Revista Brasileira de Farmacognosia This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Impact of chrysosplenetin, per se or in combination with artemisinin, on breast cancer resistance protein (Bcrp)/ABCG2 mRNA expression levels in mice small intestine
This study, therefore, further addressed the impact of chrysosplenetin, per se or in combination with artemisin, on Bcrp/ABCG2 mRNA expression levels in mice small intestine determined by western blot and real time-quantitative polymerase chain reaction (RT-qPCR) assay. The drugs were intragastrically administrated once per day for 7 days. Novobiocin, a known Bcrp inhibitor, was observed to have no impact on Bcrp/ABCG2 levels with or without artemisinin versus vehicle. Interestingly, artemisinin alone attenuated Bcrp level while chrysosplenetin alone increased it (p< 0.05). Relative mRNA level was significantly decrease...
Source: Revista Brasileira de Farmacognosia - January 11, 2018 Category: Drugs & Pharmacology Source Type: research

Relative popularity level of medicinal plants in Talagang, Punjab Province, Pakistan
ABSTRACT This is the first ethnobotanical exploration with the aim to document the traditional medicinal usage of plants with the therapeutic values in Tehsil Talagang of Punjab province, Pakistan. The study shows the dependence of local people on medicinal plants in their daily life and provides practical evidence regarding the traditional usage of medicinal plants in health care practices. A total of 196 respondents including residents of the study area with gender representation and traditional healers were interviewed by using visual appraisal approach and rapid rural appraisal methods along semi-structured interviews ...
Source: Revista Brasileira de Farmacognosia - January 11, 2018 Category: Drugs & Pharmacology Source Type: research

Phytochemical composition and chronic hypoglycemic effect of Rhizophora mangle cortex on STZ-NA-induced diabetic rats
ABSTRACT Type 2 diabetes is a major health problem in Mexico, as it is in other countries, is a chronic condition that develops when the body cannot produce enough insulin or cannot use it appropriately. Both insulin deficiency and insulin resistance lead to high blood glucose levels. In Mexico, people with diabetes are known to use the decoction of red mangrove (Rhizophora mangle L., Rhizophoraceae) bark to control blood glucose levels. Therefore, in this study, we sought to investigate the chronic hypoglycemic and hypolipidemic effects of R. mangle; we also elucidate some of the major phytochemical compounds of R. mangle...
Source: Revista Brasileira de Farmacognosia - January 11, 2018 Category: Drugs & Pharmacology Source Type: research

In vitro antitubercular activity of extract and constituents from the stem bark of Disthemonanthus benthamianus
ABSTRACT A new C-glycosylflavone, apigenin 7-methyl ether 6-C-[ β -xylopyranosyl-(1 → 3)- β -glucopyranoside] named distemonanthoside was isolated from the stem bark of Distemonanthus benthamianus Baill., Fabaceae, along with six known compounds, sitosterol 3-O- β -D-glucopyranoside, 4-methoxygallic acid, syringic acid, quercetin, 6"-O-acetylvitexin, quercetin 3-O- β -D-glucopyranoside. The structures of those compounds and others were determined through spectral analyses. Compounds distemonanthoside, sitosterol 3-O- β -D-glucopyranoside, 4-methoxygallic acid and quercetin were tested against a clinical isolate stra...
Source: Revista Brasileira de Farmacognosia - January 11, 2018 Category: Drugs & Pharmacology Source Type: research

Aqueous extract of Baccharis trimera improves redox status and decreases the severity of alcoholic hepatotoxicity
ABSTRACT The metabolism of ethanol occurs mainly in the liver, promoting increase of reactive oxygen species and nitrogen, leading to redox imbalance. Therefore, antioxidants can be seen as an alternative to reestablish the oxidizing/reducing equilibrium. The aim of this study was to evaluate the antioxidant and hepatoprotective effect of aqueous extract of Baccharis trimera (Less.) DC., Asteraceae, in a model of hepatotoxicity induced by ethanol. The extract was characterized and in vitro tests were conducted in HepG2 cells. It was evaluated the cells viability exposed to aqueous extract for 24 h, ability to scavenging th...
Source: Revista Brasileira de Farmacognosia - January 11, 2018 Category: Drugs & Pharmacology Source Type: research

