Editorial Board
Publication date: April 2019Source: Progress in Neurobiology, Volume 175Author(s): (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - February 27, 2019 Category: Neuroscience Source Type: research
Are periaqueductal grey and dorsal raphe the foundation of appetitive and aversive control? A comprehensive review
Publication date: Available online 17 February 2019Source: Progress in NeurobiologyAuthor(s): Carlos Silva, Neil McNaughtonAbstractMany see the periaqueductal grey (PAG) as a region responsible for the downstream control of defensive reactions. Here we provide a detailed review of anatomical and functional data on the different parts of the PAG together with the dorsal raphe, which completes the circle of periaqueductal nuclei. Based on anatomical features, we propose a new subdivision of the periaqueductal grey that accounts for the distinct characteristics of the area. We provide a comprehensive functional view of the pe...
Source: Progress in Neurobiology - February 18, 2019 Category: Neuroscience Source Type: research
Nitroglycerin as a comparative experimental model of migraine pain: from animal to human and back
Publication date: Available online 13 February 2019Source: Progress in NeurobiologyAuthor(s): Chiara Demartini, Rosaria Greco, Anna Maria Zanaboni, Grazia Sances, Roberto De Icco, David Borsook, Cristina TassorelliAbstractMigraine is a disease for which there is still no defined pathophysiological etiology and few translational models. The organic nitrate nitroglycerin has been in use as an experimental model of migraine in both human and animal studies for several years. The drug produces a number of effects within the head, that includes blood vessels, nerves and brain areas that may produce a response similar to a migra...
Source: Progress in Neurobiology - February 14, 2019 Category: Neuroscience Source Type: research
Editorial Board
Publication date: March 2019Source: Progress in Neurobiology, Volume 174Author(s): (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - February 12, 2019 Category: Neuroscience Source Type: research
The Roles of Supervised Machine Learning in Systems Neuroscience
We describe four primary roles of ML within neuroscience: 1) creating solutions to engineering problems, 2) identifying predictive variables, 3) setting benchmarks for simple models of the brain, and 4) serving itself as a model for the brain. The breadth and ease of its applicability suggests that machine learning should be in the toolbox of most systems neuroscientists. (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - February 8, 2019 Category: Neuroscience Source Type: research
Sex Differences in Depression: Insights from Clinical and Preclinical Studies
Publication date: Available online 2 February 2019Source: Progress in NeurobiologyAuthor(s): Rand S. Eid, Aarthi R. Gobinath, Liisa A.M. GaleaAbstractDepression represents a global mental health concern, and disproportionally affects women as they are twice more likely to be diagnosed than men. In this review, we provide a summary of evidence to support the notion that differences in depression between men and women span multiple facets of the disease, including epidemiology, symptomology, treatment, and pathophysiology. Through a lens of biological sex, we overview depression-related transcriptional patterns, changes in n...
Source: Progress in Neurobiology - February 3, 2019 Category: Neuroscience Source Type: research
Action Perception and Motor Imagery: Mental Practice of Action
Publication date: Available online 31 January 2019Source: Progress in NeurobiologyAuthor(s): Helen E. Savaki, Vassilis RaosAbstractMotor cognition is related to the planning and generation of actions as well as to the recognition and imagination of motor acts. Recently, there is evidence that the motor system participates not only in overt actions but also in mental processes supporting covert actions. Within this framework, we have investigated the cortical areas engaged in execution, observation, and imagination of the same action, by the use of the high resolution quantitative 14C-deoxyglucose method in monkeys and by f...
Source: Progress in Neurobiology - February 1, 2019 Category: Neuroscience Source Type: research
New windows into the brain: Central nervous system-derived extracellular vesicles in blood
Publication date: Available online 25 January 2019Source: Progress in NeurobiologyAuthor(s): Min Shi, Lifu Sheng, Tessandra Stewart, Cyrus P. Zabetian, Jing ZhangAbstractExtracellular vesicles (EVs), including exosomes and (shedding) microvesicles, are released by nearly all cell types and carry a cargo of proteins and nucleic acids that varies by the cell of origin. They are thought to play critical roles in normal central nervous system (CNS) function and neurological disorders. A recently revealed key characteristic of EVs is that they may travel between the CNS and peripheral circulation. This property has led to inten...
