Editorial Board
Publication date: February 2020Source: Progress in Neurobiology, Volume 185Author(s): (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - January 23, 2020 Category: Neuroscience Source Type: research
Corrigendum to “Dystonia and dopamine: From phenomenology to pathophysiology” [Prog. Neurobiol. 182 (November) (2019), 101678, 18]
Publication date: Available online 9 January 2020Source: Progress in NeurobiologyAuthor(s): Bastien Ribot, Jérome Aupy, Marie Vidailhet, Joachim Mazère, Antonio Pisani, Erwan Bezard, Dominique Guehl, Pierre Burbaud (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - January 10, 2020 Category: Neuroscience Source Type: research
Role of Circular RNAs in Brain Development and CNS Diseases
Publication date: Available online 10 January 2020Source: Progress in NeurobiologyAuthor(s): Suresh L. Mehta, Robert J. Dempsey, Raghu VemugantiAbstractIn mammals, many classes of noncoding RNAs (ncRNAs) are expressed at a much higher level in the brain than in other organs. Recent studies have identified a new class of ncRNAs called circular RNAs (circRNAs), which are produced by back-splicing and fusion of either exons, introns, or both exon-intron into covalently closed loops. The circRNAs are also highly enriched in the brain and increase continuously from the embryonic to the adult stage. Although the functional signi...
Source: Progress in Neurobiology - January 10, 2020 Category: Neuroscience Source Type: research
Editorial Board
Publication date: January 2020Source: Progress in Neurobiology, Volume 184Author(s): (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - December 28, 2019 Category: Neuroscience Source Type: research
Regional iron distribution and soluble ferroprotein profiles in the healthy human brain
This study is the first of its kind in human brain tissue, providing a valuable resource and new insight for iron biologists and neuroscientists, alike.Graphical abstract (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - December 22, 2019 Category: Neuroscience Source Type: research
Reelin reverts biochemical, physiological and cognitive alterations in mouse models of Tauopathy
Publication date: Available online 20 December 2019Source: Progress in NeurobiologyAuthor(s): Daniela Rossi, Agnès Gruart, Gerardo Contreras-Murillo, Ashraf Muhaisen, Jesús Ávila, José María Delgado-García, Lluís Pujadas, Eduardo SorianoAbstractReelin is an extracellular protein crucial for adult brain plasticity. Moreover, Reelin is protective against amyloid-β (Aβ) pathology in Alzheimer’s Disease (AD), reducing plaque deposition, synaptic loss and cognitive decline. Given that Tau protein plays a key role in AD pathogenesis, and that the Reelin pathway modulates Tau phosphorylation, here we explored the invol...
Source: Progress in Neurobiology - December 22, 2019 Category: Neuroscience Source Type: research
A multi-faceted genotoxic network of alpha-synuclein in the nucleus and mitochondria of dopaminergic neurons in Parkinson’s disease: Emerging concepts and challenges
Publication date: Available online 18 December 2019Source: Progress in NeurobiologyAuthor(s): Velmarini Vasquez, Joy Mitra, Haibo Wang, Pavana M. Hegde, K.S. Rao, Muralidhar L. HegdeAbstractα-Synuclein is a hallmark amyloidogenic protein component of the Lewy bodies (LBs) that are found in dopaminergic neurons affected by Parkinson’s disease (PD). Despite an enormous increase in emerging knowledge, the mechanism(s) of α-synuclein neurobiology and crosstalk among pathological events that are critical for PD progression remains enigmatic, creating a roadblock for effective intervention strategies. One confounding questio...
Source: Progress in Neurobiology - December 19, 2019 Category: Neuroscience Source Type: research
Deciphering midbrain mechanisms underlying prepulse inhibition of startle
Publication date: Available online 19 December 2019Source: Progress in NeurobiologyAuthor(s): Niveen Fulcher, Erin Azzopardi, Cleusa De Oliveira, Roger Hudson, Ashley L. Schormans, Tariq Zaman, Brian L. Allman, Steven R. Laviolette, Susanne SchmidAbstractPrepulse inhibition (PPI) is an operational measure of sensorimotor gating. Deficits of PPI are a hallmark of schizophrenia and associated with several other psychiatric illnesses such as e.g. autism spectrum disorder, yet the mechanisms underlying PPI are still not fully understood. There is growing evidence contradicting the long-standing hypothesis that PPI is mediated ...
Source: Progress in Neurobiology - December 19, 2019 Category: Neuroscience Source Type: research
Conserved and divergent expression dynamics during early patterning of the telencephalon in mouse and chick embryos
Publication date: Available online 14 December 2019Source: Progress in NeurobiologyAuthor(s): Vijaykumar Yogesh Muley, Carlos Javier López-Victorio, Jorge Tonatiuh Ayala-Sumuano, Adriana González-Gallardo, Leopoldo González-Santos, Carlos Lozano-Flores, Gregory Wray, Maribel Hernández, Alfredo Varela-EchavarríaAbstractThe mammalian and the avian telencephalon are nearly indistinguishable at early embryonic vesicle stages but differ substantially in form and function at their adult stage. We sequenced and analyzed RNA populations present in mouse and chick during the early stages of embryonic telencephalon to understan...
