HIV-1 infection alters energy metabolism in the brain:contributions to HIV-associated neurocognitive disorders
Publication date: Available online 18 May 2019Source: Progress in NeurobiologyAuthor(s): Bianca Cotto, Kalimuthusamy Natarajaseenivasan, Dianne LangfordAbstractThe brain is particularly sensitive to changes in energy supply. Defects in glucose utilization and mitochondrial dysfunction are hallmarks of nearly all neurodegenerative diseases and are also associated with the cognitive decline that occurs as the brain ages. Chronic neuroinflammation driven by glial activation is commonly implicated as a contributing factor to neurodegeneration and cognitive impairment. Human immunodeficiency virus-1 (HIV-1) disrupts normal brai...
Source: Progress in Neurobiology - May 18, 2019 Category: Neuroscience Source Type: research
Angioneurins – Key regulators of blood–brain barrier integrity during hypoxic and ischemic brain injury
Publication date: Available online 7 April 2019Source: Progress in NeurobiologyAuthor(s): Reiner Kunze, Hugo H. MartiAbstractThe loss of blood–brain barrier (BBB) integrity leading to vasogenic edema and brain swelling is a common feature of hypoxic/ischemic brain diseases such as stroke, but is also central to the etiology of other CNS disorders. In the past decades, numerous proteins, belonging to the family of angioneurins, have gained increasing attention as potential therapeutic targets for ischemic stroke, but also other CNS diseases attributed to BBB dysfunction. Angioneurins encompass mediators that affect both n...
Source: Progress in Neurobiology - May 15, 2019 Category: Neuroscience Source Type: research
Microglia: Lifelong Patrolling Immune Cells of the Brain
Publication date: Available online 7 May 2019Source: Progress in NeurobiologyAuthor(s): Ukpong B. Eyo, Long-Jun WuAbstractMicroglial cells are the predominant parenchymal immune cell of the brain. Recent evidence suggests that like peripheral immune cells, microglia patrol the brain in health and disease. Reviewing these data, we first examine the evidence that microglia invade the brain mesenchyme early in embryonic development, establish residence therein, proliferate and subsequently maintain their numbers throughout life. We, then, summarize established and novel evidence for microglial process surveillance in the heal...
Source: Progress in Neurobiology - May 9, 2019 Category: Neuroscience Source Type: research
A review of neurobiological factors underlying the selective enhancement of memory at encoding, consolidation, and retrieval
Publication date: Available online 2 May 2019Source: Progress in NeurobiologyAuthor(s): Rebecca Crowley, Daniel Bendor, Amir-Homayoun JavadiAbstractHow is the strength of a memory determined? This review discusses three main factors that contribute to memory enhancement - 1) emotion, 2) targeted memory reactivation, and 3) neural reinstatement. Whilst the mechanisms through which memories become enhanced vary, this review demonstrates that activation of the basolateral amygdala and hippocampal formation are crucial for facilitating encoding, consolidation, and retrieval. Here we suggest methodological factors to consider i...
Source: Progress in Neurobiology - May 3, 2019 Category: Neuroscience Source Type: research
Editorial Board
Publication date: June 2019Source: Progress in Neurobiology, Volume 177Author(s): (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - April 27, 2019 Category: Neuroscience Source Type: research
8-Oxoguanine accumulation in aged female brain impairs neurogenesis in the dentate gyrus and major island of Calleja, causing sexually dimorphic phenotypes
Publication date: Available online 23 April 2019Source: Progress in NeurobiologyAuthor(s): Naoki Haruyama, Kunihiko Sakumi, Atsuhisa Katogi, Daisuke Tsuchimoto, Gabriele De Luca, Margherita Bignami, Yusaku NakabeppuAbstractIn mammals, including humans, MTH1 with 8-oxo-dGTPase and OGG1 with 8-oxoguanine DNA glycosylase minimize 8-oxoguanine accumulation in genomic DNA. We investigated age-related alterations in behavior, 8-oxoguanine levels, and neurogenesis in the brains of Mth1/Ogg1-double knockout (TO-DKO), Ogg1-knockout, and human MTH1-transgenic (hMTH1-Tg) mice. Spontaneous locomotor activity was significantly decrease...
Source: Progress in Neurobiology - April 24, 2019 Category: Neuroscience Source Type: research
Editorial Board
Publication date: May 2019Source: Progress in Neurobiology, Volume 176Author(s): (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - April 11, 2019 Category: Neuroscience Source Type: research
Angioneurins–key regulators of blood-brain barrier integrity during hypoxic and ischemic brain injury
Publication date: Available online 7 April 2019Source: Progress in NeurobiologyAuthor(s): Reiner Kunze, Hugo H. MartiAbstractThe loss of blood-brain barrier (BBB) integrity leading to vasogenic edema and brain swelling is a common feature of hypoxic/ischemic brain diseases such as stroke, but is also central to the etiology of other CNS disorders. In the past decades, numerous proteins, belonging to the family of angioneurins, have gained increasing attention as potential therapeutic targets for ischemic stroke, but also other CNS diseases attributed to BBB dysfunction. Angioneurins encompass mediators that affect both neu...
