Value of Procollagen Type I Aminoterminal Propeptide in Women with Breast Cancer with regard to Metastases.
Conclusion. The marker of bone turnover procollagen type 1 aminoterminal propeptide can be considered as a useful tool for estimating the extent of bone involvement and for the detection of bone metastases. P1NP cannot replace conventional methods for detecting bone metastases such as radiological methods but it can help clarify unclear radiological results. This study does not take into account the change of P1NP concentration during the course of therapy.
PMID: 22135768 [PubMed] (Source: Pathology Research International)
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Intracranial Aspergillus granuloma.
Authors: Sundaram C, Murthy JM
Abstract
Intracranial fungal granulomas are rare and of the histologically verified granulomas, Aspergillus spp. is the commonest causative fungal pathogen. Most of the reported large series of aspergillus granulomas are from countries with temperate climate like India, Pakistan, Sudan, and Saudi Arabia. In contrast to disseminated aspergillosis that occurs in immunosuppressed individuals, most of the intracranial aspergillus granulomas are reported in immunocompetent individuals. The temperature, humidity, high spore content in the atmosphere during ploughing, and occupation...
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Microbiological spectrum of brain abscess at a tertiary care hospital in South India: 24-year data and review.
Authors: Lakshmi V, Umabala P, Anuradha K, Padmaja K, Padmasree C, Rajesh A, Purohit AK
Abstract
Intracranial abscesses are life-threatening infections that pose a diagnostic challenge not only to the neurosurgeon but also to the microbiologists. Detailed studies documenting the spectrum of infecting agents involved in brain abscesses are limited from India. Materials and Methods. This is a retrospective analysis of 352 samples from 1987 to 2010 analyzed at a tertiary care hospital in South India from 1987 to 2010, to document the changing trends with time. Results. The age of the patients ranged from 2 to...
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Pathologic Features of Behçet's Disease in the Tubuler Gut.
Authors: Kara T, Düşmez Apa D
Abstract
Behçet's disease (BD) is a vasculitic disorder of relapsing acute inflammation characterized by recurrent oral ulcers, genital ulcers, uveitis, and skin lesions. The disease also affects other organs, including joints, the nervous system, blood vessels, and gastrointestinal (GI) system may also be involved and the lower GI tract is the mostly involved part, leading to severe morbidity. The frequency of GI involvement in BD varies among different ethnic groups. Although 50-60% of Japanese patients have GI disease, these manifestations are rare in patients from Medit...
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Clinical and Pathological Manifestations with Differential Diagnosis in Behçet's Disease.
Authors: Kokturk A
Abstract
Behçet's disease is a multisystemic inflammatory disease of unknown etiology which usually occurs as a trait of symptoms: aphthous stomatitis, genital ulcerations, and ocular disease. At the beginning of the disease the diagnosis is uncertain because of various clinical manifestations and a long period up to the full clinical picture manifestation. Since neither the laboratory data nor the histopathological signs are truly pathognomonic in Behçet's disease, the differential diagnosis depends on a careful evaluation of the medical history and meticulous physical examination to ...
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Behcet's Disease and Endocrine System.
Authors: Ozhan O, Sezer K
Abstract
Behcet's disease (BD) is a chronic disease which is characterized by recurrent oral apthous ulcerations, recurrent genital ulcerations, skin eruptions, ocular involvements and other various systemic manifestations as well as systemic vasculitis. Endocrine involvement in BD regarding various systems can be seen. Hypophysis is one of the best and dense vascularized organs of the body, thus it is likely that it can be affected by BD. Not only anterior hypophysis functions, but posterior hypophysis functions as well can be affected. As BD is a disease of autoimmune process, i...
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Potential Infectious Etiology of Behçet's Disease.
Authors: Galeone M, Colucci R, D'Erme AM, Moretti S, Lotti T
Abstract
Behçet's disease is a multisystem inflammatory disorder characterized by recurrent oral aphthous ulcers, genital ulcers, uveitis, and skin lesions. The cause of Behçet's disease remains unknown, but epidemiologic findings suggest that an autoimmune process is triggered by an environmental agent in a genetically predisposed individual. An infectious agent could operate through molecular mimicry, and subsequently the disease could be perpetuated by an abnormal immune response to an autoantigen in the absence of ongoing infection. Potenti...
