Revista Brasileira de Farmacognosia This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The use of different indicators for interpreting the local knowledge loss on medical plants
ABSTRACT The increasing loss of local ecological knowledge may have negative impacts on the resilience of socio-ecological systems and may also negatively impact bioprospecting efforts, since local ecological knowledge is an important source of information for searching new drugs. Recent studies try to evaluate whether communities are experiencing loss of local ecological knowledge. However, some of them make conclusions which are erroneously based on specific analyses of a single indicator. We propose an integrative analysis of three indicators, namely: number of plants cited by young people and elders, therapeutic choice...
Source: Revista Brasileira de Farmacognosia - April 28, 2017 Category: Drugs & Pharmacology Source Type: research

Engineering spray-dried rosemary extracts with improved physicomechanical properties: a design of experiments issue
ABSTRACT A 33 Box – Behnken design and Response Surface Methodology were performed to evaluate the influence of extract feed rate, drying air inlet temperature and spray nozzle airflow rate on the process yield, stability parameters (moisture content and water activity) and on several physicomechanical properties of spray-dried rosemary extracts. Powder yield ranged from 17.1 to 74.96%. The spray-dried rosemary extracts showed moisture content and water activity below 5% and 0.5%, respectively, which indicate their chemical and microbiological stabilities. Even without using drying aids, some sets of experimental conditi...
Source: Revista Brasileira de Farmacognosia - April 28, 2017 Category: Drugs & Pharmacology Source Type: research

Inhibition of cytochrome P450 3A enzyme by Millettia aboensis: its effect on the pharmacokinetic properties of efavirenz and nevirapine
This study was designed to evaluate the effect of Millettia aboensis (Hook. f.) Baker, Fabaceae, on cytochrome P450 3A isoenzyme and the influence of this effect on the bioavailability of two antiretroviral agents. In vitro effect of ethanol extract of M. aboensis on intestinal and liver microsomes extracted from female rats was assessed using erythromycin-N-demethylation assay method while in vivo effects were determined by estimating simvastatin plasma concentrations in rats. The effect of the extract on pharmacokinetic parameters of orally administered efavirenz (25 mg/kg) and nevirapine (20 mg/kg) was determined in rat...
Source: Revista Brasileira de Farmacognosia - April 28, 2017 Category: Drugs & Pharmacology Source Type: research

Anti-inflammatory, and antinociceptive effects of Campomanesia adamantium microencapsulated pulp
ABSTRACT Guavira fruits have antimicrobial, antioxidant, antinociceptive, and anti-inflammatory activities. Spray drying has been widely used in the food industry presenting good retention in bioactive compounds used to transform the pulp/fruit juice into powder form. Therefore, the present study has evaluated the anti-inflammatory and antinociceptive activities of the microencapsulated pulp of Campomanesia adamantium (Cambess.) O.Berg, Myrtaceae, by spray drying. Different groups of mice were treated with the doses of 100 and 300 mg/kg of microencapsulated "guavira" pulp and inflammatory parameters were assessed in a carr...
Source: Revista Brasileira de Farmacognosia - April 28, 2017 Category: Drugs & Pharmacology Source Type: research

Heliopsis longipes: anti-arthritic activity evaluated in a Freund's adjuvant-induced model in rodents
This study assesses the anti-arthritic effect of the affinin-enriched (spilanthol, main alkamide) hexane extract from the roots of Heliopsis longipes (A. Gray) S.F. Blake, Asteraceae, on a Freund adjuvant-induced arthritis model in rodents. The extract was orally administered at a dose of 2, 6.6, or 20 mg/kg; a significant edema-inhibitory activity in the acute and chronic phases was observed with a dose of 2 and 20 mg/kg, respectively. The extract showed higher anti-inflammatory and anti-arthritic effects than the reference drug phenylbutazone (80 mg/kg). Moreover, the extract prevented the occurrence of secondary lesions...
Source: Revista Brasileira de Farmacognosia - April 28, 2017 Category: Drugs & Pharmacology Source Type: research