Morphological and chemical study of pathological deposits in human aortic and mitral valve stenosis: a biomineralogical contribution.
Authors: Cottignoli V, Cavarretta E, Salvador L, Valfré C, Maras A
Abstract
Aim of this study was to investigate heart valve calcification process by different biomineralogical techniques to provide morphological and chemical features of the ectopic deposit extracted from patients with severe mitral and aortic valve stenosis, to better evaluate this pathological process. Polarized light microscopy and scanning electron microscopy analyses brought to light the presence of nodular and massive mineralization forms characterized by different levels of calcification, as well as the presence of submicrometric c...
Source: Pathology Research International - February 17, 2015 Category: Pathology Tags: Patholog Res Int Source Type: research
Use of fine-needle aspiration in the evaluation of breast lumps.
Conclusion. FNAC serves as a rapid, economical, and reliable tool for the diagnosis of palpable breast lesions because the cytopathological examination of these lesions before operation or treatment serves as an important diagnostic modality.
PMID: 21789264 [PubMed] (Source: Pathology Research International)
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Human Papillomavirus and Oropharyngeal Squamous Cell Carcinoma: A Case-Control Study regarding Tobacco and Alcohol Consumption.
In conclusion, HPV is strongly associated with OSCC of nonsmoking and nondrinking patients. Specific diagnostic and therapeutic actions should be considered for these patients to achieve a better prognosis.
PMID: 21789265 [PubMed] (Source: Pathology Research International)
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Fatal hemothorax caused by pseudomesotheliomatous carcinoma of the lung.
We present a case of a poorly differentiated pseudomesotheliomatous carcinoma originating in the lung, which was manifested with the distinctly rare complication of massive true hemothorax and persistent blood loss that proved rapidly fatal in spite of surgery. Pseudomesotheliomatous carcinoma of the lung and neoplasia-associated hemothorax are reviewed and discussed.
PMID: 21789266 [PubMed] (Source: Pathology Research International)
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Raman spectroscopic methods for classification of normal and malignant hypopharyngeal tissues: an exploratory study.
Authors: Pujary P, Maheedhar K, Krishna CM, Pujary K
Abstract
Laryngeal cancer is more common in males. The present study is aimed at exploration of potential of conventional Raman spectroscopy in classifying normal from a malignant laryngopharyngeal tissue. We have recorded Raman spectra of twenty tissues (aryepiglottic fold) using an in-house built Raman setup. The spectral features of mean malignant spectrum suggests abundance proteins whereas spectral features of mean normal spectrum indicate redundancy of lipids. PCA was employed as discriminating algorithm. Both, unsupervised and supervised modes of ...
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Clinical Significance of MicroRNA Expression Profiles and Polymorphisms in Lung Cancer Development and Management.
Authors: Megiorni F, Pizzuti A, Frati L
Abstract
Lung cancers account for a huge percentage of death in industrialized countries, and hence there is an increasing call for the development of novel treatments. These malignancies are caused by a combination of environmental factors, principally cigarette smoking and genetic alterations. MicroRNAs (miRNAs) are a recently discovered class of regulatory noncoding small RNAs with a significance in numerous biological processes. Strong evidence links miRNA impaired expression profiles and pathways to the etiology of several diseases, including neoplasia. This pap...
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
AIDS-Related Pathology.
Authors: Pantanowitz L, Carbone A, Stebbing J
PMID: 21845208 [PubMed] (Source: Pathology Research International)
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Disease Extent ≥4 cm Is a Prognostic Marker of Local Recurrence in T1-2 Breast Cancer.
Authors: Lindquist D, Hellberg D, Tot T
Abstract
Despite improvements of the therapy for breast cancer, a proportion of the patients still get local recurrence. The status of the surgical margins is the most often used parameter for decision regarding additional treatment. However, a negative margin is not a guarantee that there is not residual cancer left in the breast; additional parameters are needed to better predict the risk of local recurrence. The disease extent was evaluated in the surgical specimen from 313 women after breast-conserving therapy using large-section histology and was correlated to t...
