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Development of the modified Occimum gratissimum seeds for orally disintegrating tablets.
CONCLUSIONS: The modified OGS demonstrated that it is a potential material with the advantages of cost-effectiveness, non-toxicity and easy manufacture in the preparation of ODTs. PMID: 31660821 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - October 31, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Nutraceuticals' Novel Formulations: The Good, the Bad, the Unknown and Patents Involved.
The objective of this review is to assess the current patents and research adopting novel formulation strategies in nutraceuticals and cosmeceuticals. Patents and research papers investigating nutraceutical and cosmeceutical novel formulations were surveyed for the past 15 years. Various nanosystems and advanced biotechnology systems have been introduced to improve the therapeutic efficacy, safety and market appeal of nutraceuticals and cosmeceuticals, including liposomes, polymeric micelles, quantum dots, nanoparticles, and dendrimers. This review provides an overview of nutraceuticals and cosmeceuticals current technolog...
Source: Recent Patents on Drug Delivery and Formulation - October 4, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Nanoantibiotic formulations to combat antibiotic resistance - Old wine in a new bottle.
Authors: Awasthi R, Rana R, Sharma B, Kulkarni GT Abstract BACKGROUND: Antibiotic resistance is becoming one of the major obstacles to treatment success in various pathological conditions. Development process of a new antimicrobial agent is slow and difficult, whereas bacterial resistance is decreasing the arsenal of existing antibiotics. Therefore, there is a need to develop novel antibiotic formulations to combat the resistance of existing antibiotics. Nanoparticles are investigated as novel antibiotic formulation, but are often inefficient in practical applications. Nanotechnology presents a new frontie...
Source: Recent Patents on Drug Delivery and Formulation - September 25, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Scientific Papers and Patents on Substances with Unproven Effects. Part 2.
In conclusion, placebo therapies can be beneficial and ethically justifiable but it is not a sufficient reason to publish biased information. Importantly, placebo must be devoid of adverse effects, otherwise it is named pseudo-placebo. Therapeutic methods with unproven effects should be tested in high quality research shielded from the funding bias. Some issues discussed in this review are not entirely clear, and the arguments provided here can initiate a constructive discussion. PMID: 31424374 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - August 20, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Preface.
Authors: Giovagnoli S Abstract PMID: 31418343 [PubMed - in process] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - August 18, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Nanosuspension Technology: Recent Patents on Drug Delivery and Their characterizations.
CONCLUSION: Nanosuspension contributes a crucial role in administering the different drug entities through a variety of routes involves oral, transdermal, ocular, parenteral, pulmonary, etc. with solving the different issues. This review also confirms the significance of nanosuspension in safety, efficacy, and communal as well as the economic expense associated with healthcare. PMID: 31203813 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - June 19, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Application of Optimization Technique to Develop Nano-Based Carrier of Nigella Sativa Essential Oil: Characterization and Assessment.
Authors: Dawaba AM, Dawaba HM Abstract BACKGROUND: Chitosan, a naturally occurring polymer, has interesting applications in the field of drug delivery due to its plentiful advantages as biodegradability, biocompatibility and nontoxic nature. Nigella Sativa essential oil is unstable, volatile, and insoluble in water and these problems confine its usage in developing new medicines. OBJECTIVE: this study focuses on developing a chitosan-based nanocarrier for the encapsulation of Nigella Sativa essential oil. By using Quality by design outline, the quality target product outline, critical quality attri...
Source: Recent Patents on Drug Delivery and Formulation - May 18, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Pharmaceutical Cocrystal: A Novel Approach to Tailor the Biopharmaceutical Properties of a Poorly Water Soluble Drug.
Authors: Srivastava D, Fatima Z, Kaur CD, Tulsankar SL, Nashik SS Abstract AIM AND BACKGROUND: The present study reports the formation of a cocrystal of candesartan with the coformer methyl paraben,its characterization and determination of its bioavailability.Candesartan is a poorly water soluble drug having an anti-hypertensive activity. The recent patents on the cocrystals of the drugs Progesterone (US9982007B2), Epalrestat (EP2326632B1), Gefitinib (WO2015170345A1), Valsartan(CN102702118B) for enhancement of solubility helped in selection of the drug for this work. METHODS: Candesartan cocrystal ...