Isolation and identification of cytotoxic compounds from a fruticose lichen Roccella montagnei, and it's in silico docking study against CDK-10
ABSTRACT Roccella montagnei B él. belongs to lichen family Roccelleceae growing luxuriantly along the coastal regions of India. As Roccella has been shown to be bioactive, we prepared methanolic extract and assessed its anticancer potential. The methanolic extract showed significant in vitro cytotoxic activity against four huma n cancer cell lines such as colon (DLD-1, SW-620), breast (MCF-7), head and neck (FaDu). This prompted us to isolate bioactive compounds through column chromatography. Two compounds roccellic acid and everninic acid have been isolated, out of which everninic acid is reported for the first time. Bot...
Source: Revista Brasileira de Farmacognosia - January 11, 2018 Category: Drugs & Pharmacology Source Type: research

UPLC/Q-TOF-MS profiling of phenolics from Canarium pimela leaves and its vasorelaxant and antioxidant activities
ABSTRACT Canarium pimela K.D. Koenig, Burseraceae, have a long history of use in the Chinese traditional medicine treatment of various ailments including hypertension, and our research team has reported the anti-hypertensive activity and delineated the mechanism involved in the action. The following research aims to evaluate the vasorelaxant and antioxidant activities of ethanol extract from C. pimela leaves and to analyze its chemical composition by ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF-MS) that may correlate with their pharmacological activities. The results showe...
Source: Revista Brasileira de Farmacognosia - January 11, 2018 Category: Drugs & Pharmacology Source Type: research

Chemical constituents from Bauhinia acuruana and their cytotoxicity
ABSTRACT Phytochemical investigation of Bauhinia acuruana Moric., Fabaceae, resulted in the isolation of sixteen constituents, including two new compounds 2'-hydroxy-2,3,5-trimethoxybibenzyl (1), (2R,3S)-2-(3,4'-dihydroxyphenyl)-5-methoxy-6-methylchroman-3,7-diol (2), together with fourteen known ones (3 – 16). The structures of the compounds were established by spectroscopic analysis including HR-ESI-MS, 1D and 2D NMR data, followed by comparison with previously reported data from the literature. Compounds 1, 2, 6, 7, 8 and 9 were evaluated for their cytotoxicity, which turned out to be marginal in a panel of six human ...
Source: Revista Brasileira de Farmacognosia - January 11, 2018 Category: Drugs & Pharmacology Source Type: research

Biological activities and phytochemical profile of Passiflora mucronata from the Brazilian restinga
In conclusion, Passiflora mucronata presented relevant biological potential and should be considered for further studies using in vivo pulmonary tuberculosis model. (Source: Revista Brasileira de Farmacognosia)
Source: Revista Brasileira de Farmacognosia - January 11, 2018 Category: Drugs & Pharmacology Source Type: research

Plectraterpene, a new ursane-type triterpene ester and other steroids from the aerial parts of Plectranthus montanus
ABSTRACT A new ursane-type triterpene ester, plectraterpene [3 β -(decanoyloxy)-19-hydroxy-urs-12-ene] and four known steroidal compounds have been isolated from the aerial parts of Plectranthus montanus Benth. (syn. Plectranthus cylindraceus Hochst. ex Benth.), Lamiaceae. The known compounds were stigmasterol, sitosteryl ferulate, cholest-5-en-3-O- β -D-glucopyranoside and stigmasterol-3-O- β -D-glucopyranoside. Compounds plectraterpene, sitosteryl ferulate and stigmasterol-3-O- β -D-glucopyranoside are reported for the first time from this plant whereas compound cholest-5-en-3-O- β -D-glucopyranoside first time from...
Source: Revista Brasileira de Farmacognosia - January 11, 2018 Category: Drugs & Pharmacology Source Type: research

