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An Overview On Various Approaches And Recent Patents On Gastroretentive Drug Delivery Systems.
Authors: Kumar M, Kaushik D Abstract Drugs having absorption window in the stomach or upper small intestine has restricted bioavailability with conventional dosage forms. The gastric residence time of these dosage forms is usually short and they do not show drug release for prolonged period of time. To avoid these problems and to enhance the bioavailability and gastric retention time of these drugs, controlled drug delivery systems with prolonged gastric retention time are currently being developed. This review highlights the various pharmaceutical approaches for gastroretention such as floating drug deliv...
Source: Recent Patents on Drug Delivery and Formulation - March 11, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Development of Microemulsion Based Nabumetone Transdermal Delivery For Treatment of Arthritis.
Conclusion Nabumetone microemulgel exhibiting good in-vitro and ex-vivo controlled drug release was optimized. PMID: 29485013 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - March 1, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Formulation And In-Vitro And Ex-Vivo Evaluation Of Tretinoin Loaded Cubosomal Gel For Acne Treatment.
CONCLUSION: At the end, it can be concluded that cubosomes offer benefits of quick onset as well as the maximal release of drug with fewer side effects. Thus, cubosomes represents a capable transporter having the property of sustained release of the drug, potential to localize the drug in the skin with a possible clinical application for acne vulgaris treatment due to cubosome depot effect on the epidermis. PMID: 29437029 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - February 15, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Novel Ternary Polymeric Blends for Controlled Release Matrices Containing Weakly Basic Model Drug.
The objective of this study was to evaluate the suitability of a novel matrix tablet formulation made of ternary mixture of smart polymers comprised of Eudragit®E100, Eudragit®L100, and sodium alginate to sustain the release of a weakly basic drug Metronidazole. Recent patents on Metronidazole controlled/sustained release matrices include US7790755, US8784885, US8628797 and US7476403. Matrix tablets formulations were prepared by either direct compression or by wet granulation. Dissolution studies were conducted using USP XXΠ rotating paddle apparatus at paddle speed of 50 rpm, and dissolution medium temperature at 37°C...
Source: Recent Patents on Drug Delivery and Formulation - January 24, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Crystalline ethylene oxide and propylene oxide triblock copolymer solid dispersion enhance solubility, stability and promoting time-controllable release of Curcumin.
CONCLUSION: Thus, these SDs, specifically CUR:P-407 1:2 w/w, can overcome the barriers of poor bioavailability to reap its many beneficial properties. PMID: 29345599 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - January 20, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Editorial.
Authors: Donnelly RF PMID: 29332561 [PubMed - in process] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - January 17, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

A New Approach To Enhance The Solubility Of Famotidine Tablet By Using Naturally Isolated Pear Starch.
CONCLUSIONS- The results from various evaluations show that pear starch has significant binding characteristics. Hence it can be used as tablet binder in pharmaceutical formulations. PMID: 29303081 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - January 7, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Aripiprazole-Loaded Polymeric Micelles: Fabrication, Optimization and Evaluation using Response Surface Method.
CONCLUSION: It is concluded that the prepared polymeric micellar system has an excellent potentialto be used as delivery carrier for Aripiprazole with increased solubility. PMID: 29303082 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - January 7, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Patented and approval scenario of nanopharmaceuticals with relevancy to biomedical application, manufacturing procedure and safety aspects.
Authors: Agarwal V, Bajpai M, Sharma A Abstract A term 'nanopharmaceuticals' give the emphasis on the discovery, development and delivery of the drugs to the specific site using different delivery systems. Nanopharmaceutical field is a thrust area in which the development is going on progressively but the many new challenges are also arises continuously, such as regulatory requirements, identification of therapeutic targets, cost-effective and efficient tools for delivering the drug, standardization of different characterization method, etc. Some products related to this area that can be consistently and r...
Source: Recent Patents on Drug Delivery and Formulation - January 7, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Chronopharmacokinetic Evaluation of Budesonide Multiparticulate Systems.
