microRNA dysregulation in neurodegenerative diseases: A systematic review
Publication date: Available online 26 July 2019Source: Progress in NeurobiologyAuthor(s): Camille A. Juźwik, Sienna S. Drake, Yang Zhang, Nicolas Paradis-Isler, Alexandra Sylvester, Alexandre Amar-Zifkin, Chelsea Douglas, Barbara Morquette, Craig S. Moore, Alyson FournierAbstractWhile the root causes for individual neurodegenerative diseases are distinct, many shared pathological features and mechanisms contribute to neurodegeneration across diseases. Altered levels of microRNAs, small non-coding RNAs involved in post transcriptional regulation of gene expression, are reported for numerous neurodegenerative diseases. Yet,...
Source: Progress in Neurobiology - July 28, 2019 Category: Neuroscience Source Type: research
Time for the systems-level integration of aging: Resilience enhancing strategies to prevent Alzheimer’s disease
Publication date: Available online 25 July 2019Source: Progress in NeurobiologyAuthor(s): Harald Hampel, Simone Lista, Christian Neri, Andrea Vergallo, for the Alzheimer Precision Medicine Initiative (APMI)AbstractSystems biology and systems neurophysiology generate comprehensive mechanistic models of the spatial-temporal evolution of body system networks and their interplay during the dimensional spectrum from physiological to pathophysiological conditions.Alzheimer’s disease (AD)-related pathophysiological alterations converge with overexpressed age-related functional decline, i.e. aging, which is induced by genetic- a...
Source: Progress in Neurobiology - July 27, 2019 Category: Neuroscience Source Type: research
Mitochondrial degradation of amyloidogenic proteins — A new perspective for neurodegenerative diseases
Publication date: Available online 10 July 2019Source: Progress in NeurobiologyAuthor(s): Janin Lautenschäger, Gabriele S. Kaminski SchierleAbstractThis perspective article outlines mechanisms of mitochondrial import and protein degradation and how these have been linked to alpha-synuclein and Amyloid beta (Aβ) homeostasis. Our aim is to underpin and stimulate the debate on the recent conception of mitochondria as protein degrading organelles, which suggests that mitochondria are more directly involved in neurodegenerative diseases than previously assumed. (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - July 25, 2019 Category: Neuroscience Source Type: research
False positives from impurities result in incorrect functional characterization of receptors in chemosensory studies
Publication date: Available online 13 July 2019Source: Progress in NeurobiologyAuthor(s): Dirk Louis P. Schorkopf, Béla Péter Molnár, Marit Solum, Mattias C. Larsson, Jocelyn G. Millar, Zsolt Kárpáti, Teun DekkerAbstractThe discovery of chemoreceptors and technological advances have greatly increased our understanding of chemosensory mechanisms. However, some of this rapid progress may have been severely compromised by insufficient attention given to the possible effects of impurities in the chemical standards used in identifying ligands for target receptors. Here, we show that even trace amounts of impurities in test...
Source: Progress in Neurobiology - July 14, 2019 Category: Neuroscience Source Type: research
Mitochondrial Degradation of Amyloidogenic Proteins—A New Perspective for Neurodegenerative Diseases
Publication date: Available online 10 July 2019Source: Progress in NeurobiologyAuthor(s): Janin Lautenschäger, Gabriele S. Kaminski SchierleAbstractThis perspective article outlines mechanisms of mitochondrial import and protein degradation and how these have been linked to alpha-synuclein and Amyloid beta (Aβ) homeostasis. Our aim is to underpin and stimulate the debate on the recent conception of mitochondria as protein degrading organelles, which suggests that mitochondria are more directly involved in neurodegenerative diseases than previously assumed. (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - July 11, 2019 Category: Neuroscience Source Type: research
The function of connectomes in encoding sensory stimuli
Publication date: Available online 27 June 2019Source: Progress in NeurobiologyAuthor(s): Stéphane Molotchnikoff, Vishal Bharmauria, Lyes Bachatene, Nayan Chanauria, Jose Fernando Maya-VetencourtAbstractThe enormous number of neurons and the massive sum of connecting fibers linking them make the neural processes of encoding sensory signals extraordinarily complex, and this challenge is far from being elucidated. Simply stated, for the present paper, the question is — how does the brain encode complex images? Our proposal argues that modulation of strengths of functional relationships between firing neurons in relation t...
