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Anti-psychotic activity of aqueous root extract of Hemidesmus indicus- a time bound study in rats.
CONCLUSION: All these observations imply that Hemidesmusindicus extract possesses anti-psychotic activity in experimental animals. PMID: 27993107 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - December 21, 2016 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Addressing the Challenge of Developing a Physiologically Relevant Dissolution Test for Regulatory Purposes.
Authors: Gray V Abstract The challenge of developing a physiologically relevant dissolution test to satisfy regulatory agencies has pushed drug manufacturers to engage in "design of experiment" method development, which helps manufacturers address variability, dissolution medium, and surfactant use-all of which will influence dissolution. PMID: 27855615 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - November 21, 2016 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Multi-particulate Systems: Cutting-edge Technology for Controlled Drug Delivery.
CONCLUSION: Comprehensive knowledge of these technologies will expedite further development and platform technologies for multi-particulate controlled drug delivery systems. PMID: 27809755 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - November 5, 2016 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Self-emulsifying Pellets Prepared by Extrusion/Spheronization: In vitro/In vivo Evaluation.
CONCLUSION: In conclusion, spherical pellets with low friability and self-emulsifying properties can be produced by the standard extrusion/spheronization technique. The pellets are capable of transferring lipophilic compounds into the aqueous phase and have a high potential to increase the oral absorption of lipophilic drugs. PMID: 27774911 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - October 26, 2016 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Development of self emulsifying formulations of poorly soluble naproxen for enhanced drug delivery.
Conclusion The optimized formulation was found to be stable for 6 months during stability studies conducted according to the ICH Q1A (R2) guidelines. Thus this developed self emulsifying drug delivery system may be a useful tool to enhance the solubility of oral poorly water soluble drug naproxen. PMID: 27774912 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - October 26, 2016 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Development and Optimization of Controlled Porosity Osmotic Tablets of Lamotrigine Solid Dispersion.
CONCLUSION: The present results confirmed that prepared LTG SD serves as solubility modulator. Further, CPOT of LTG based on SD proved to be successful in delivering the drug in a controlled manner ensuring the once daily dosing for the treatment of convulsive disorders. PMID: 27712567 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - October 11, 2016 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Formulation Development And Optimization Of Matrix Tablet of Tramadol Hydrochloride.
CONCLUSION: Double granulation technique with CW and HPMC K100 proved as a better technique for sustaining the drug release from the matrix tablet. PMID: 27712568 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - October 11, 2016 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Liposomal drug delivery system for cancer therapy: Advancement and Patents.
Authors: Jha S, Sharma P, Malviya R Abstract In this review article, authors reviewed about the liposomes which are amongst various drug delivering systems for the delivery of the therapeutic agents at the target site. Advances in liposomal drug delivery systems for the cancer therapy have enhanced the therapeutic levels of the anticancer moieties. Liposomes show promising action on the tumor by incorporating less amount of drug at the target site, with minimum toxic effect and maximum therapeutic effect and thereby enhancing the bioavailability. Liposome- based drug delivery systems provide the potential ...
Source: Recent Patents on Drug Delivery and Formulation - October 11, 2016 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Impact of Pluronic F-68 vs Tween 80 on Fabrication and Evaluation of Acyclovir SLNs for Skin Delivery.
Authors: Newton MJ, Kaur B Abstract The solid lipid nanoparticles (SLNs) of Acyclovir (ACV) were fabricated with Soya lecithin and Fractionated Coconut oil (medium chain glyceride) as a first time combination. The research was focused on developing ACV-SLN by using high pressure hot-homogenization technique. The ingredients were used in different concentrations and ratios to identify the best formulation design. The tween 80 and Pluronic F-68 were used in various concentrations in formulation design to assess the impact on the fabrication and evaluation of SLNs. The SLNs were subjected to various character...
Source: Recent Patents on Drug Delivery and Formulation - July 29, 2016 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Quality by Design (QbD) Approach for Development of Co-Processed Excipient Pellets (MOMLETS) By Extrusion-Spheronization Technique.
CONCLUSION: Co-processed excipient core pellets (MOMLETS) were successfully developed by QbD approach. Versatility, Industrial scalability and simplicity are the main features of the proposed research. PMID: 27396400 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - July 13, 2016 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Preface.
Authors: Donnelly RF PMID: 27398423 [PubMed - in process] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - July 13, 2016 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Nanosized Drug Delivery Systems for Direct Nose to Brain Targeting: A Review.
CONCLUSION: However, it is not yet confirmed whether the drug is freed from the formulation in the nasal cavity and then absorbed or the nanoparticles themselves are absorbed and then the drug is released in the CNS. Furthermore, the toxicity studies were not carried out extensively in suitably designed model, which should be considered before going for further studies and application. PMID: 26996366 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - March 23, 2016 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Pharmacological Effect of Berberine Chloride in Propyl Thiouracil Induced Thyroidal Dysfunction - A Time Bound Study in Female Rats.
Conclusion From the findings of the current study it can be concluded that berberine chloride possesses both thyroid stimulating and suppressing activities depending on its dose, especially berberine chloride 50 mg/kg supports thyroid stimulating property. PMID: 26996367 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - March 23, 2016 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Approaches and Recent Trends in Gene Delivery for Treatment of Atherosclerosis.
CONCLUSION: In view of the many limitations in employing viral vectors for delivery, designing non-viral vectors for successful delivery of therapeutic gene in atherosclerosis should be realized and focused for effective management of the disease. PMID: 26927413 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - March 3, 2016 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

The use of propolis in micro/nanostructured pharmaceutical formulations.
CONCLUSION: Many papers and submitted or granted patent applications were found, reporting from extraction method for propolis, which provides new possibilities for incorporation of propolis components in micro/nanostructured cosmetic products, foodstuffs and medicines. PMID: 26715146 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - January 15, 2016 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research