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Nanocapsules for Drug Delivery: An Updated Review of the Last Decade.
CONCLUSION: The present study discusses and summarizes patents related to preparation methods of and recent studies from the last 10 years on nanocapsules as drug delivery systems. PMID: 30674269 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - January 26, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Review of Recent Patents and Developments in Skeletal Muscle Regeneration.
Authors: Wang J, Wang GQ, Wang H, Chen QM, Burczynski FJ Abstract Skeletal muscle is a highly-specialized tissue that is capable of contractile function and able to withstand and adapt to daily mechanical and physiological stress. Musculoskeletal disorders, including muscular dystrophies, result in chronic pain and disability, reduced quality of life, burden on family, and increased healthcare costs. Although several mechanisms have been identified for muscle injury and regeneration, mechanisms of these diseases are poorly understood, and targeted and effective pharmacologic treatment(s) not available. Mor...
Source: Recent Patents on Drug Delivery and Formulation - January 5, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Montelukast Sodium Formulation containing Green Tea Extract to Reduce the Oxidative Stress in Guinea Pig model of Chronic Allergic Asthma.
CONCLUSION: It is contemplated that, use of GTE as an adjuvant to anti leukotriene drug played a significant role in asthma management by reducing oxidant injury. Since, studies in animals do not directly translate to human biology, further multi-control studies with better sampled patient population and more number of patients is needed. PMID: 30539707 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - December 14, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Mesoporous silica nanoparticles: a versatile platform for biomedical applications.
CONCLUSION: The future success of MSNs is widened because of their valuable characteristic which easily combines with various functionalities which would display enormous potential translational possibilities. PMID: 30501606 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - December 8, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

The Unprecedented Role of Gold Nonmaterial in Diabetes Management.
CONCLUSION: Gold nanoparticles have proved themselves useful in diabetes therapeutics and diagnostics. Due to low inherent toxicity, and high surface area, gold nanoparticles have become a unique aspect of the delivery approach. The key issue that needs to be addressed is the bio pharmaceutics, biocompatibility, and potential clinical applications. PMID: 30430950 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - November 17, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Self-Emulsifying Drug Delivery System of Simvastatin: Formulation Development, Optimization by Box- Behnken Design, In-Vitro and In-Situ Single-Pass Intestinal Perfusion (SPIP) Studies.
CONCLUSION: SIM SEDDS were successfully developed and evaluated for in-vitro & in-vivo parameters. All the evaluated parameters were in tolerable limits. In vitro release studies from optimized formulation, OF1, exhibited maximum drug release when compared to SIM API and marketed preparation. Moreover, the predicted value of fraction absorbed (Fa) in humans by in-situ SPIP method were also in agreement with in-vitro dissolution studies thus, confirming SEDDS as a suitable drug delivery system for solubility enhancement of SIM. PMID: 30345934 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug De...
Source: Recent Patents on Drug Delivery and Formulation - October 24, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Role of Porous Carriers in the Biopharmaceutical Performance of Solid Self-microemulsion Preconcentrates of Canagliflozin1.
CONCLUSION: The present investigation reveals immense potential of solid SMEDDS in augmenting the oral bioavailability profile of poorly water soluble drug canagliflozin. PMID: 30295193 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - October 10, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Antibacterial and in vitro growth inhibition study of struvite urinary stones using Oxalis corniculata Linn. leaf extract and its biofabricated silver nanoparticles.
CONCLUSION: The present work confirms the inhibitory activity of the aqueous extract of edible O. corniculata and its biofabricated silver nanoparticles against urinary tract infection (UTI) causing bacteria and urolithiasis. Therefore, the consumption of O. corniculata in our daily diet may reduce the risk of UTI and urolithiasis. PMID: 30039767 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - July 27, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Clinical application of polysialylated therapeutic proteins.
Authors: Meng H, Lockshin C, Jain S, Shaligram U, Martinez J, Genkin D, Hill DB, Ehre C, Clark D, Hoppe H Abstract While protein therapeutics are invaluable in managing numerous diseases, many require frequent injections to maintain therapeutically effective concentrations, due to their short half-life in circulation. PolyXen™, a platform technology employing biodegradable, non-immunogenic and hydrophilic polysialic acids (PSA) for drug delivery, is being utilized to overcome such limitations, thereby enabling the clinical utility of a broad range of protein therapeutics. Here, we report the recent progr...
Source: Recent Patents on Drug Delivery and Formulation - July 20, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Preparation, Characterization and In Vivo Assessment of Repaglinide Nanosuspension for Oral Bioavailability Improvement.
CONCLUSION: The outcomes of the study revealed significant enhancement in dissolution rate and oral bioavailability of RPG due to size reduction to nano range by HPH. PMID: 30003863 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - July 15, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Comparative Study on Photodynamic Activation of Ortho-Toluidine Blue and Methylene Blue Loaded Mesoporous Silica Nanoparticles Against Resistant Microorganisms.
CONCLUSION: MB and O-TB adsorbed on APTES functionalized mesoporous silica nanoparticles were capable of efficiently inactivating E. coli, P. aeruginosa, S. aureus bacteria upon exposure to red light (620± 20nm wavelength) at a much lower concentration. Mesoporous silica nanoparticles played an important role in aPDT due to its high surface area and porous structure. Also APTES functionalization resulted in the pore expansion of MSN, thereby increasing the loading capacity of the photosensitizer on MSN. From the results obtained it can be concluded that O-TB loaded MSN showed higher activity against all three gram negativ...
Source: Recent Patents on Drug Delivery and Formulation - June 30, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Preface.
Authors: Donnelly RF PMID: 29879875 [PubMed - in process] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - June 9, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Patent Selections.
Authors: PMID: 29879876 [PubMed - in process] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - June 9, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Orodispersible films: A systematic patent review.
CONCLUSION: It was observed that judicial selection of polymers and polymers blends and method of preparation are key parameters in formulation of orodispersible film. PMID: 29745346 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - May 11, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Nanocarriers for the Effective Treatment of Cervical Cancer: Research Advancements and Patent Analysis.
CONCLUSION: Nanocarriers results in transforming drug distribution that can overpower drug resistance. Further, nanocarriers based drug delivery systems can particularly target drugs to cellular, subcellular and tissue sites. By enhancing the drug's bioavailability at the desired site, these systems result in therapeutic benefits like enhanced safety and efficacy. Also, in combination with other treatment approaches like radiation, photothermal and gene therapy, nanocarriers are reported to be quite effective and can define novel strategies to combat cervical cancer. PMID: 29611489 [PubMed - as supplied by publishe...
Source: Recent Patents on Drug Delivery and Formulation - April 4, 2018 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research