Source: Progress in Neurobiology - June 29, 2019 Category: Neuroscience Source Type: research
Editorial Board
Publication date: August 2019Source: Progress in Neurobiology, Volume 179Author(s): (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - June 26, 2019 Category: Neuroscience Source Type: research
Four-repeat tauopathies
Publication date: Available online 22 June 2019Source: Progress in NeurobiologyAuthor(s): Thomas W. Rösler, Amir Tayaranian Marvian, Matthias Brendel, Niko-Petteri Nykänen, Matthias Höllerhage, Sigrid C. Schwarz, Franziska Hopfner, Thomas Koeglsperger, Gesine Respondek, Kerstin Schweyer, Johannes Levin, Victor L. Villemagne, Henryk Barthel, Osama Sabri, Ulrich Müller, Wassilios G. Meissner, Gabor G. Kovacs, Günter U. HöglingerAbstractTau is a microtubule-associated protein with versatile functions in the dynamic assembly of the neuronal cytoskeleton. Four-repeat (4R-) tauopathies are a group of neurodegenerative dise...
Source: Progress in Neurobiology - June 24, 2019 Category: Neuroscience Source Type: research
Roles of Forkhead Box O (FoxO) Transcription Factors in Neurodegenerative Diseases: A panoramic view
Publication date: Available online 20 June 2019Source: Progress in NeurobiologyAuthor(s): Wei Hu, Zhi Yang, Wenwen Yang, Mengzhen Han, Baoping Xu, Zihao Yu, Mingzhi Shen, Yang YangAbstractNeurodegenerative diseases (NDDs), which are among the most important aging-related diseases, are typically characterized by neuronal damage and a progressive impairment in neurological function during aging. Few effective therapeutic targets for NDDs have been revealed; thus, an understanding of the pathogenesis of NDDs is important. Forkhead box O (FoxO) transcription factors have been implicated in the mechanisms regulating aging and l...
Source: Progress in Neurobiology - June 21, 2019 Category: Neuroscience Source Type: research
Neuregulin-1/ErbB Network: An Emerging Modulator of Nervous System Injury and Repair
Publication date: Available online 20 June 2019Source: Progress in NeurobiologyAuthor(s): Hardeep Kataria, Arsalan Alizadeh, Soheila Karimi-AbdolrezaeeAbstractNeuregulin-1 (Nrg-1) is a member of the Neuregulin family of growth factors with essential roles in the developing and adult nervous system. Six different types of Nrg-1 (Nrg-1 type I-VI) and over 30 isoforms have been discovered; however, their specific roles are not fully determined. Nrg-1 signals through a complex network of protein-tyrosine kinase receptors, ErbB2, ErbB3, ErbB4 and multiple intracellular pathways. Genetic and pharmacological studies of Nrg-1 and ...
Source: Progress in Neurobiology - June 21, 2019 Category: Neuroscience Source Type: research
Editorial Board
Publication date: July 2019Source: Progress in Neurobiology, Volume 178Author(s): (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - June 15, 2019 Category: Neuroscience Source Type: research
Publisher's Note
Publication date: July 2019Source: Progress in Neurobiology, Volume 178Author(s): (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - June 15, 2019 Category: Neuroscience Source Type: research
Regulation of signaling proteins in the brain by light
Publication date: Available online 11 June 2019Source: Progress in NeurobiologyAuthor(s): Raphael LamprechtAbstractIn order to study the role of signaling proteins, such as kinases and GTPases, in brain functions it is necessary to control their activity at the appropriate spatiotemporal resolution and to examine the cellular and behavioral effects of such changes in activity. Reduced spatiotemporal resolution in the regulation of these proteins activity will impede the ability to understand the proteins normal functions as longer modification of their activity in non-normal locations could lead to effects different from t...
Source: Progress in Neurobiology - June 12, 2019 Category: Neuroscience Source Type: research
Publisher's Note
Publication date: Available online 29 May 2019Source: Progress in NeurobiologyAuthor(s): (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - May 30, 2019 Category: Neuroscience Source Type: research
HIV-1 infection alters energy metabolism in the brain: Contributions to HIV-associated neurocognitive disorders
Publication date: Available online 18 May 2019Source: Progress in NeurobiologyAuthor(s): Bianca Cotto, Kalimuthusamy Natarajanseenivasan, Dianne LangfordAbstractThe brain is particularly sensitive to changes in energy supply. Defects in glucose utilization and mitochondrial dysfunction are hallmarks of nearly all neurodegenerative diseases and are also associated with the cognitive decline that occurs as the brain ages. Chronic neuroinflammation driven by glial activation is commonly implicated as a contributing factor to neurodegeneration and cognitive impairment. Human immunodeficiency virus-1 (HIV-1) disrupts normal bra...
Source: Progress in Neurobiology - May 26, 2019 Category: Neuroscience Source Type: research
