Eosinophil Counts in Mucosal Biopsies of the Ileum and Colon: Interobserver Variance Affects Diagnostic Accuracy.
Authors: Hentschel F, Jansen AF, Günther M, Pauli R, Lüth S
Abstract
Primary eosinophilic gastroenteritis and colitis (EGE) is a rare entity with unspecific clinical and endoscopic findings. Validated histopathologic criteria for confirming the diagnosis are lacking, because numeric values for normal or elevated concentrations of eosinophils in mucosal biopsies are varying between observers. To quantify this interobserver variance, we had the same set of 30 slides of eosinophilic-rich mucosal biopsies from the ileum and colon systematically reviewed by a panel of six independent pathologists, each with m...
Source: Pathology Research International - December 7, 2018 Category: Pathology Tags: Patholog Res Int Source Type: research
Wound Fluid Matrix Metalloproteinase-9 as a Potential Predictive Marker for the Poor Healing Outcome in Diabetic Foot Ulcers.
Conclusion: These findings suggested that determination of wound fluid MMP-9 levels might become a promising biomarker predicting wound healing outcomes and a novel potential therapeutic target for diabetic foot ulcers.
PMID: 30410716 [PubMed] (Source: Pathology Research International)
Source: Pathology Research International - November 10, 2018 Category: Pathology Tags: Patholog Res Int Source Type: research
HER2 Basolateral versus Circumferential IHC Expression Is Dependent on Polarity and Differentiation of Epithelial Cells in Gastric/GE Adenocarcinoma.
Conclusion: These findings suggest that HER2 in gastric epithelium has a polarized distribution which is maintained by the fence function of tight junctions. With progression to high grade cancer, the glandular structural differentiation in gastric mucosa is lost, along with disruption of tight junctions. This leads to loss of cell polarity and migration of antigens across the membrane.
PMID: 30140423 [PubMed] (Source: Pathology Research International)
Source: Pathology Research International - August 25, 2018 Category: Pathology Tags: Patholog Res Int Source Type: research
Prognostic Factors in Anti-Neutrophil Cytoplasmic Antibody-Associated Glomerulonephritis with Severe Glomerular Sclerosis: A National Registry-Based Cohort Study.
Conclusions: eGFR and percentage of normal glomeruli are strong risk factors for ESRD in ANCA-GN with sclerosing histology.
PMID: 29973979 [PubMed] (Source: Pathology Research International)
Source: Pathology Research International - July 6, 2018 Category: Pathology Tags: Patholog Res Int Source Type: research
CD20+ Tumor Infiltrating B Lymphocyte in Oral Squamous Cell Carcinoma: Correlation with Clinicopathologic Characteristics and Heat Shock Protein 70 Expression.
Conclusion: The results suggest that peritumoral B lymphocyte infiltration and HSP70 expression level have significant association with OSCC and may be considered as prognostic indicators in OSCC. Thus, evaluation of B cells as therapeutic targets in OSCC patients is recommended.
PMID: 29850009 [PubMed] (Source: Pathology Research International)
Source: Pathology Research International - June 4, 2018 Category: Pathology Tags: Patholog Res Int Source Type: research
The Role of Osteocalcin and Alkaline Phosphatase Immunohistochemistry in Osteosarcoma Diagnosis.
Conclusion: ALP immunohistochemistry is useful in discriminating OSA from OPBT. ALP is superior to OCN in OSA diagnosis. OCN cannot be used to differentiate between OSA and OPBT.
PMID: 29854380 [PubMed] (Source: Pathology Research International)
Source: Pathology Research International - June 4, 2018 Category: Pathology Tags: Patholog Res Int Source Type: research
Accelerated Blood Clearance (ABC) Phenomenon Favors the Accumulation of Tartar Emetic in Pegylated Liposomes in BALB/c Mice Liver.
Authors: Lopes TCM, Silva DF, Costa WC, Frézard F, Barichello JM, Silva-Barcellos NM, de Lima WG, Rezende SA
Abstract
Tartar emetic (TE) was the first drug used to treat leishmaniasis. However, its use was discontinued due to high toxicity. Association of TE with liposomes is a strategy to reduce its side effects. Pegylated liposomes (Lpeg) present lower rates of uptake by macrophages and prolonged circulation compared to their nonpegylated counterparts. However, repeated administration of Lpeg can cause an Accelerated Blood Clearance (ABC) phenomenon, whereby recognition of liposomes by antibodies result...
Source: Pathology Research International - March 30, 2018 Category: Pathology Tags: Patholog Res Int Source Type: research
Histopathologic and Cytologic Follow-Up in High Risk Male Patients with Unsatisfactory Anal Cytology.
