Simple and rapid radiosynthesis of N-18F-Labeled glutamic acid as a hepatocellular carcinoma PET tracer
The objectives of this study are to synthesize 18F–FPGLU via a two-step reac tion sequence and to evaluate the value of 18F–FPGLU in nude mice bearing human hepatocellular carcinoma SMCC-7721 (HCC SMCC-7721). (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - March 2, 2017 Category: Nuclear Medicine Authors: Aixia Sun, Shaoyu Liu, Xiaolan Tang, Dahong Nie, Ganghua Tang, Zhanwen Zhang, Fuhua Wen, Xiaoyan Wang Source Type: research
Preparation and evaluation of Rhenium-188-Pamidronate as a palliative treatment in bone metastasis
Rhenium-188-hydroxyethylidene diphosphonate (188Re-HEDP) as a first generation bisphosphonate has been widely used for bone seeking radiopharmaceutical in cases of metastatic bone disease. No study has been yet reported on preparing a complex of 188Re with pamidronate (3-aminohydroxypropylidene-1,1-bisphosphonic acid) (PMA) as a second generation bisphosphonate. Based on this fact, it was hypothesized that a bone-seeking 188Re-PMA radiopharmaceutical could be developed as an agent for palliative radiotherapy of bone pain due to skeletal metastases. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - February 23, 2017 Category: Nuclear Medicine Authors: Mostafa Erfani, Nasim Rahmani, Alireza Doroudi, mohammad Shafiei Source Type: research
Effect of methoxy group position on biological properties of 18F –labeled benzyl triphenylphosphonium cations
18F –labeled phosphonium cations targeting mitochondrial membrane potential would be promising for positron emission tomography (PET) myocardial perfusion imaging (MPI). The purpose of this study was to examine the influence of additional methoxy group and its different positions on myocardium uptake and pharmacokinetics properties of 18F–labeled benzyl triphenylphosphonium cations. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - February 23, 2017 Category: Nuclear Medicine Authors: Shuting Chen, Zuoquan Zhao, Ying Zhang, Wei Fang, Jie Lu, Xianzhong Zhang Source Type: research
Gefitinib enhances radiotherapeutic effects of 131I –hEGF targeted to EGFR by increasing tumor uptake of hEGF in tumor xenografts
In this study, we sought to determine whether gefitinib could increase the in vivo tumor uptake of human 131I –EGF (131I–hEGF), thereby enhancing the potential of hEGF as a vehicle for EGFR-targeted radionuclide therapy. Western blot analysis was conducted to detect the effects of gefitinib on EGFR expression in human head and neck squamous carcinoma cell line UM-SCC-22B. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - February 3, 2017 Category: Nuclear Medicine Authors: Lu Xia, He Peng, Luo Zhiqiang, Zhang Xiaoli Source Type: research
Clinical translation of a PSMA inhibitor for 99mTc-based SPECT
Prostate-specific membrane antigen (PSMA) is highly over-expressed in advanced prostate cancers. 68Ga-labeled PSMA inhibitors (iPSMA) are currently used for prostate cancer detection by PET imaging. The availability of simple, efficient and reproducible radiolabeling procedures is essential for developing new SPECT radiopharmaceuticals for clinical translation. The aim of this research was to prepare 99mTc-EDDA/HYNIC-Lys(Nal)-Urea-Glu (99mTc-EDDA/HYNIC-iPSMA) obtained from lyophilized kit formulations and evaluate the in vitro and in vivo radiopharmaceutical binding to prostate cancer cells over-expressing PSMA, as well as...