Source: Progress in Neurobiology - April 8, 2019 Category: Neuroscience Source Type: research
Are periaqueductal gray and dorsal raphe the foundation of appetitive and aversive control? A comprehensive review
Publication date: Available online 17 February 2019Source: Progress in NeurobiologyAuthor(s): Carlos Silva, Neil McNaughtonAbstractMany see the periaqueductal gray (PAG) as a region responsible for the downstream control of defensive reactions. Here we provide a detailed review of anatomical and functional data on the different parts of the PAG together with the dorsal raphe, which completes the circle of periaqueductal nuclei. Based on anatomical features, we propose a new subdivision of the periaqueductal gray that accounts for the distinct characteristics of the area. We provide a comprehensive functional view of the pe...
Source: Progress in Neurobiology - April 5, 2019 Category: Neuroscience Source Type: research
Microglia: brain cells on the move
Publication date: Available online 4 April 2019Source: Progress in NeurobiologyAuthor(s): Sophie Marie-Thérèse Smolders, Sofie Kessels, Tim Vangansewinkel, Jean-Michel Rigo, Pascal Legendre, Bert BrôneAbstractIn the last decade, tremendous progress has been made in understanding the biology of microglia - i.e. The fascinating immigrated resident immune cell population of the central nervous system (CNS). Recent literature reviews have largely dealt with the plentiful functions of microglia in CNS homeostasis, development and pathology, and the influences of sex and the microbiome. In this review, the intriguing aspect o...
Source: Progress in Neurobiology - April 5, 2019 Category: Neuroscience Source Type: research
Progress in neuromodulation of the brain: A role for magnetic nanoparticles?
Publication date: Available online 13 March 2019Source: Progress in NeurobiologyAuthor(s): Milaine Roet, Sarah-Anna Hescham, Ali Jahanshahi, Bart P.F. Rutten, Polina O. Anikeeva, Yasin TemelAbstractThe field of neuromodulation is developing rapidly. Current techniques, however, are still limited as they i) either depend on permanent implants, ii) require invasive procedures, iii) are not cell-type specific, iv) involve slow pharmacokinetics or v) have a restricted penetration depth making it difficult to stimulate regions deep within the brain. Refinements into the different fields of neuromodulation are thus needed. In th...
Source: Progress in Neurobiology - March 27, 2019 Category: Neuroscience Source Type: research
Role and Mechanisms of Cytokines in the Secondary Brain Injury After Intracerebral Hemorrhage
Publication date: Available online 25 March 2019Source: Progress in NeurobiologyAuthor(s): Huimin Zhu, Zhiqiang Wang, Jixu Yu, Xiuli Yang, Feng He, Zhenchuan Liu, Fengyuan Che, Xuemei Chen, Honglei Ren, Michael Hong, Jian WangAbstractIntracerebral hemorrhage (ICH) is a common and severe cerebrovascular disease that has high mortality. Few survivors achieve self-care. Currently, patients receive only symptomatic treatment for ICH and benefit poorly from this regimen. Inflammatory cytokines are important participants in secondary injury after ICH. Increases in proinflammatory cytokines may aggravate the tissue injury, wherea...
Source: Progress in Neurobiology - March 26, 2019 Category: Neuroscience Source Type: research
Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior
Publication date: Available online 21 March 2019Source: Progress in NeurobiologyAuthor(s): Dick R. Nässel, Meet ZandawalaAbstractThis review focuses on neuropeptides and peptide hormones, the largest and most diverse class of neuroactive substances, known in Drosophila and other animals to play roles in almost all aspects of daily life, as well as in developmental processes. We provide an update on novel neuropeptides and receptors identified in the last decade, and highlight progress in analysis of neuropeptide signaling in Drosophila. Especially exciting is the huge amount of work published on novel functions of neurope...
Source: Progress in Neurobiology - March 23, 2019 Category: Neuroscience Source Type: research
Progress in neuromodulation of the brain; a role for magnetic nanoparticles?
Publication date: Available online 13 March 2019Source: Progress in NeurobiologyAuthor(s): Milaine Roet, Sarah-Anna Hescham, Ali Jahanshahi, Bart P.F. Rutten, Polina O. Anikeeva, Yasin TemelAbstractThe field of neuromodulation is developing rapidly. Current techniques, however, are still limited as they i) either depend on permanent implants, ii) require invasive procedures, iii) are not cell-type specific, iv) involve slow pharmacokinetics or v) have a restricted penetration depth making it difficult to stimulate regions deep within the brain. Refinements into the different fields of neuromodulation are thus needed. In th...
Source: Progress in Neurobiology - March 14, 2019 Category: Neuroscience Source Type: research
Effects of estrogens and androgens on mitochondria under normal and pathological conditions
Publication date: Available online 7 March 2019Source: Progress in NeurobiologyAuthor(s): Mohammad Mohajeri, Cynthia Martín-Jiménez, George E. Barreto, Amirhossein SahebkarAbstractSeveral lines of evidence have suggested that mitochondrial dysfunction plays a key role in neurodegeneration. The mitochondrial function is a potential target for steroid hormones, which could exert protective activities in the brain and other tissues. The decrease of some sex steroids with aging has been associated with deleterious effects on brain function and progression to neurodegenerative diseases. Recent in vitro and in vivo evidence pr...
Source: Progress in Neurobiology - March 8, 2019 Category: Neuroscience Source Type: research
