Revista Brasileira de Farmacognosia 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Thermal and chemical characterization of Dicksonia sellowiana extract by means of thermal analysis
Abstract Dicksonia sellowiana Hook., Dicksoniaceae, is a tree-fern which is being recently used in medicine mainly for its phytotherapic activities. While several other studies have focused on D. sellowiana extract characterization in terms of its biological and antioxidant activity, the novelty of this work aims to understand the fate of this extract during thermal disposal through thermogravimetry/differential thermal analysis, thermogravimetry/mass spectrometry, Fourier transform infrared spectroscopy and elemental analysis, to further characterize this plant's extract. Thermal analysis revealed mass loss within three w...
Source: Revista Brasileira de Farmacognosia - October 11, 2018 Category: Drugs & Pharmacology Source Type: research
Nanosuspension of quercetin: preparation, characterization and effects against Aedes aegypti larvae
Abstract Aedes aegypti (Diptera: Culicidae) is the main vector of some neglected diseases, including dengue. It is very important to develop formulations that increase effectiveness of vector control with low toxicity. Quercetin is a plant-derived flavonoid that modulates the development of some insects. The low water solubility of quercetin impairs the development of water-dispersible commercial products. To circumvent this problem, the preparation of nanoformulations is considered promising. Thus, this study aimed to evaluate the effect of bulk and quercetin nanosuspension against A. aegypti larvae and also to investigat...
Source: Revista Brasileira de Farmacognosia - October 11, 2018 Category: Drugs & Pharmacology Source Type: research
Optimization of flavonoid extraction from Passiflora quadrangularis leaves with sedative activity and evaluation of its stability under stress conditions
Abstract Passiflora species have been widely used in folk medicine as tranquilizers, and previous pharmacological studies have reported sedative activity for P. quadrangularis L., Passifloraceae, leaf extracts. The aim of this work was to contribute to the standardization of P. quadrangularis leaf extract with sedative activity. For this purpose, the extraction of total flavonoids was optimized, evaluating variables such as drug-solvent ratio, extraction solvents and extraction time, using Response Surface Methodology. The stability of total and individual flavonoids on the optimized extract of P. quadrangularis leaves und...
Source: Revista Brasileira de Farmacognosia - October 11, 2018 Category: Drugs & Pharmacology Source Type: research
Antitumor activity and toxicity of volatile oil from the leaves of Annona leptopetala
Abstract Annona leptopetala (R.E.Fr.) H. Rainer, Annonaceae, is used in folk medicine like antitumor and anti-inflammatory. The aim of this study was to determine chemical composition, toxicity and antitumor activity of A. leptopetala leaves volatile oil. Fresh leaves were hydrodistilled and then the volatile oil chemical composition was assessed by gas chromatography and mass spectrometry. Toxicity was assessed using haemolysis, micronucleus and acute toxicity protocols. Antitumor effects were determined in vitro and in vivo, using sulforhodamine B assay and sarcoma 180 murine tumor model, respectively. Spathulenol was th...
Source: Revista Brasileira de Farmacognosia - October 11, 2018 Category: Drugs & Pharmacology Source Type: research
Phenolic-antioxidant capacity of mango seed kernels: therapeutic effect against viper venoms
In this study, mango seed kernels extract contained a considerable amount of phenolics and flavonoids (17,400 and 3325 mg/100 g seed, respectively). The HPLC profiling revealed that hesperidin was the major phenolic compound of the mango seed kernels extract. This is the first report find hesperidin in mango extracts. The phenolic compounds of mango seed kernels extract were effective in scavenging free radicals of DPPH and ABTS with IC50 values of 47.3 and 7.9 µg/ml, respectively. The total antioxidant activity of mango seed kernels extract based on the reduction of molybdenum was also measured. The phenolic compounds of...
