Chronopharmacokinetic Evaluation of Budesonide Multiparticulate Systems.

Chronopharmacokinetic Evaluation of Budesonide Multiparticulate Systems. Recent Pat Drug Deliv Formul. 2017 Dec 12;: Authors: Battu S, Yalavarthi PR, Subbareddy GV, Rao UM, Katamreddy JD, Vadlamudi HC Abstract Poor oral absorption of budesonide limits design of its solid oral dosage form. With this context, multiparticulate pulsatile system of budesonide for chronotherapy of nocturnal asthma was aimed in this study. Initially, solid dispersions of budesonide (BD) using sodium starch glycolate (SSG) and guar gum (GG) were developed and characterized. Uniform sized non-pariel seeds (~400 µm) were coated with solid dispersions to obtain immediate (BMP) and controlled release pellets by solution layering technique. Pulsatile drug release pellets (BMPP) were obtained by coating the controlled release pellets with Eudragit L100 and RS 100. Pellets were assessed by saturation solubility, FTIR, DSC, micromeritic, SEM, drug content, drug release, pharmacokinetic and stability studies. Solubility of BD was increased by 22 folds due to inter-particle distribution of BD and polymers in solid dispersions. No changes in characteristic functional groups of BD had indicated the compatibility of drug with polymers as noticed in FTIR and DSC. Fluidized bed processor enabled the production of spherical and uniformly distributed pellets with optimum angle of repose (12-19º) and friability (<1%). Solution layering technique employed in preparation o...
Source: Recent Patents on Drug Delivery and Formulation - Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research