Authors: Battu S, Yalavarthi PR, Subbareddy GV, Rao UM, Katamreddy JD, Vadlamudi HC Abstract Poor oral absorption of budesonide limits design of its solid oral dosage form. With this context, multiparticulate pulsatile system of budesonide for chronotherapy of nocturnal asthma was aimed in this study. Initially, solid dispersions of budesonide (BD) using sodium starch glycolate (SSG) and guar gum (GG) were developed and characterized. Uniform sized non-pariel seeds (~400 µm) were coated with solid dispersions to obtain immediate (BMP) and controlled release pellets by solution layering technique. Pulsatil...
Source: Recent Patents on Drug Delivery and Formulation - December 15, 2017 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Natural product formulations for prevention and treatment of Alzheimer's disease: a patent review.
CONCLUSION: It is becoming now well accepted that multiple factors contribute to the progression of AD. The pathogenesis of the disease involves amyloid-β cascade, tau hyperphosphorylation, oxidative stress, inflammation, mitochondrial dysfunction, protein misfolding, gene mutation, etc. It has been suggested that the multifactorial nature of AD pathogenesis requires the design of medicines with a wide spectrum of activity. Medicinal herbs are known to consist of multiple compounds and may influence multiple mechanisms, thus being advantageous over the simple single-target drugs in the treatment of complex diseases. Indee...
Source: Recent Patents on Drug Delivery and Formulation - December 10, 2017 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Enhanced both in vitro and in vivo kinetics by SLNs induced transdermal system of furosemide: A novel approach.
CONCLUSIONS: The SLNs induced transdermal patch was found to beneficial in enhancing kinetic properties both in-vitro and in-vivo. PMID: 29189185 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - December 1, 2017 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Furosemide - Soluplus ® Solid Dispersion: Development and Characterization.
Furosemide - Soluplus® Solid Dispersion: Development and Characterization. Recent Pat Drug Deliv Formul. 2017 Nov 29;: Authors: Patwa R, Praveen R, Singh SK, Verma PRP Abstract Recent patents reveal that Soluplus® has proved to be a promising excipient that modulates dissolution characteristics of many active pharmaceutical ingredients (WO 2016161995 A1, WO 2016169534 A1, WO 2016165676 A1). Current article investigate on stable solid solution of furosemide with Soluplus to enhance the dissolution properties of the drug. Drug:carrier ratios to prepare solid dispersion was selecte...
Source: Recent Patents on Drug Delivery and Formulation - December 1, 2017 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Thymoquinone (TQ) a potential therapeutic molecule: Role of colloidal carriers in its effective delivery.
Authors: Negi P, Rathore C, Sharma G, Bhoop BS, Katare OP Abstract From the past few decades, remarkable awareness has been laid on the use of herbal medicines in pharmaceutical research. Thymoquinone (TQ), the main chemical constituent of Nigella sativa (NS) plant has been extensively explored and revealed an array of therapeutic benefits in different in vitro and in vivo conditions. This review provides brief outline of the diverse therapeutics actions of TQ and NS viz. anti-oxidant, anti-inflammatory, anti-cancer, anti-diabetic, gastro-protective, hepato-protective, anti-microbial and anti-histaminic. B...
Source: Recent Patents on Drug Delivery and Formulation - December 1, 2017 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Phytochemicals Formulated as Nanoparticles: Inventions,Recent Patents and Future Prospects.
CONCLUSION: If bioavailability constraint is overcome, diseases like cancer, alzheimer, diabetes, liver disorder etc. can be effectively targeted. By doing so, the largely affected society, will breathe the relief. The present article is an attempt to elaborate and conclude on how nanoparticles have been serving as a tool to enhance the effectiveness of phytochemicals, by solubilization, dissolution and consequent bioavailability enhancements, along with in vivo targeting. To further facilitate understanding, the review has been structured as disease/disorder and phytochemical wise with focus on their nanoparticles. ...
Source: Recent Patents on Drug Delivery and Formulation - November 24, 2017 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research