Source: Revista Brasileira de Farmacognosia - October 11, 2018 Category: Drugs & Pharmacology Source Type: research
Hydroethanolic extract of Tropaeolum majus promotes anxiolytic effects on rats
This study investigated the central pharmacological actions of the prolonged treatment with a hydroethanolic extract of T. majus in male Wistar rats in the elevated plus maze and hole-board behavioral models. For this, rats were daily treated with distillated water (negative control); diazepam (1 mg/kg) or hydroethanolic extract of T. majus (75, 150 and 300 mg/kg), for 29 days (by gavage) and were submitted to elevated plus maze and hole-board. Animals treated with all hydroethanolic extract of T. majus or diazepam doses increased the percentage of entries in open arms when compared to control group. However, only treatmen...
Source: Revista Brasileira de Farmacognosia - October 11, 2018 Category: Drugs & Pharmacology Source Type: research
LC–MS/MS determination of deoxyelephantopin, a novel anti-tumor candidate in rat plasma and its application to a pharmacokinetic study in rats
Abstract A specific, sensitive and robust LC – MS/MS method was developed and validated for the quantification of deoxyelephantopin in rat plasma using simvastatin as an internal standard as per regulatory guidelines of Bioanalytical Method Validation. Plasma sample was prepared through liquid-liquid extraction. Chromatographic separation was performed on an Agela-C18 analytical column (1.8 µm, 2.1 mm × 50 mm) with an isocratic mobile phase consisting of 0.05% formic acid (dissolved in acetonitrile) and water (55:45, v/v) at a flow rate of 0.5 ml/min. The column oven was maintained at 40 ºC and the injection volume wa...
Source: Revista Brasileira de Farmacognosia - October 11, 2018 Category: Drugs & Pharmacology Source Type: research
Pharmacological and chemical properties of some marine echinoderms
Abstract Echinoderms have attracted the attention of scientists over the past few years after identifying a variety of unique structures endowed by interesting biological properties. However, the Moroccan coast biodiversity is still uninvestigated. In our ongoing attempts to valorize the rich Moroccan marine environment, this study aimed at assessing the antimicrobial activity of extracts obtained from three echinoderms Astropecten irregularis, Luidia sarsi and Ophiura albida against the human pathogens: Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Salmonella enterica and Bacillus subtilis. Moreover, th...
Source: Revista Brasileira de Farmacognosia - October 11, 2018 Category: Drugs & Pharmacology Source Type: research
Acetylcholinesterase inhibitory activity of a neurosteroidal alkaloid from the upside-down jellyfish Cassiopea andromeda venom
In conclusion, the isolated neurosteroidal alkaloid from Cassiopea andromeda was a potent antiAChE agent with strong binding to both the catalytic and peripheral sites of acetylcholinesterase that correlated well with the experimental data. Further s tudies are required to determine whether androtoxin B could be a potential treatment for Alzheimer's disease. (Source: Revista Brasileira de Farmacognosia)
Source: Revista Brasileira de Farmacognosia - October 11, 2018 Category: Drugs & Pharmacology Source Type: research
Salvastearolide, a new acyl-glyceride, and other constituents from the seeds of Salvadora persica
Abstract The chemical investigation of the n-hexane fraction of Salvadora persica L., Salvadoraceae, seeds afforded a new stearic acid ester, salvastearolide, together with five other phytosteroids identified as stigmasterol, β -sitosterol, Δ 7-campesterol, Δ 7-avenasterol and campesterol. Their structures were established on the basis of extensive spectroscopic methods including 1D and 2D NMR experiments and HRESI mass spectrometry. In addition, salvastearolide and the isolated fractions were tested for their cytotoxicity against human cancer cell lines MCF-7, MDA-MB-231 and HT-29. The n-hexane fraction exhibited signi...
