Microglia, neurodegeneration and loss of neuroendocrine control
Publication date: Available online 9 November 2019Source: Progress in NeurobiologyAuthor(s): Julie A. Chowen, Luis M. Garcia-SeguraAbstractMicroglia, the primary regulators of inflammatory responses in the brain, suffer deterioration during aging culminating in their inability to generate adequate adaptive responses to maintain physiological homeostasis in brain tissue. Microglia affect the function of other glial cells and neurons, including those involved in the hypothalamic control of body homeostasis. Microglial dysfunction with aging in cognitive areas such as the hippocampus is known to associate with cognitive decli...
Source: Progress in Neurobiology - November 9, 2019 Category: Neuroscience Source Type: research
Nerve growth factor against PTSD symptoms: preventing the impaired hippocampal cytoarchitectures
Publication date: Available online 5 November 2019Source: Progress in NeurobiologyAuthor(s): Da-Yun Feng, Bao-Lin Guo, Gao-Hua Liu, Ke Xu, Jing Yang, Kai Tao, Jing Huang, Li-Ying Wang, Wen Wang, Sheng-Xi WuAbstractAlthough exogenous nerve growth factor demonstrated great potential for post-traumatic stress disorder (PTSD) treatment, its therapeutic effect and underlying cytological mechanism were not fully elucidated so far. We employed a controlled, prospectively designed modified single prolonged stress mice model to investigate the role of exogenous nerve growth factor on the modified single prolonged stress induced PTS...
Source: Progress in Neurobiology - November 6, 2019 Category: Neuroscience Source Type: research
Can the emerging field of immunometabolism provide insights into neuroinflammation?
Publication date: Available online 6 November 2019Source: Progress in NeurobiologyAuthor(s): Marina A. LynchAbstractIn the past few years it has become increasingly clear that an understanding of the interaction between metabolism and immune function can provide an insight into cellular responses to challenges. Significant progress has been made in terms of how macrophages are metabolically re-programmed in response to inflammatory stimuli but, to date, little emphasis has been placed on evaluating equivalent changes in microglia. The need to make progress is driven by the fact that, while microglial activation and the cel...
Source: Progress in Neurobiology - November 6, 2019 Category: Neuroscience Source Type: research
Structure Learning and the Posterior Parietal Cortex
Publication date: Available online 24 October 2019Source: Progress in NeurobiologyAuthor(s): Christopher Summerfield, Fabrice Luyckx, Hannah SheahanAbstractWe propose a theory of structure learning in the primate brain. We argue that the parietal cortex is critical for learning about relations among the objects and categories that populate a visual scene. We suggest that current deep learning models exhibit poor global scene understanding because they fail to perform the relational inferences that occur in the primate dorsal stream. We review studies of neural coding in primate posterior parietal cortex (PPC), drawing the ...
Source: Progress in Neurobiology - October 25, 2019 Category: Neuroscience Source Type: research
Neurofilament-Lysosomal Genetic Intersections in the Cortical Network of Stuttering
In this study we identified the large-scale cortical network that characterizes stuttering using functional connectivity MRI and graph theory. We performed a spatial similarity analysis that examines whether the topology of the stuttering cortical network intersects with genetic expression levels of previously reported genes for stuttering from the protein-coding transcriptome data of the Allen Human Brain Atlas. We found that GNPTG – a gene involved in the mannose-6-phosphate lysosomal targeting pathways – was significantly co-localized with the stuttering cortical network. An enrichment analysis demonstrated that the...
Source: Progress in Neurobiology - October 25, 2019 Category: Neuroscience Source Type: research
Editorial Board
Publication date: November 2019Source: Progress in Neurobiology, Volume 182Author(s): (Source: Progress in Neurobiology)
Source: Progress in Neurobiology - October 22, 2019 Category: Neuroscience Source Type: research
Repeat-associated non-AUG (RAN) translation mechanisms are running into focus for GGGGCC-repeat associated ALS/FTD
Publication date: Available online 21 September 2019Source: Progress in NeurobiologyAuthor(s): Lindsey D. Goodman, Nancy M. BoniniAbstractMany human diseases are associated with the expansion of repeat sequences within the genes. It has become clear that expressed disease transcripts bearing such long repeats can undergo translation, even in the absence of a canonical AUG start codon. Termed “RAN translation” for repeat associated non-AUG translation, this process is becoming increasingly prominent as a contributor to these disorders. Here we discuss mechanisms and variables that impact translation of the repeat sequen...
Source: Progress in Neurobiology - October 10, 2019 Category: Neuroscience Source Type: research
Prognostic plasma protein panel for Aβ deposition in the brain in Alzheimer’s disease
This study used 107 individuals who were cognitively normal (CN), 107 patients with mild cognitive impairment (MCI), and 40 AD patients with Pittsburg compound B positron emission tomography (PiB-PET) amyloid imaging data available. We found five plasma biomarker candidates via mass spectrometry (MS) based-proteomic analysis and validated these proteins using enzyme-linked immunosorbent assay (ELISA). Our integrated models were highly predictive of brain amyloid deposition, exhibiting 0.871 accuracy with 79% sensitivity and 84% specificity overall, and 0.836 accuracy with 68% sensitivity and 90% specificity in patients wit...