Simultaneous HPLC analysis of crebanine, dicentrine, stephanine and tetrahydropalmatine in Stephania venosa
ABSTRACT Stephania venosa (Blume) Spreng., Menispermaceae, has been traditionally used as tonic drug and treatment of various diseases in South East Asian countries. In order to evaluate the quality and standardization of S. venosa roots, the HPLC method for quantification of the content of major components in S. venosa was developed and validated. The chromatographic separation was performed on a Hypersil BDS C18 column using gradient system of 100 mM ammonium acetate in water and methanol with flow rate 1 ml/min. Detection wavelength was set at 210 nm for tetrahydropalmatine, 280 nm for dicentrine and crebanine, and 270 ...
Source: Revista Brasileira de Farmacognosia - January 11, 2018 Category: Drugs & Pharmacology Source Type: research

Influence of growth regulators on distribution of trichomes and the production of volatiles in micropropagated plants of Plectranthus ornatus
ABSTRACT The profile of volatile organic compounds, the glandular and non-glandular trichomes of Plectranthus ornatus, obtained by in vitro cultivation, was evaluated in plants grown in Murashide and Skoog medium supplemented with benylaminopurine at 4.5, 9.0, and 18.0 µM + naphthaleneacetic acid at 5.37 µM, kinetin at 4.7, 9.3 and 18.5 µM + naphthaleneacetic acid (5.37 µM) or Murashide and Skoog 0 medium (as a control). Scanning Electron Microscopy was performed on samples of the third leaf node of the 90 days old plants obtained from treatment with 4.5 or 9. 0 µM benylaminopurine, and 4.7 or 9.3 µM kinetin. Headspa...
Source: Revista Brasileira de Farmacognosia - January 11, 2018 Category: Drugs & Pharmacology Source Type: research

Leaf anatomy of Protium ovatum and its antiproliferative potential in cervical cells
ABSTRACT The aim of this study was to analyze the morphology and anatomy of the leaves of Protium ovatum Engl., Burseraceae, and verify the antiproliferative activity in cervical cells. For anatomical analysis, the leaf samples were fixed in formol, acetic acid, alcohol 70, dehydrated, included in hydroxyethyl methacrylate and sectioned at a thickness of 5 – 10 µm in rotative microtome. The samples were stained with toluidine blue and blades mounted with synthetic resin “ Entellan ” . Histochemical tests and scanning electron microscopy were also performed. To investigate the antiproliferative effect we used the cel...
Source: Revista Brasileira de Farmacognosia - January 11, 2018 Category: Drugs & Pharmacology Source Type: research

Vouacapane diterpenoids isolated from Pterodon and their biological activities
Abstract The Pterodon genus comprises two native species in Brazil, known as “ sucupira-branca ” or “ faveira ” . Their fruits have long been used in Brazilian natural medicine, mainly for the treatment of infections and inflammations. The pharmacological properties of these fruits have often been linked with vouacapane diterpenoids. This review evaluated the scientific research in the period from 1973 to February 2017, aiming to answer how difficult it still is to develop a scientifically supported product based on Pterodon vouacapanes. Therefore, this paper reviews purification, identification, and quantificatio...
Source: Revista Brasileira de Farmacognosia - November 17, 2017 Category: Drugs & Pharmacology Source Type: research

An overview of dermatological and cosmeceutical benefits of Diospyros kaki and its phytoconstituents
The objective of this article is to present cumulative data on potential use of D. kaki for its possible role in dermatologic and cosmetic applications. Scientific data has revealed an excellent position of D. kaki in both dermatology and cosmetic discipline making it a valuable choice in respective field. Active principles from different plant parts have shown to possess anti-inflammatory, antiallergic, photo-protective, and anti-wrinkle effects with appreciable activities against tyrosinase, elastase, and collagenase enzymes. Promising antioxidant activity and skin whitening potential, augmented by reduction in sebum con...
Source: Revista Brasileira de Farmacognosia - November 17, 2017 Category: Drugs & Pharmacology Source Type: research