenic risk score (PRS) association studies. Such associations are reported to be dependent on several factors - sample characteristics, illness phase, illness severity etc. We aimed to examine if schizophrenia PRS predicted psychopathology symptoms and cognitive performance in patients with chronic schizophrenia. We also exa...
Source: Schizophrenia Research: Cognition - July 5, 2018 Category: Psychiatry Source Type: research
Effects of transcranial direct current stimulation on working memory and negative symptoms in schizophrenia: a phase II randomized sham-controlled trial
ConclusionThe results from this trial highlight the therapeutic effects of tDCS for treatment of persistent symptoms in schizophrenia, with reduction of negative symptoms. We were not able to confirm the superiority of active tDCS over sham to improve working memory performance. Larger sample size studies are needed to confirm these findings. (Source: Schizophrenia Research: Cognition)
Source: Schizophrenia Research: Cognition - July 5, 2018 Category: Psychiatry Source Type: research