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Histopathological and genomic grading provide complementary prognostic information in breast cancer: a study on publicly available datasets.
Authors: Chowdhury N
Abstract
The genomic grade (GG) for breast cancer is thought to be the genomic counterpart of histopathological grade (HG). The motivation behind this study was to see whether HG retains its prognostic impact even when adjusted for GG, or whether it can be replaced by the latter. Four publicly available gene expression datasets were analyzed. Kaplan-Meier curves, log rank test, and Cox regression were used to study recurrence-free survival (RFS) and distant metastasis-free survival (DMFS). HG remained a significant prognostic indicator in low GG tumors (P = 0.003 for DMFS, P< 0.001 ...
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Molecular bases of cutaneous and uveal melanomas.
Authors: Gaudi S, Messina JL
Abstract
Intensive research in recent years has begun to unlock the mysteries surrounding the molecular pathogenesis of melanoma, the deadliest of skin cancers. The high-penetrance, low-frequency susceptibility gene CDKN2A produces tumor suppressor proteins that function in concert with p53 and retinoblastoma protein to thwart melanomagenesis. Aberrant CDKN2A gene products have been implicated in a great many cases of familial cutaneous melanoma. Sporadic cases, on the other hand, often involve constitutive signal transduction along the mitogen-activated protein kinase (MAPK) p...
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Current concepts on dedifferentiation/high-grade transformation in salivary gland tumors.
Authors: Costa AF, Altemani A, Hermsen M
Abstract
The concept of dedifferentiation had previously been used in salivary gland carcinomas. Recently, the term "high-grade transformation" was introduced for adenoid cystic carcinoma, acinic cell carcinoma, epithelial-myoepithelial carcinoma, and polymorphous low-grade adenocarcinoma and may better reflect this phenomenon, although transformation into moderately differentiated adenocarcinoma (i.e., not "high grade") has also been described. Among the immunohistochemical markers, Ki-67 seems to be the only one that can help distinguish between the conventional a...
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Role of apoptosis in rabies viral encephalitis: a comparative study in mice, canine, and human brain with a review of literature.
Authors: Suja MS, Mahadevan A, Madhusudana SN, Shankar SK
Abstract
To evaluate the role of apoptosis in rabies encephalitis in humans and canines infected with wild-type street virus, in comparison with rodent model infected with street and laboratory passaged CVS strain, we studied postmortem brain tissue from nine humans, six canines infected with street rabies virus, and Swiss albino mice inoculated intramuscularly (IM) and intracerebrally (IC) with street and CVS strains. Encephalitis and high rabies antigen load were prominent in canine and human brains compared to rodents inoculated with street virus...
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
The interpretation of phrases used to describe uncertainty in pathology reports.
This study demonstrates that pathologists vary widely in how they interpret the meaning of phrases describing probability that are commonly used in pathology reports. We suggest that this potential risk is highlighted during pathology training.
PMID: 21876845 [PubMed] (Source: Pathology Research International)
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Effects of the demethylating agent, 5-azacytidine, on expression of the kallikrein-kinin genes in carcinoma cells of the lung and pleura.
Authors: Wong J, Sia YY, Misso NL, Aggarwal S, Ng A, Bhoola KD
Abstract
Tissue kallikrein (KLK1) and plasma kallikrein (KLKB1) may regulate the growth and proliferation of tumours of the lung and pleura, through the generation of kinin peptides that signal through the kinin B(1) (BDKRB1) and B(2) (BDKRB2) receptors. The development and progression of cancer results from genetic mutations, as well as epigenetic changes that include methylation of DNA at CpG islands. The aim of this study was to assess whether expression of the kallikrein-kinin genes in lung cancer and mesothelioma cells is regulated by DNA ...
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Prostatic adenocarcinoma metastatic to pleomorphic liposarcoma, a "collision phenomenon": report of a case with review of pelvic collision tumors.
We present the challenges encountered in the diagnosis of this case and review of pelvic collision tumors.
PMID: 21904691 [PubMed] (Source: Pathology Research International)
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