Source: Nuclear Medicine and Biology - February 2, 2017 Category: Nuclear Medicine Authors: Guillermina Ferro-Flores, Myrna Luna-Guti érrez, Blanca Ocampo-García, Clara Santos-Cuevas, Erika Azorín-Vega, Nallely Jiménez-Mancilla, Emmanuel Orocio-Rodríguez, Jenny Davanzo, Francisco O. García-Pérez Source Type: research
Development of a preclinical 211Rn/211At generator system for targeted alpha therapy research with 211At
This study demonstrated the feasibility of using generator-produced 211At to label monoclonal antibody (BC8, anti-human CD45) for preclinical use, following isolation from the 207Po contamination also produced by these generators (by 211Rn α-decay). (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - January 28, 2017 Category: Nuclear Medicine Authors: Jason R Crawford, Hua Yang, Peter Kunz, D Scott Wilbur, Paul Schaffer, Thomas J Ruth Source Type: research
99mTc-labeling and evaluation of a HYNIC modified small-molecular inhibitor of prostate-specific membrane antigen
In this study, we evaluated a novel 99mTc-labeled small molecular inhibitor of PSMA. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - January 27, 2017 Category: Nuclear Medicine Authors: Xiaoping Xu, Jianping Zhang, Simin He, Xiao Bao, Guang Ma, Jianmin Luo, Silong Hu, Jingyi Cheng, Yingjian Zhang Source Type: research
Relationship between [14C]MeAIB uptake and amino acid transporter family gene expression levels or proliferative activity in a pilot study in human carcinoma cells: comparison with [3H]Methionine uptake
To clarify the difference between system A and L amino acid transport imaging in PET clinical imaging, we focused on the use of α-[N-methyl-11C]-methylaminoisobutyric acid ([11C]MeAIB), and compared it with [S-methyl-11C]-L-methionine ([11C]MET). The aim of this study was to assess the correlation of accumulation of these two radioactive amino acid analogs with expression of amino acid transporters and cell proliferative ac tivity in carcinoma cells. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - January 24, 2017 Category: Nuclear Medicine Authors: Shinya Kagawa, Ryuichi Nishii, Tatsuya Higashi, Hiroshi Yamauchi, Emi Ogawa, Hiroyuki Okudaira, Masato Kobayashi, Mitsuyoshi Yoshimoto, Naoto Shikano, Keiichi Kawai Source Type: research
Monitoring of macrophage accumulation in statin-treated atherosclerotic mouse model using sodium iodide symporter imaging system
Macrophages play a key role in atherosclerotic plaque formation in atherosclerosis, but its detailed understanding has poorly investigated until now. Thus, we sought to demonstrate a noninvasive technique for macrophage tracking to atherosclerotic lesions in apolipoprotein E −/−(ApoE−/−) mice with an imaging system based on sodium iodide symporter (NIS) gene coupled with 99mTc-single-photon emission computed tomography (SPECT).Methods and Results.Macrophage cells (RAW264.7) were stably transduced with retrovirus expressing NIS gene (RAW-NIS). (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - January 24, 2017 Category: Nuclear Medicine Authors: Ran Ji Yoo, Min Hwan Kim, Sang-Keun Woo, Kwang Il Kim, Tae Sup Lee, Yang-Kyu Choi, Joo Hyun Kang, Sang Moo Lim, Yong Jin Lee Source Type: research
Iminodiacetic Acid as Bifunctional Linker for Dimerization of Cyclic RGD Peptides
In this study, I2P –RGD2 was used as the example to illustrate a novel approach for dimerization of cyclic RGD peptides. The main objective of this study was to explore the impact of bifunctional linkers (glutamic acid vs. iminodiacetic acid) on tumor-targeting capability and excretion kinetics of the 99mTc-labeled dimeric cyclic RGD peptides. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - January 18, 2017 Category: Nuclear Medicine Authors: Dong Xu, Zuo-Quan Zhao, Shu-Ting Chen, Yong Yang, Wei Fang, Shuang Liu Source Type: research
Redesign of negatively charged 111In-DTPA-octreotide derivative to reduce renal radioactivity
