From Enzymology to Systems Biology and Back-Prologue
Publication date: Available online 1 September 2016 Source:Perspectives in Science Author(s): Carsten Kettner, Martin G. Hicks (Source: Perspectives in Science)
Source: Perspectives in Science - September 1, 2016 Category: Science Source Type: research
Finding homes for orphan enzymes
Publication date: Available online 31 August 2016 Source:Perspectives in Science Author(s): Frank M. Raushel The rate at which new genes are being sequenced greatly exceeds our ability to correctly annotate the functional properties of the corresponding proteins. Annotations based primarily on sequence identity to experimentally characterized proteins are often misleading because closely related sequences may have different functions, while highly divergent sequences may have identical functions. Our understanding of the principles that dictate the catalytic properties of enzymes, based on protein sequence alone, is oft...
Source: Perspectives in Science - August 30, 2016 Category: Science Source Type: research
Computational approaches for the study of the role of small molecules in diseases
Publication date: Available online 26 August 2016 Source:Perspectives in Science Author(s): Monica Campillos An enormous amount of molecular and phenotypic information of drugs as well as diseases is now available in public repositories. Computational analysis of these datasets is facilitating the acquisition of a systems view of how drugs act on our human organism and interfere with diseases. Here, I highlight recent approaches integrating large-scale information of drugs and diseases that are contributing to change our current view on how drugs interfere with human diseases. (Source: Perspectives in Science)
Source: Perspectives in Science - August 26, 2016 Category: Science Source Type: research
Reconstruction of ancestral enzymes
We present several examples of ASR and the subsequent experimental characterization of enzymes as old as four billion years. The results show that most ancestral enzymes were highly thermostable and catalytically active. Moreover, they adopted three-dimensional structures similar to those of extant enzymes. These findings suggest that sophisticated enzymes were invented at a very early stage of biological evolution. (Source: Perspectives in Science)
Source: Perspectives in Science - August 26, 2016 Category: Science Source Type: research
In search of lost time constants and of non-Michaelis –Menten parameters
Publication date: Available online 27 August 2016 Source:Perspectives in Science Author(s): Maria F. Pinto, Pedro M. Martins Upon completing 100 years since it was published, the work Die Kinetik der Invertinwirkung by Michaelis and Menten (MM) was celebrated during the 6th Beilstein ESCEC Symposium 2013. As the 7th Beilstein ESCEC Symposium 2015 debates enzymology in the context of complex biological systems, a post-MM approach is required to address cell-like conditions that are well beyond the steady-state limitations. The present contribution specifically addresses two hitherto ambiguous constants whose interest wa...
Source: Perspectives in Science - August 26, 2016 Category: Science Source Type: research
VLSI Systems Energy Management from a Software Perspective-A Literature Survey
Publication date: Available online 4 July 2016 Source:Perspectives in Science Author(s): Prasada Kumari K.S., Sampath Kumar, Shivaji Sinha The increasing demand for ultra-low power electronic systems has motivated research in device technology and hardware design techniques. Experimental studies have proved that the hardware innovations for power reduction are fully exploited only with the proper design of upper layer software. Also, the software power and energy modeling and analysis- the first step towards energy reduction is complex due to the inter and intra dependencies of processors, operating systems, applicati...
Source: Perspectives in Science - August 16, 2016 Category: Science Source Type: research
Analytical modelling of trio-optical asymmetrical microring resonator with vertical coupling
Publication date: Available online 9 July 2016 Source:Perspectives in Science Author(s): Suchita Lakra, Sanjoy Mandal Modelling of vertically coupled trio-optical microring resonator (VCTOMRR) with asymmetrical rings is developed in theory by applying delay line signal processing method. The frequency simulated response characteristic and its dispersion and group delay characteristics are advanced using MATLAB environment. The effectiveness of VCTOMRR with regard to free spectral range (FSR) and crosstalk is obtained from the different performance graphs. This proposed VCTOMRR can provide very wide FSR of 50.1nm range ...
Source: Perspectives in Science - August 5, 2016 Category: Science Source Type: research
Experimental study on two-phase flow pressure drop in small diameter bends
Publication date: Available online 5 July 2016 Source:Perspectives in Science Author(s): A.T. Autee, S.V. Giri Measurement of two-phase flow pressure drop and its prediction across curved tubes and bends is important for the enhancement of the performance and safety of the heat exchangers and flow transmitting devices. The comparative study of some of the available two-phase pressure drop correlations reveals that the predicted values of pressure drops by these leading methods may differ by large. The applicability of these correlations to the small diameter tubes of range 4.0–8.0mm and different bend angles of the r...