Source: Progress in Neurobiology - January 25, 2019 Category: Neuroscience Source Type: research
Precision in the Development of Neocortical Architecture: from Progenitors to Cortical Networks
Publication date: Available online 21 January 2019Source: Progress in NeurobiologyAuthor(s): Ryan J. Kast, Pat LevittAbstractOf all brain regions, the 6-layered neocortex has undergone the most dramatic changes in size and complexity during mammalian brain evolution. These changes, occurring in the context of a conserved set of organizational features that emerge through stereotypical developmental processes, are considered responsible for the cognitive capacities and sensory specializations represented within the mammalian clade. The modern experimental era of developmental neurobiology, spanning 6 decades, has deciphered...
Source: Progress in Neurobiology - January 22, 2019 Category: Neuroscience Source Type: research
The circuit architecture of cortical multisensory processing: distinct functions jointly operating within a common anatomical network
Publication date: Available online 21 January 2019Source: Progress in NeurobiologyAuthor(s): Guido T. Meijer, Paul E.C. Mertens, Cyriel M.A. Pennartz, Umberto Olcese, Carien S. LansinkAbstractOur perceptual systems continuously process sensory inputs from different modalities and organize these streams of information such that our subjective representation of the outside world is a unified experience. By doing so, they also enable further cognitive processing and behavioral action. While cortical multisensory processing has been extensively investigated in terms of psychophysics and mesoscale neural correlates, an in depth...
Source: Progress in Neurobiology - January 22, 2019 Category: Neuroscience Source Type: research
Editorial Board
Publication date: February 2019Source: Progress in Neurobiology, Volume 173Author(s): (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - January 18, 2019 Category: Neuroscience Source Type: research
Chronotherapies for Parkinson’s Disease
Publication date: Available online 15 January 2019Source: Progress in NeurobiologyAuthor(s): Karim Fifel, Aleksandar VidenovicAbstractParkinson’s disease (PD) is the second-most common progressive neurodegenerative disorder. Although the clinical diagnosis of PD is still based on its cardinal motor dysfunctions, several non-motor symptoms (NMS) have been established as integral part of the disease. Unlike motor disorders, development of therapies against NMS are still challenging and remain a critical unmet clinical need. During the last decade, several studies have characterised the molecular, physiological and behaviou...
Source: Progress in Neurobiology - January 16, 2019 Category: Neuroscience Source Type: research
Adult neurogenesis promotes balance recovery after vestibular loss
Publication date: Available online 15 January 2019Source: Progress in NeurobiologyAuthor(s): Brahim Tighilet, Christian ChabbertAbstractA phenomenon called vestibular compensation occurs after peripheral vestibular loss. This process involves a mosaic of profound structural rearrangements within the vestibular nuclei. Among them, adult reactive neurogenesis is perhaps the most unexpected, as it occurs in a brain area that was never reported as neurogenic before. Both the survival and functionality of this newly generated neuronal network depend on its integration into preexisting networks in the deafferented structure. Far...
Source: Progress in Neurobiology - January 16, 2019 Category: Neuroscience Source Type: research
It’s all about tau
Publication date: Available online 31 December 2018Source: Progress in NeurobiologyAuthor(s): Cheril Tapia-Rojas, Fabian Cabezas-Opazo, Carol A. Deaton, Erick H. Vergara, Gail V.W. Johnson, Rodrigo A. QuintanillaAbstractTau is a protein that is highly enriched in neurons and was originally defined by its ability to bind and stabilize microtubules. However, it is now becoming evident that the functions of tau extend beyond its ability to modulate microtubule dynamics. Tau plays a role in mediating axonal transport, synaptic structure and function, and neuronal signaling pathways. Although tau plays important physiological r...
Source: Progress in Neurobiology - January 1, 2019 Category: Neuroscience Source Type: research
Transcriptional and epigenetic mechanisms underlying astrocyte identity
Publication date: Available online 29 December 2018Source: Progress in NeurobiologyAuthor(s): Maria Angeliki S. Pavlou, Luc Grandbarbe, Noel J. Buckley, Simone P. Niclou, Alessandro MichelucciAbstractAstrocytes play a significant role in coordinating neural development and provide critical support for the function of the CNS. They possess important adaptation capacities that range from their transition towards reactive astrocytes to their ability to undergo reprogramming, thereby revealing their potential to retain latent features of neural progenitor cells. We propose that the mechanisms underlying reactive astrogliosis o...
Source: Progress in Neurobiology - December 30, 2018 Category: Neuroscience Source Type: research