CONCLUSIONS: High risk male patients with unsatisfactory Pap smears are at significant risk of epithelial cell abnormality and histopathologically verifiable anal intraepithelial lesions.
PMID: 29075548 [PubMed] (Source: Pathology Research International)
Source: Pathology Research International - October 28, 2017 Category: Pathology Tags: Patholog Res Int Source Type: research
An Attempt to Establish a Common Animal Model for Hepatorenal Fibrosis in Rats.
In this study, we were able to induce significant fibrosis in the liver and early stages of fibrosis in the kidneys. The result also demonstrated that the addition of BSA conferred a liver protective effect against CCl4 induced hepatotoxicity, whereas combination of CCl4 and BSA proved to be detrimental for kidneys.
PMID: 28835866 [PubMed] (Source: Pathology Research International)
Source: Pathology Research International - August 25, 2017 Category: Pathology Tags: Patholog Res Int Source Type: research
Development of Neurological Mouse Model for Toxoplasmosis Using Toxoplasma gondii Isolated from Chicken in Kenya.
In this study, a neurological mouse model was developed in BALB/c mice infected intraperitoneally with 15 cysts of a Toxoplasma gondii isolate. The mice were monitored for 42 days and euthanized at different time points. Another group of mice were orally treated with dexamethasone (DXM: 2.66 mg/kg daily, 5.32 mg/kg daily) at 42 days after infection and monitored for a further 42 days. A mortality rate of 15% and 28.6% was observed in mice given 2.66 mg/kg/day and 5.32 mg/kg/day of DXM, respectively. The mean cyst numbers in the brain of DXM treated mice increased up to twofold compared with chronically infected unt...
Source: Pathology Research International - June 22, 2017 Category: Pathology Tags: Patholog Res Int Source Type: research
High Expression of Galectin-3 in Patients with IgG4-Related Disease: A Proteomic Approach.
CONCLUSION: Galectin-3 was overexpressed in IgG4-RD and the levels were indirectly related to clinical activity.
PMID: 28593065 [PubMed - in process] (Source: Pathology Research International)
Source: Pathology Research International - June 9, 2017 Category: Pathology Tags: Patholog Res Int Source Type: research
Utility of Immunohistochemistry and ETV6 (12p13) Gene Rearrangement in Identifying Secretory Carcinoma of Salivary Gland among Previously Diagnosed Cases of Acinic Cell Carcinoma.
Conclusions. Characteristic immunoprofile and ETV6 gene rearrangement may prove useful in identifying cases of SC. The presence of ETV6 3' interstitial deletion in one of our cases suggests that there may be additional ETV6 related genetic alterations contributing to the pathogenesis of SC.
PMID: 28484662 [PubMed - in process] (Source: Pathology Research International)
Source: Pathology Research International - May 11, 2017 Category: Pathology Tags: Patholog Res Int Source Type: research
Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: An Evidence-Based Nomenclature Change.
Authors: Jug R, Jiang X
Abstract
A consensus panel recently used clinical evidence and pathologic parameters to rename noninvasive encapsulated follicular variant of papillary thyroid carcinoma to noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) to better reflect the indolent course of this tumor. NIFTP has stringent histopathologic diagnostic criteria established by the panel, including papillary-like nuclear features, and submission of the entire tumor capsule to exclude invasion. From a molecular standpoint, NIFTP is often characterized by RAS-type mutations, similar ...
Source: Pathology Research International - March 11, 2017 Category: Pathology Tags: Patholog Res Int Source Type: research
Pathologic and Radiologic Correlation of Adult Cystic Lung Disease: A Comprehensive Review.
Authors: Boddu P, Parimi V, Taddonio M, Kane JR, Yeldandi A
Abstract
The presence of pulmonary parenchymal cysts on computed tomography (CT) imaging presents a significant diagnostic challenge. The diverse range of possible etiologies can usually be differentiated based on the clinical setting and radiologic features. In fact, the advent of high-resolution CT has facilitated making a diagnosis solely on analysis of CT image patterns, thus averting the need for a biopsy. While it is possible to make a fairly specific diagnosis during early stages of disease evolution by its characteristic radiological prese...
Source: Pathology Research International - March 10, 2017 Category: Pathology Tags: Patholog Res Int Source Type: research
Immunohistochemical Investigation of HER/AKT/mTOR Pathway and Cellular Adhesion Molecules in Urothelial Carcinomas.
Conclusions. HER2 overexpression is found in a respective proportion of urothelial carcinomas. P-cadherin expression is associated with high grade UCs but it is not affected by HER2 overexpression or by activation of HER/AKT/mTOR pathway.
PMID: 28210516 [PubMed - in process] (Source: Pathology Research International)
Source: Pathology Research International - February 18, 2017 Category: Pathology Tags: Patholog Res Int Source Type: research