Source: Perspectives in Science - August 4, 2016 Category: Science Source Type: research
Power flow and small signal stability analysis on the interconnected Philippine power grid
Publication date: Available online 18 July 2016 Source:Perspectives in Science Author(s): Tristan Jr. G. Magallones, Jai Govind Singh, Watcharakorn Pinthurat The Philippines, as one of the developing nations in south-east Asia, has isolated power system networks which bring forth challenges in its operational systems, especially when subjected to a deregulated environment. This paper presents an analysis on the power flow and small signal stability of the interconnected three isolated Philippine Power Grid. To achieve this, eigenvalue analysis is employed to probe the small signal stability of the main power grids. Th...
Source: Perspectives in Science - August 4, 2016 Category: Science Source Type: research
Synthesis and characterization of Ag nanowires: Improved performance in dye sensitized solar cells
Publication date: Available online 5 July 2016 Source:Perspectives in Science Author(s): Safia A. Kazmi, Salman Hameed, Ameer Azam Development of highly efficient dye-sensitized solar cells (DSSCs) with good photovoltaic parameters is an active research area of current global interest. Recently, one dimensional nanomaterial, such as nanorods and nanotubes has replaced the nanoparticles used in DSSCs anode because of their ability to improve the electron transport leading to enhanced electron collection efficiency. In the present work, rapid synthesis of silver nanowires (AgNWs) was done. The XRD characterization was p...
Source: Perspectives in Science - August 3, 2016 Category: Science Source Type: research
Exploring and analyzing Internet crimes and their behaviours
Publication date: Available online 5 July 2016 Source:Perspectives in Science Author(s): Bhavna Arora The world today is experiencing an exponential growth in cyberspace. Nevertheless, India too has witnessed a significant ascend in Internet activities and it is quite assertive to say that such phenomenal growth in access to information on one hand leads to empowered individuals and organization and on the other hand also poses new challenges to government and citizens. To make the cyber world safe is the need of the hour. Putting up deterrent measures against cybercrime is essential to national cyber security in pro...
Source: Perspectives in Science - July 28, 2016 Category: Science Source Type: research
Kinematic modelling of a five-DOFs spatial manipulator used in robot-assisted surgery
Publication date: Available online 11 July 2016 Source:Perspectives in Science Author(s): Shakti Singh, Ashish Singla, Amanpreet Singh, Sanjeev Soni, Sanjeev Verma Since last three decades, research in the field of robot kinematics is boosted-up among different researchers worldwide. This is mainly due to their increased use in various challenging fields of engineering and science. One such challenging application is the use of master–slave concept in a robot-assisted surgery. The authors have already performed the kinematic study and gravity balancing of seven degrees-of-freedom (DOFs) surgeon-side manipul...
Source: Perspectives in Science - July 28, 2016 Category: Science Source Type: research
Wave interaction with Very Large Floating Structure (VLFS) using BEM approach – Revisited
Publication date: Available online 5 July 2016 Source:Perspectives in Science Author(s): Anoop I. Shirkol, T. Nasar, D. Karmakar In the present study, a brief discussion on the hydroelastic analysis of VLFS using Boundary Element Method (BEM) with basic assumptions, boundary conditions and support conditions required are presented. An overview of present scenario about development of VLFS using BEM and also future prospects are presented. The study on existing VLFS systems floated in the sea around world could be considered as indicative of the present state of affairs. Further, various numerical methods adopted ...
Source: Perspectives in Science - July 26, 2016 Category: Science Source Type: research
Template security analysis of multimodal biometric frameworks based on fingerprint and hand geometry
Publication date: Available online 5 July 2016 Source:Perspectives in Science Author(s): Arvind Selwal, Sunil Kumar Gupta, Surender, Anubhuti Biometric systems are automatic tools used to provide authentication during various applications of modern computing. In this work, three different design frameworks for multimodal biometric systems based on fingerprint and hand geometry modalities are proposed. An analysis is also presented to diagnose various types of template security issues in the proposed system. Fuzzy analytic hierarchy process (FAHP) is applied with five decision parameters on all the designs and...
Source: Perspectives in Science - July 26, 2016 Category: Science Source Type: research
Modelling and simulation of basic robotic configurations using D –H parameters based adaptive modules
Publication date: Available online 5 July 2016 Source:Perspectives in Science Author(s): Satwinder Singh, Ekta Singla Selection of a suitable robotic manipulator, out of the available conventional configurations, is one way to employ a robot. However, with the increasing applications of robotic assistance, the concept of task-oriented customised design for prescribed working locations in a given environment, has got attention of several researchers. One of the challenges in this direction is the realisation of specific designs, involving unconventional values of robotic parameters. This paper discusses the D–H pa...
Source: Perspectives in Science - July 26, 2016 Category: Science Source Type: research
