Comprehensive review of mechanisms of pathogenesis involved in Alzheimer’s disease and potential therapeutic strategies
Publication date: Available online 30 December 2018Source: Progress in NeurobiologyAuthor(s): Piyoosh Sharma, Pavan Srivastava, Ankit Seth, Prabhash Nath Tripathi, Anupam G. Banerjee, Sushant K. ShrivastavaAbstractAD is a progressive neurodegenerative disorder and a leading cause of dementia in an aging population worldwide. The enormous challenge which AD possesses to global healthcare makes it as urgent as ever for the researchers to develop innovative treatment strategies to fight this disease. An in-depth analysis of the extensive available data associated with the AD is needed for a more comprehensive understanding of...
Source: Progress in Neurobiology - December 30, 2018 Category: Neuroscience Source Type: research
Pivotal role of carnosine in the modulation of brain cells activity: multimodal mechanism of action and therapeutic potential in neurodegenerative disorders
Publication date: Available online 26 December 2018Source: Progress in NeurobiologyAuthor(s): Giuseppe Caruso, Filippo Caraci, Renaud B. JolivetAbstractCarnosine (β-alanyl-L-histidine), a dipeptide, is an endogenous antioxidant widely distributed in excitable tissues like muscles and the brain. Although discovered more than a hundred years ago and having been extensively studied in the periphery, the role of carnosine in the brain remains mysterious. Carnosinemia, a rare metabolic disorder with increased levels of carnosine in urine and low levels or absence of carnosinase in the blood, is associated with severe neurologi...
Source: Progress in Neurobiology - December 27, 2018 Category: Neuroscience Source Type: research
Lateral parietal cortex in the generation of behavior: implications for apathy
Publication date: Available online 24 December 2018Source: Progress in NeurobiologyAuthor(s): S. Tumati, S. Martens, B.M. de Jong, A. AlemanAbstractA reduction in goal-directed behavior, or apathy, occurs in neurological and psychiatric disorders, while its neural substrates remain unclear. Deficits in circuits connecting the prefrontal cortex to subcortical regions are considered to underlie apathy. Although apathy is empirically associated with widespread changes in these regions, studies across disorders also link apathy with the lateral parietal cortex. Such variety in regional involvement is consistent with the establ...
Source: Progress in Neurobiology - December 25, 2018 Category: Neuroscience Source Type: research
Editorial Board
Publication date: January 2019Source: Progress in Neurobiology, Volume 172Author(s): (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - December 25, 2018 Category: Neuroscience Source Type: research
Brain changes in a maternal Immune activation model of neurodevelopmental brain disorders
Publication date: Available online 24 December 2018Source: Progress in NeurobiologyAuthor(s): Lara Bergdolt, Anna DunaevskyAbstractThe developing brain is sensitive to a variety of insults. Epidemiological studies have identified prenatal exposure to infection as a risk factor for a range of neurological disorders, including autism spectrum disorder and schizophrenia. Animal models corroborate this association and have been used to probe the contribution of gene-environment interactions to the etiology of neurodevelopmental disorders. Here we review the behavior and brain phenotypes that have been characterized in MIA offs...
Source: Progress in Neurobiology - December 24, 2018 Category: Neuroscience Source Type: research