Source: Recent Patents on Drug Delivery and Formulation - March 9, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Scientific Papers and Patents on Substances with Unproven Effects.
Authors: Jargin SV Abstract It is evident from reviewing of scientific literature that the quality of argumentation in some areas of medical research has deteriorated during last decades. Publication of series of questionable reliability have been continued without making references to the published criticism; examples are discussed in this review. Another tendency is that drugs without proven efficiency are advertised, corresponding products patented and marketed as evidence-based medications. Professional publications are required to register drugs and dietary supplements to obtain permissions for the pr...
Source: Recent Patents on Drug Delivery and Formulation - March 9, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Synthesis and characterization of Valcyclovir HCl hybrid solid lipid nanoparticles by using Natural oils.
Authors: Archana C, Amaldoss MJN Abstract BACKGROUND: The Jojoba Simmondsia Chinensis oil is used as one of the main ingredients which have an antioxidant, moisturizing and stabilizing activity. Likewise, grape seed (Vitis vinifera) oil is also used in this preparation which also has some remarkable medicinal properties such as antioxidant, astringent and as a moisturizer. The Valacyclovir solid lipid nanoparticles (SLN) were prepared in combination. OBJECTIVE: The prime objective of the study is to prepare a nano dispersion with good stability indicating zeta potential. The formulations were prepa...
Source: Recent Patents on Drug Delivery and Formulation - March 8, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Bilayer Tablet Based Chronotherapeutics in the Management of Nocturnal Asthma: An Overview.
CONCLUSION: The practice of nanotechnology in the arena of medicine will transform the strategies of detection and treatment of a wide range of diseases in the upcoming years. The findings of this review confirm the importance of bilayer tablet based chronotherapy in nocturnal asthma. PMID: 30827275 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - March 5, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Progress in Drug and Formulation development for Chemoprevention of Oral Squamous Cell Carcinoma: A review.
CONCLUSION: Use of chemopreventive agents, either synthetic or natural origin, to prevent carcinogenesis is a worthy concept in the management of cancers. Preventive measures are helpful in controlling the occurrence or severity of the disease. The demonstrated results of preventive agents have opened an arena for the development of promising chemopreventive agents in the management of oral squamous cell carcinoma. PMID: 30806332 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - February 28, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Nanocarriers for vaginal drug delivery.
CONCLUSION: Recently nanotechnology based drug delivery approach has promised better therapeutic outcomes by providing enhanced permeation and sustained drug release activity. Different nanoplatforms based on drugs, peptides, proteins, antigens, hormones, nucleic material, and microbicides are gaining momentum for vaginal therapeutics. PMID: 30767755 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - February 16, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

A review on enteric coated pellets composed of core pellets prepared by extrusion-spheronization.
Authors: Patel H, Gohel M Abstract Enteric coated dosage form bypasses the stomach and releases the drug into the small intestine. Advantages of enteric coated pellets in comparison with enteric coated tablets are a) Pellets provide rapid onset of action and faster drug release due to the smaller size than tablets and b) Pellets exhibits less residence time of acid-labile drugs in the stomach compared to tablets. Dosage form coat can be damaged by longer resistance time in the stomach. The present review summarizes the current state of enteric coated pellets where core pellets are prepared by extrusion-sph...
Source: Recent Patents on Drug Delivery and Formulation - February 13, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Design, Development and In vitro/Ex vivo Evaluation of Mucoadhesive Buccal Film of Benzydamine Hydrochloride for the Effective Treatment of Aphthous Stomatitis.
CONCLUSION: The developed mucoadhesive buccal film having adequate physicochemical properties was capable to provide prolonged residence time and sustained delivery as compared to existing conventional therapies. PMID: 30706830 [PubMed - as supplied by publisher] (Source: Recent Patents on Drug Delivery and Formulation)
Source: Recent Patents on Drug Delivery and Formulation - February 4, 2019 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research