Utility of tissue transglutaminase immunohistochemistry in pediatric duodenal biopsies: patterns of expression and role in celiac disease-a clinicopathologic review.
Authors: Almarzooqi S, Houston RH, Prasad V
Abstract
Tissue transglutaminase (tTG) is a ubiquitous multifunctional protein. It has roles in various cellular processes. tTG is a major target of autoantibodies in celiac disease, and its expression by immunohistochemistry in pediatric celiac disease has not been fully examined. We studied tTG expression in 78 pediatric duodenal biopsies by utilizing an antibody to transglutaminase 2. Serum tTG was positive in all celiac cases evaluated. Serum antiserum endomysial antibody (EMA) and tTG were negative in all control subjects and in inflammatory bowel disease an...
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Clinicopathological study of 25 cases of diverticular disease of the appendix: experience from farwaniya hospital.
Conclusions. DDA is a rare disease, and clinicians and radiologists should be aware of it. Male sex and adult age seem to be risk factors associated with DDA. The disease may not have any direct association with any neoplasm.
PMID: 24224113 [PubMed] (Source: Pathology Research International)
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
A compendium of urinary biomarkers indicative of glomerular podocytopathy.
Authors: Sekulic M, Pichler Sekulic S
Abstract
It is well known that glomerular podocyte injury and loss are present in numerous nephropathies and that the pathophysiologic consecution of disease hinges upon the fate of the podocyte. While multiple factors play a hand in glomerulopathy progression, basic logic lends that if one monitors the podocyte's status, that may reflect the status of disease. Recent investigations have focused on what one can elucidate from the noninvasive collection of urine, and have proven that certain, specific biomarkers of podocytes can be readily identified via varying techniq...
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
What We Have Learned about Autism Spectrum Disorder from Valproic Acid.
Authors: Chomiak T, Turner N, Hu B
Abstract
Two recent epidemiological investigations in children exposed to valproic acid (VPA) treatment in utero have reported a significant risk associated with neurodevelopmental disorders and autism spectrum disorder (ASD) in particular. Parallel to this work, there is a growing body of animal research literature using VPA as an animal model of ASD. In this focused review we first summarize the epidemiological evidence linking VPA to ASD and then comment on two important neurobiological findings linking VPA to ASD clinicopathology, namely, accelerated or early brain ov...
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Immunoreactivity of the 14F7 Mab Raised against N-Glycolyl GM3 Ganglioside in Primary Lymphoid Tumors and Lymph Node Metastasis.
Authors: Blanco R, Blanco D, Quintana Y, Escobar X, Rengifo CE, Osorio M, Gutiérrez Z, Lamadrid J, Cedeño M, Frómeta M, Carr A, Rengifo E
Abstract
The reactivity of the 14F7 Mab, a highly specific IgG1 against N-glycolyl GM3 ganglioside (NeuGcGM3) in normal tissues, lymphomas, lymph node metastasis, and other metastatic sites was assessed by immunohistochemistry. In addition, the effect of chemical fixation on the 14F7 Mab staining using monolayers of P3X63Ag.653 cells was also evaluated. Moreover, the ability of 14F7 to bind NeuGcGM3 ganglioside inducing complement-independent cytotoxicity by a flow cy...
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Specimens from biopsies of colorectal polyps often harbor additional diagnoses.
Conclusions. Specimens from biopsies of colorectal polyps often harbor other diagnoses, in addition to polyps, and can be simultaneously screened for polyps and examined for nonneoplastic diseases. Detection of other diagnoses in addition to polyps requires awareness, examination at high magnification, and examination of areas spared by the polyps.
PMID: 24455417 [PubMed] (Source: Pathology Research International)
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Evidences suggesting involvement of viruses in oral squamous cell carcinoma.
Authors: Gupta K, Metgud R
Abstract
Oral cancer is one of the most common cancers and it constitutes a major health problem particularly in developing countries. Oral squamous cell carcinoma (OSCC) represents the most frequent of all oral neoplasms. Several risk factors have been well characterized to be associated with OSCC with substantial evidences. The etiology of OSCC is complex and involves many factors. The most clearly defined potential factors are smoking and alcohol, which substantially increase the risk of OSCC. However, despite this clear association, a substantial proportion of patients develo...
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Cytological and Pathological Correlation of FNAC in Assessing Breast Lumps and Axillary Lymph Node Swellings in a Public Sector Hospital in India.