Source: Progress in Neurobiology - December 14, 2019 Category: Neuroscience Source Type: research
Identifying neuronal correlates of dying and resuscitation in a model of reversible brain anoxia
Publication date: Available online 10 December 2019Source: Progress in NeurobiologyAuthor(s): Adrien E. Schramm, Antoine Carton-Leclercq, Shana Diallo, Vincent Navarro, Mario Chavez, Séverine Mahon, Stéphane CharpierAbstractWe developed a new rodent model of reversible brain anoxia and performed continuous electrocorticographic (ECoG) and intracellular recordings of neocortical neurons to identify in real-time the cellular and network dynamics that successively emerge throughout the dying-to-recovery process. Along with a global decrease in ECoG amplitude, deprivation of oxygen supply resulted in an early surge of beta-g...
Source: Progress in Neurobiology - December 11, 2019 Category: Neuroscience Source Type: research
Circulating microRNAs as potential biomarkers for psychiatric and neurodegenerative disorders
Publication date: Available online 7 December 2019Source: Progress in NeurobiologyAuthor(s): M.M.J. van den Berg, J. Krauskopf, J.G. Ramaekers, J.C.S. Kleinjans, J. Prickaerts, J.J. BriedéAbstractCirculating microRNAs (cimiRNAs) are a class of non-encoding RNAs found in bodily fluids such as blood, cerebrospinal fluid (CSF) and tears. CimiRNAs have been implicated as promising biomarkers for central nervous system (CNS) disorders because they are actively secreted as messengers and are profoundly involved in fine-tuning of developmental and differentiation processes. Furthermore, they are attractive biomarkers because the...
Source: Progress in Neurobiology - December 7, 2019 Category: Neuroscience Source Type: research
Editorial Board
Publication date: December 2019Source: Progress in Neurobiology, Volume 183Author(s): (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - November 27, 2019 Category: Neuroscience Source Type: research
Dissecting beta-state changes during timed movement preparation in Parkinson’s disease
Publication date: Available online 25 November 2019Source: Progress in NeurobiologyAuthor(s): Simone G. Heideman, Andrew J. Quinn, Mark W. Woolrich, Freek van Ede, Anna C. NobreAbstractAn emerging perspective describes beta-band (15-28 Hz) activity as consisting of short-lived high-amplitude events that only appear sustained in conventional measures of trial-average power. This has important implications for characterising abnormalities observed in beta-band activity in disorders like Parkinson’s disease. Measuring parameters associated with beta-event dynamics may yield more sensitive measures, provide more selective ...
Source: Progress in Neurobiology - November 26, 2019 Category: Neuroscience Source Type: research
Traumatic Brain Injury Triggers APP and Tau Cleavage by Delta-secretase, Mediating Alzheimer’s Disease Pathology
Publication date: Available online 25 November 2019Source: Progress in NeurobiologyAuthor(s): Zhourui Wu, Zhi-Hao Wang, Xia Liu, Zhentao Zhang, Shan Ping Yu, C. Dirk Keene, Liming Cheng, Keqiang YeAbstractTraumatic brain injury (TBI) is associated in some studies with clinical dementia, and neuropathological features, including amyloid plaque deposition and Tau neurofibrillary degeneration commonly identified in Alzheimer’s disease (AD). However, the molecular mechanisms linking TBI to AD remain unclear. Here we show that TBI activates transcription factor CCAAT/Enhancer Binding Protein Beta (C/EBPβ), increasing delta-s...
Source: Progress in Neurobiology - November 26, 2019 Category: Neuroscience Source Type: research
N-acetylaspartylglutamate (NAAG) and Glutamate Carboxypeptidase II: An abundant peptide neurotransmitter-enzyme system with multiple clinical applications
Publication date: Available online 12 November 2019Source: Progress in NeurobiologyAuthor(s): Joseph H. Neale, Tatsuo YamamotoAbstractN-Acetylaspartylglutamate (NAAG) is the third most prevalent neurotransmitter in the mammalian nervous system, yet its therapeutic potential is only now being fully recognized. Drugs that inhibit the inactivation of NAAG by glutamate carboxypeptidase II (GCPII) increase its extracellular concentration and its activation of its receptor, mGluR3. These drugs warrant attention, as they are effective in animal models of several clinical disorders including stroke, traumatic brain injury and schi...
Source: Progress in Neurobiology - November 13, 2019 Category: Neuroscience Source Type: research
