Mitochondrial Degradation of Amyloidogenic Proteins—A New Perspective for Neurodegenerative Diseases

Publication date: Available online 10 July 2019Source: Progress in NeurobiologyAuthor(s): Janin Lautenschäger, Gabriele S. Kaminski SchierleAbstractThis perspective article outlines mechanisms of mitochondrial import and protein degradation and how these have been linked to alpha-synuclein and Amyloid beta (Aβ) homeostasis. Our aim is to underpin and stimulate the debate on the recent conception of mitochondria as protein degrading organelles, which suggests that mitochondria are more directly involved in neurodegenerative diseases than previously assumed.
Source: Progress in Neurobiology - Category: Neuroscience Source Type: research