Conclusions. FNAC is rapid, accurate, outpatient based, and less complicated procedure and helps in diagnosis of breast cancer, benign diseases, and axillary involvement in experienced hands with less chance of false results.
PMID: 24455419 [PubMed] (Source: Pathology Research International)
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
A Comparison of Hemoglobin A2 Levels in Untreated and Treated Groups of HIV Patients on ART Including Zidovudine.
Conclusion. The clinicians, pathologists, haematologists, and genetic counsellors should be aware of effects of nutritional anaemia and ART on Hb A2 to reduce the chances of misdiagnosis of β -thalassaemia especially in developing countries and for centres for antenatal screening.
PMID: 24459601 [PubMed] (Source: Pathology Research International)
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Hospital-based study of epithelial malignancies of endometrial cancer frequency in lahore, pakistan, and common diagnostic pitfalls.
Authors: Tanvir I, Riaz S, Hussain A, Mehboob R, Shams MU, Khan HA
Abstract
The current study was conducted to see the frequency of epithelial malignancies of endometrium with focus on the common diagnostic pitfalls and identify morphological and immunohistochemical markers helpful in the differential diagnosis between different subtypes. It is a retrospective descriptive study carried out on 52 specimens of endometrial tumors received in Fatima Memorial Hospital, Lahore, Pakistan, during three years (2010-2012). Patients were divided into 5 age groups: <40, 41-50, 51-60, 61-70, and >70 yrs. Tissue...
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Trophoblastic infiltration in tubal pregnancy evaluated by immunohistochemistry and correlation with variation of Beta-human chorionic gonadotropin.
Conclusions. Our observations showed a direct correlation of increased levels of serum β -hCG in 48h period prior to surgery with higher trophoblastic cell proliferation assessed by Ki-67 and angiogenesis assessed by VEGF in tubal pregnancy.
PMID: 24523985 [PubMed] (Source: Pathology Research International)
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Mycobacterium genavense Infections in a Tertiary Hospital and Reviewed Cases in Non-HIV Patients.
We describe clinical and laboratory features and response to therapy in 7 patients, three of them with HIV infection and four non-HIV-three organ transplant recipients and one with hyper-IgE syndrome-in Valencia, Spain, in a ten years period. We then summarize the published cases of M. avium complex infection, with invasion of peripheral blood, liver, spleen, bone marrow, lymph nodes, and lungs. In clinical samples a large number of acid-fast bacilli were observed. M. genavense grew only from liquid media and after a prolonged incubation period. Its identification was accomplished through molecular methods. Patients were t...
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Assessment of tissue eosinophilia as a prognosticator in oral epithelial dysplasia and oral squamous cell carcinoma-an image analysis study.
Authors: Jain M, Kasetty S, Sudheendra US, Tijare M, Khan S, Desai A
Abstract
Association of tissue eosinophilia with oral squamous cell carcinoma has shown variable results ranging from favourable to unfavourable or even having no influence on prognosis. Also, very few studies have been done to know the role of eosinophils in premalignancy. So the present study investigated role of eosinophilic infiltration in oral precancer and cancer and its possible use as a prognosticator. 60 histopathologically proven cases (20 cases each of metastatic and nonmetastatic oral squamous cell carcinoma and oral leukoplak...
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
Study assessing the quality of quantification of estrogen receptor protein expression by immunohistochemistry and gene expression in breast cancer.
This study aims to investigate the influences of preanalytical and analytical factors on IHC results. For this purpose, the different steps of the preparation of IHC sections and scoring procedures were compared between two participating laboratories and a central lab. There was a significant positive correlation between the IHC results of the participating laboratories and those of the central lab (correlation coefficient > 0.600; P<0.05). Nevertheless, some discordant cases for immunostaining (5.3% for ER and 5.6% for PR) and for scoring (10.5% for PR) occur at site 1. Comparing IHC results with ESR1 gene expressio...
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
A cytological study of palpable superficial nodules of parasitic origin: a study of 41 cases.
Conclusion. Careful assessment of cytological material is helpful to detect parasite or inflammatory response to parasite even in asymptomatic patients.
PMID: 24757574 [PubMed] (Source: Pathology Research International)
Source: Pathology Research International - December 2, 2014 Category: Pathology Tags: Patholog Res Int Source Type: research
