The role of GLP‐1 receptor agonists as weight loss agents in patients with and without type 2 diabetes
Abstract
Obesity contributes to the pathogenesis of type 2 diabetes (T2DM) and cardiovascular disease. A modest weight loss of 5–10% can have significant impact on glucose control, medications use and patients’ functionality and quality of life. Until recently, only orlistat was approved in Europe for weight loss. Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) have been shown to improve glycaemia in patients with T2DM with an added benefit of weight reduction. However, the weight loss varies considerably within class and between individuals with up to 30% of patients not losing weight with GLP‐1 RA treat...
Source: Practical Diabetes - October 16, 2015 Category: Endocrinology Authors: Shujah Dar, Abd A Tahrani, Milan K Piya Tags: Review Source Type: research
New treatments for type 2 diabetes: are we any closer to reducing iatrogenic hypoglycaemia?
Abstract
The barrier of iatrogenic hypoglycaemia has limited the utility and safety of conventional diabetes medications. Novel agents for type 2 diabetes aim to surmount the impediment of iatrogenic hypoglycaemia and unmask the full realisation and benefits of achieving sustained euglycaemia over a lifetime of diabetes.
This review aims to critically consider the risk of iatrogenic hypoglycaemia allied with newer agents for type 2 diabetes, used alone and in combination with other diabetes therapies, and how this risk can be minimised. Copyright © 2015 John Wiley & Sons. Copyright © 2015 John Wiley & Sons, Ltd. ...
Source: Practical Diabetes - October 16, 2015 Category: Endocrinology Authors: Jason Seewoodhary, Stephen Phooi Yew Wong, Kaharanthilaka Poojanie Ekanayake Tags: Review Source Type: research
Cardiovascular outcome trials of glucose‐lowering drugs in type 2 diabetes: 10 frequently asked questions
(Source: Practical Diabetes)
Source: Practical Diabetes - October 16, 2015 Category: Endocrinology Authors: Jyothis T George Tags: Short report Source Type: research
Prescribing of medicines for diabetes in primary care in England
(Source: Practical Diabetes)
Source: Practical Diabetes - October 16, 2015 Category: Endocrinology Authors: Steve Chaplin Tags: Short report Source Type: research
New NICE guidelines on diabetic foot disease prevention and management
(Source: Practical Diabetes)
Source: Practical Diabetes - October 16, 2015 Category: Endocrinology Authors: David Coppini Tags: NICE guidelines commentary Source Type: research
Type 1 and type 2 diabetes in children and young people: updated NICE guidance
(Source: Practical Diabetes)
Source: Practical Diabetes - October 16, 2015 Category: Endocrinology Authors: Astha Soni, Sze May Ng Tags: NICE guidelines commentary Source Type: research
Type 1 diabetes in adults: new NICE guidance on diagnosis and management
(Source: Practical Diabetes)
Source: Practical Diabetes - October 16, 2015 Category: Endocrinology Authors: Ruth Poole Tags: NICE guidelines commentary Source Type: research
Type 2 diabetes: complex, crowded and costly
(Source: Practical Diabetes)
Source: Practical Diabetes - October 1, 2015 Category: Endocrinology Authors: Rustam Rea Tags: Leader Source Type: research
Fludrocortisone
(Source: Practical Diabetes)
Source: Practical Diabetes - September 10, 2015 Category: Endocrinology Authors: Nicholas Holt, Gerry McKay, Miles Fisher Tags: Drug notes Source Type: research
SGLT2 inhibitors and the risk of diabetic ketoacidosis
We describe a 58‐year‐old lady who had a presumed diagnosis of type 2 diabetes treated with metformin and a twice‐daily biphasic insulin regimen. She was commenced on dapagliflozin by her general practitioner and her blood glucose levels fell significantly over a period of several weeks leading, on occasions, to hypoglycaemia. Consequently, steady insulin dose reductions were made over this period leading eventually to the complete withdrawal of insulin treatment. Within 36 hours of the cessation of insulin treatment the patient was admitted to hospital as an emergency with severe diabetic ketoacidosis (DKA), requiri...
Source: Practical Diabetes - September 10, 2015 Category: Endocrinology Authors: Christopher Redford, Laura Doherty, Jamie Smith Tags: Case report Source Type: research
Easing diabetes’ psychological burden
(Source: Practical Diabetes)
Source: Practical Diabetes - September 10, 2015 Category: Endocrinology Authors: Mark Greener Tags: Policy profile Source Type: research
‘Saturated fat doesn't increase coronary heart disease in people with diabetes’
(Source: Practical Diabetes)
Source: Practical Diabetes - September 10, 2015 Category: Endocrinology Authors: Trudi Deakin, Leonie Garden Tags: Debate Source Type: research
Diabetes Insulin Guidance System: a real‐world evaluation of new technology (d‐Nav) to achieve glycaemic control in insulin‐treated type 2 diabetes
In conclusion, d‐Nav is shown to be a safe and effective solution for blood glucose management in insulin users with type 2 diabetes. Copyright © 2015 John Wiley & Sons. (Source: Practical Diabetes)
Source: Practical Diabetes - September 10, 2015 Category: Endocrinology Authors: R Donnelly, S Carr, R Harper Tags: Original article Source Type: research
Setting occupational standards for insulin‐treated diabetes at sea, on land and in the air
Abstract
Diabetes, particularly treatment with insulin, has proved a longstanding and frustrating barrier to employment in certain occupations where public safety has been deemed to be potentially at risk. Historically, health and safety issues within the work environment have dictated employment policy, precluding people with diabetes who would otherwise be entirely capable of undertaking required responsible and skilled activities. Such considerations have been especially evident for professional occupations involving both commercial and public transport on land, by sea and in the air. This situation is changing. With th...
Source: Practical Diabetes - September 10, 2015 Category: Endocrinology Authors: Ken Shaw Tags: Review Source Type: research
Insulin‐treated diabetes and motorised transport: key factors for patient and clinician
(Source: Practical Diabetes)
Source: Practical Diabetes - September 10, 2015 Category: Endocrinology Authors: Clive Morrison Tags: Commentary Source Type: research
