Conserved and divergent expression dynamics during early patterning of the telencephalon in mouse and chick embryos

Publication date: Available online 14 December 2019Source: Progress in NeurobiologyAuthor(s): Vijaykumar Yogesh Muley, Carlos Javier López-Victorio, Jorge Tonatiuh Ayala-Sumuano, Adriana González-Gallardo, Leopoldo González-Santos, Carlos Lozano-Flores, Gregory Wray, Maribel Hernández, Alfredo Varela-EchavarríaAbstractThe mammalian and the avian telencephalon are nearly indistinguishable at early embryonic vesicle stages but differ substantially in form and function at their adult stage. We sequenced and analyzed RNA populations present in mouse and chick during the early stages of embryonic telencephalon to understand conserved and lineage-specific developmental differences. We found approximately 3,000 genes that orchestrate telencephalon development. Many chromatin-associated epigenetic and transcription regulators were highly expressed in both species and some showed species-specific expression dynamics. Interestingly, previous studies associated them to autism, intellectual disabilities, and mental retardation supporting a causal link between their impaired functions during telencephalon development and brain dysfunction. Most striking was the finding that conserved up-regulated genes were differentially enriched in ontologies related to development or functions of the adult brain. Moreover, a differential enrichment of distinct repertoires of transcription factor binding motifs in their upstream promoter regions suggest a species-specific regulation of the various ...
Source: Progress in Neurobiology - Category: Neuroscience Source Type: research