Source: Progress in Neurobiology - October 10, 2019 Category: Neuroscience Source Type: research
Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer’s disease from a ferroptosis perspective
Publication date: Available online 8 October 2019Source: Progress in NeurobiologyAuthor(s): Paul J. Derry, Muralidhar L. Hegde, George R. Jackson, Rakez Kayed, James M. Tour, Thomas A. Kent, Ah-Lim TsaAbstractThe complexity of Alzheimer’s disease (AD) complicates the search for effective treatments. While the key roles of pathologically modified proteins has occupied a central role in hypotheses of the pathophysiology, less attention has been paid to the potential role for transition metals overload, subsequent oxidative stress, and tissue injury. The association of transition metals, the major focus heretofore iron and ...
Source: Progress in Neurobiology - October 9, 2019 Category: Neuroscience Source Type: research
Metabolomics Reveals Highly Regional Specificity of Cerebral Sexual Dimorphism in Mice
Publication date: Available online 23 September 2019Source: Progress in NeurobiologyAuthor(s): Floris Chabrun, Xavier Dieu, Guillaume Rousseau, Stéphanie Chupin, Franck Letournel, Vincent Procaccio, Dominique Bonneau, Guy Lenaers, Gilles Simard, Delphine Mirebeau-Prunier, Juan Manuel Chao de la Barca, Pascal ReynierAbstractThe development of personalized medicine according to gender calls for the integration of sexual dimorphism in pre-clinical models of diseases. Although sexual dimorphism in the brain of the mouse has been the subject of several behavioral, neuroimaging and experimental studies, very few have characteri...
Source: Progress in Neurobiology - September 24, 2019 Category: Neuroscience Source Type: research
Connectional gradients underlie functional transitions in monkey pre-supplementary motor area
Publication date: Available online 23 September 2019Source: Progress in NeurobiologyAuthor(s): Davide Albertini, Marzio Gerbella, Marco Lanzilotto, Alessandro Livi, Monica Maranesi, Carolina Giulia Ferroni, Luca BoniniAbstractThe pre-supplementary motor area F6 is involved in a variety of functions in multiple domains, from planning/withholding goal-directed actions in space to rule-based cognitive processes and social interactions. Yet, the neural machinery underlying this functional heterogeneity remains unclear. Here, we measured local population dynamics in different rostro-caudal sites of cytoarchitectonically verifie...
Source: Progress in Neurobiology - September 24, 2019 Category: Neuroscience Source Type: research
Thalamocortical processing of the head-direction sense
Publication date: Available online 21 September 2019Source: Progress in NeurobiologyAuthor(s): Adrien Peyrache, Adrian J Duszkiewicz, Guillaume Viejo, Sandybel Angeles-DuranAbstractOur thoughts and sensations are examples of cognitive processes that emerge from the collective activity of billions of neurons in the brain. Thalamocortical circuits form the canonical building-blocks of the brain networks supporting the most complex cognitive functions. How these neurons communicate and interact has been the focus of extensive research in “classical” sensory systems. Similar to visual, auditory or somatosensory thalamic pa...
Source: Progress in Neurobiology - September 22, 2019 Category: Neuroscience Source Type: research
Repeat-associated non-AUG (RAN) translation mechanisms running into focus for GGGGCC-repeat associated ALS/FTD
Publication date: Available online 21 September 2019Source: Progress in NeurobiologyAuthor(s): Lindsey D. Goodman, Nancy M. BoniniABSTRACTMany human diseases are associated with the expansion of repeat sequences within the genes. It has become clear that expressed disease transcripts bearing such long repeats can undergo translation, even in the absence of a canonical AUG start codon. Termed “RAN translation” for repeat associated non-AUG translation, this process is becoming increasingly prominent as a contributor to these disorders. Here we discuss mechanisms and variables that impact translation of the repeat sequen...
Source: Progress in Neurobiology - September 22, 2019 Category: Neuroscience Source Type: research
3D cellular reconstruction of cortical glia and parenchymal morphometric analysis from Serial Block-Face Electron Microscopy of juvenile rat
Publication date: Available online 21 September 2019Source: Progress in NeurobiologyAuthor(s): Corrado Cali, Marco Agus, Kalpana Kare, Daniya J. Boges, Heikki Lehvaslaiho, Markus Hadwiger, Pierre J. MagistrettiAbstractWith the rapid evolution in the automation of serial electron microscopy in life sciences, the acquisition of terabyte-sized datasets is becoming increasingly common. High resolution serial block-face imaging (SBEM) of biological tissues offers the opportunity to segment and reconstruct nanoscale structures to reveal spatial features previously inaccessible with simple, single section, two-dimensional images,...
Source: Progress in Neurobiology - September 22, 2019 Category: Neuroscience Source Type: research
Platelets: the missing link between the blood and brain?
Publication date: Available online 21 September 2019Source: Progress in NeurobiologyAuthor(s): Odette Leiter, Tara L. WalkerAbstractIt is becoming increasingly clear that interactions between the peripheral immune system and the central nervous system are important in maintaining healthy brain function. Platelets are small blood cells traditionally known for their role in wound healing. However, platelets have recently been shown to exhibit many alternative functions. In this perspective, we summarize the repertoire of platelet functions, focusing on how these cells contribute to the maintenance of brain homeostasis and pr...
Source: Progress in Neurobiology - September 22, 2019 Category: Neuroscience Source Type: research