Source: Revista Brasileira de Farmacognosia - October 11, 2018 Category: Drugs & Pharmacology Source Type: research
Carnosol from Lepechinia mutica and tiliroside from Vallea stipularis: Two promising inhibitors of BuChE
Abstract Lepechinia mutica (Benth.) Epling, Lamiaceae, and Vallea stipularis L.f., Elaeocarpaceae, are the object of the present study. These plants are endemic to the Andean region and have attracted our attention on the basis of interesting results obtained in a preliminary anticholinesterase screening. Actually, carnosol and tiliroside, isolated from L. mutica and V. stipularis, respectively, have shown a promising selective inhibitory activity against butyrylcholinesterase. Specifically, the anti-butyrylcholinesterase activity of carnosol was 5.15 µM and that of tiliroside was 52.9 µM, compared to 8.568 ± 0.570 µM ...
Source: Revista Brasileira de Farmacognosia - October 11, 2018 Category: Drugs & Pharmacology Source Type: research
In vitro antileishmanial and antitrypanosomal activity of compounds isolated from the roots of Zanthoxylum tingoassuiba
Abstract Five coumarins (5,7,8-trimethoxycoumarin (1), sabandin (2), cubreuva lactone (3), 5,7-dimethoxycoumarin (5) and braylin (6)), seven furoquinoline alkaloids (isopimpinelin (4), pteleine (7), maculine (8), skimianine (10), robustine (11), y-fagarine (12) and dictamine (13) and the furofuran type lignin syringaresinol (9)) have been identified for the first time in the roots of Zanthoxylum tingoassuiba A. St.-Hil., Rutaceae. Pure compounds 1, 6, 9, 12 were tested against Leishmania amazonensis parasites and epimastigotes forms of Trypanosoma cruzi. All the tested products displayed an antiparasitic activity similar t...
Source: Revista Brasileira de Farmacognosia - October 11, 2018 Category: Drugs & Pharmacology Source Type: research
Trifolium pratense: Friable calli, cell culture protocol and isoflavones content in wild plants, in vitro and cell cultures analyzed by UPLC
Abstract Trifolium pratense L., Fabaceae, is a rich source of isoflavones and has become the focus of several studies related to its phytoestrogenic activity. The aim of this study was to establish germination and cell cultures protocol for T. pratense and quantify isoflavones content in cell cultures, in vitro cultured and wild plants harvested in two different seasons. Murashige Skoog medium supplemented with naphthalene acetic acid and kinetin was able to produce the highest formation of friable calli. Calli cultures were analyzed qualitatively after 60 days of culture, and in vitro plants after 30, 45 and 60 days of cu...
Source: Revista Brasileira de Farmacognosia - October 11, 2018 Category: Drugs & Pharmacology Source Type: research
Comprehensive chemical analysis of the flower buds of five Lonicera species by ATR-FTIR, HPLC-DAD, and chemometric methods
Abstract Lonicera japonica Thunb., Caprifoliaceae, has been employed in traditional Chinese medicine for thousands of years. However, it is frequently confused with closely related species, and thus, a mixture of these species is commonly used. The sources of Lonicera species must be accurately and rapidly determined to ensure the clinical efficacy of herbal medicines. Attenuated total reflectance Fourier transform infrared spectroscopy and high-performance liquid chromatography with a diode array detector, combined with chemometrics methods, were used to comprehensively evaluate the Lonicera quality. The infrared fingerpr...
Source: Revista Brasileira de Farmacognosia - October 11, 2018 Category: Drugs & Pharmacology Source Type: research
HPLC fingerprint and simultaneous quantitative analysis of phyllanthin and hypophyllanthin for identification and authentication of Phyllanthus niruri from related species
Abstract A precise and accurate method for the identification and authentication of Phyllanthus niruri L. from P. debilis Klein ex Willd. and P. urinaria L., Phyllanthaceae, was developed using high-performance liquid chromatography. Chromatographic fingerprint analysis was combined with simultaneous quantification of phyllanthin and hypophyllanthin for the developed method. Phyllanthin and hypophyllanthin were successfully separated and quantified under this proposed method. The highest amount of phyllanthin and hypophyllanthin was found in P. niruri compared to P. debilis and P. urinaria. Fingerprint chromatogram of the ...
Source: Revista Brasileira de Farmacognosia - October 11, 2018 Category: Drugs & Pharmacology Source Type: research