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Pathology and diagnosis of central nervous system infections.
Authors: Sundaram C, Shankar SK, Thong WK, Pardo-Villamizar CA
PMID: 22315702 [PubMed] (Source: Pathology Research International)
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Head and neck pathology: new developments in the diagnosis and pathogenesis of head and neck tumors.
Authors: Pambuccian SE, Stelow EB, Koutlas IG, Thrall MJ
PMID: 22363899 [PubMed] (Source: Pathology Research International)
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Internal Quality Assurance Program for ERBB2 (HER2) Testing Improves the Selection of Breast Cancer Patients for Treatment with Trastuzumab.
Authors: Martin V, Camponovo A, Ghisletta M, Bongiovanni M, Mazzucchelli L
Abstract
International guidelines for ERBB2 (HER2) testing procedures in breast cancer patients highlight the importance of external quality control. In contrast, internal quality assurance programs have been poorly defined, and their clinical significance has not yet been investigated. We developed a quality assurance scheme by performing HER2 FISH on 724 patients randomly selected out of 1996 patients with breast cancer presenting at our institute. We collected samples monthly for tissue microarray analysis and correlated HER2 gen...
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Automated measurement of immature granulocytes: performance characteristics and utility in routine clinical practice.
This study of 200 febrile patients aimed at analysing the performance characteristics of automated immature granulocytes (AIGs) in predicting blood culture and their clinical utility. The absolute (IGC) and relative IG count (IG%) had area under curve (AUC) of 0.69 and 0.66. Moreover, the means of IGC and IG% between culture positive and negative groups were statistically significant suggesting that they are potential markers for bacteremia. IGC of 0.03 × 10(3) cu·mm and IG% of 0.5% offered sensitivity of 86.3% and 92.2%, respectively, and may be used for screening for bacteremia. Higher values, IGC > 0.3, a...
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Gastric composite tumor of alpha fetoprotein-producing carcinoma/hepatoid adenocarcinoma and endocrine carcinoma with reference to cellular phenotypes.
We examined histological phenotype of tumors of AFPC or NEC containing the composite tumor by evaluating immunohistochemical expressions of MUC2, MUC5AC, MUC6, CDX2, and SOX2. Immunohistochemically, AFPC/HAC dominantly showed the intestinal or mixed phenotype, and NEC frequently showed the gastric phenotype. In the composite tumor, the tubular and hepatoid components showed the gastric phenotype, and the neuroendocrine component showed the mixed type. The unique composite tumor predominantly showed the gastric phenotype, and the hepatoid and neuroendocrine components were considered to be differentiated from the tubular co...
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Immunoreactivity of the 14F7 Mab (Raised against N-Glycolyl GM3 Ganglioside) as a Positive Prognostic Factor in Non-Small-Cell Lung Cancer.
Authors: Blanco R, Rengifo CE, Cedeño M, Frómeta M, Rengifo E, Carr A
Abstract
Lung carcinoma is the leading cause of cancer-related mortality worldwide. Therefore, numerous studies are focusing on the assessment of other biological and molecular prognostic factors in these tumors. We evaluated the relationship between 14F7 Mab reactivity, pathological features, DNA-content and S-phase fraction (SPF), and their impact in the survival of NSCLC patients. Hematoxylin and eosin staining and immunohistochemistry optical microscopy assays as well as DNA content and SPF measuring using flow cytometry were perfo...
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Animal Models in Behçet's Disease.
Authors: Yildirim O
Abstract
Behçet's disease is a chronic, recurrent, multisystemic, inflammatory disorder affecting mainly the oral and urogenital mucosa and the uveal tract. Although the etiology and pathogenesis of Behçet's disease are unknown, numerous etiologies have been proposed, including environmental, infectious, and immunological factors; an autoimmune basis, characterized by circulating immune complexes and complement activation, has gained increasing acceptance. To test and understand immunopathogenesis of Behçet's disease, animal models were developed based on enviromental pollutants, bac...
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Expression of CD44v6 and Its Association with Prognosis in Epithelial Ovarian Carcinomas.
In conclusion, these results suggest that CD44v6 may be related to histological type, FIGO stage and histological grade of ovarian carcinomas, and CD44v6 may be an important molecular marker for poor prognosis in ovarian carcinomas.
PMID: 22482084 [PubMed] (Source: Pathology Research International)
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
