Mesenchymal stem cells from the oral cavity and their potential value in tissue engineering
Abstract
Periodontal disease is one of the most common conditions affecting humans, and current treatment strategies, which focus on the removal and long‐term control of dental plaque, are generally successful in eliminating active disease and promoting tissue repair. However, regeneration of the supporting structures of the tooth remains an elusive goal and a challenge. The formation of new bone and cementum with supportive periodontal ligament is the ultimate objective, but current regeneration therapies are incapable of achieving this in a predictable way. The regeneration of periodontal tissue requires a combination ...
Source: Periodontology 2000 - December 12, 2014 Category: Dentistry Authors: Antonio R. Sanz, Flavio S. Carrión, Alejandra P. Chaparro Tags: Review Article Source Type: research
Research on growth factors in periodontology
Abstract
Growth factors play critical roles in periodontal repair through the regulation of cell behavior. Many of the cell responses regulated by these proteins include cell adhesion, migration, proliferation and differentiation. Periodontal regeneration involves an organized response of different cells, tissues and growth factors implicated in the coordination of these events. However, periodontal tissue reconstruction is an extremely difficult task. Multiple studies have been performed to understand the specific role of growth factors in periodontal wound healing. In the present review we analyze the evidence that suppo...
Source: Periodontology 2000 - December 12, 2014 Category: Dentistry Authors: Patricio C. Smith, Constanza Martínez, Mónica Cáceres, Jorge Martínez Tags: Review Article Source Type: research
Cementum proteins: role in cementogenesis, biomineralization, periodontium formation and regeneration
Abstract
Destruction of the periodontium is normally associated with periodontal disease, although many other factors, such as trauma, aging, infections, orthodontic tooth movement and systemic and genetic diseases, can contribute to this process. Strategies (such as guided tissue regeneration) have been developed to guide and control regeneration using bioresorbable membranes and bone grafts. Although effective to a certain point, these strategies have the problem that they are not predictable and do not completely restore the architecture of the original periodontium. To achieve complete repair and regeneration it is nec...
Source: Periodontology 2000 - December 12, 2014 Category: Dentistry Authors: Higinio Arzate, Margarita Zeichner‐David, Gabriela Mercado‐Celis Tags: Review Article Source Type: research
Current perspective of the impact of smoking on the progression and treatment of periodontitis
Abstract
This literature review provides an overview of the current scenario regarding the impact of smoking on the progression and treatment of periodontitis; clinical, microbiological and immunological data from studies from our and other groups are presented. In general, preclinical and clinical data are unanimous in demonstrating that smokers present increased susceptibility, greater severity and faster progression of periodontal disease compared with nonsmokers. The evidence further demonstrates that smokers lose more teeth and have a less favorable response to therapy than do nonsmokers. Although it is well establish...
Source: Periodontology 2000 - December 12, 2014 Category: Dentistry Authors: Francisco H. Nociti, Marcio Z. Casati, Poliana Mendes Duarte Tags: Review Article Source Type: research
Systemic antibiotics in the treatment of periodontitis
This article endeavored to provide a ‘state of the art’ overview on the use of systemic antibiotics in the treatment of periodontitis, based on the most recent literature on the topic as well as on a compilation of data from studies conducted at the Center of Clinical Trials at Guarulhos University (São Paulo, Brazil) from 2002 to 2012. (Source: Periodontology 2000)
Source: Periodontology 2000 - December 12, 2014 Category: Dentistry Authors: Magda Feres, Luciene C. Figueiredo, Geisla M. Silva Soares, Marcelo Faveri Tags: Review Article Source Type: research