Radiolabeled octreotide derivatives have been studied as diagnostic and therapeutic agents for somatostatin receptor-positive tumors. To prevent unnecessary radiation exposure during their clinical application, the present study aimed to develop radiolabeled peptides which could reduce radioactivity levels in the kidney at both early and late post-injection time points by introducing a negative charge with an acidic amino acid such as L-aspartic acid (Asp) at a suitable position in 111In-DTPA-conjugated octreotide derivatives. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - January 16, 2017 Category: Nuclear Medicine Authors: Nobuhiro Oshima, Hiromichi Akizawa, Hidekazu Kawashima, Songji Zhao, Yan Zhao, Ken-ichi Nishijima, Yoji Kitamura, Yasushi Arano, Yuji Kuge, Kazue Ohkura Source Type: research
18F-fluoro-2-deoxyglucose PET informs neutrophil accumulation and activation in lipopolysaccharide-induced acute lung injury
Molecular imaging of the earliest events related to the development of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) could facilitate therapeutic development and patient management. We previously reported that 18F-fluoro-2-deoxyglucose (18F-FDG) PET identifies ALI/ARDS prior to radiographic abnormalities. The purpose of this study was to establish the time courses of 18F-FDG uptake, edema and neutrophil recruitment in an endotoxin-induced acute lung injury model and to examine molecular events required for 14C-2DG uptake in activated neutrophils. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - January 15, 2017 Category: Nuclear Medicine Authors: Rosana S. Rodrigues, Fernando A. Bozza, Christopher J. Hanrahan, Li-Ming Wang, Qi Wu, John M. Hoffman, Guy A. Zimmerman, Kathryn A. Morton Source Type: research
PET Imaging of 64Cu-DOTA-scFv-Anti-PSMA Lipid Nanoparticles (LNPs): Enhanced Tumor Targeting over Anti-PSMA scFv or Untargeted LNPs
Single chain (scFv) antibodies are ideal targeting ligands due to their modular structure, high antigen specificity and affinity. These monovalent ligands display rapid tumor targeting but have limitations due to their fast urinary clearance. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - January 15, 2017 Category: Nuclear Medicine Authors: Patty Wong, Lin Li, Junie Chea, Melissa K. Delgado, Desiree Crow, Erasmus Poku, Barbara Szpikowska, Nicole Bowles, Divya Channappa, David Colcher, Jeffrey Y.C. Wong, John E. Shively, Paul J. Yazaki Source Type: research
18F –Fluoro-2-deoxyglucose PET informs neutrophil accumulation and activation in lipopolysaccharide-induced acute lung injury
Molecular imaging of the earliest events related to the development of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) could facilitate therapeutic development and patient management. We previously reported that 18F –fluoro-2-deoxyglucose (18F–FDG) PET identifies ALI/ARDS prior to radiographic abnormalities. The purpose of this study was to establish the time courses of 18F–FDG uptake, edema and neutrophil recruitment in an endotoxin-induced acute lung injury model and to examine molecular events required for 14C-2DG uptake in activated neutrophils. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - January 15, 2017 Category: Nuclear Medicine Authors: Rosana S. Rodrigues, Fernando A. Bozza, Christopher J. Hanrahan, Li-Ming Wang, Qi Wu, John M. Hoffman, Guy A. Zimmerman, Kathryn A. Morton Source Type: research
Evaluation of [18F]-ATRi as PET tracer for in vivo imaging of ATR in mouse models of brain cancer
Ataxia telangiectasia and Rad3-related (ATR) threonine serine kinase is one of the key elements in orchestrating the DNA damage response (DDR). As such, inhibition of ATR can amplify the effects of chemo- and radiation-therapy, and several ATR inhibitors (ATRi) have already undergone clinical testing in cancer. For more accurate patient selection, monitoring and staging, real-time in vivo imaging of ATR could be invaluable; the development of appropriate imaging agents has remained a major challenge. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - January 13, 2017 Category: Nuclear Medicine Authors: Giuseppe Carlucci, Brandon Carney, Ahmad Sadique, Axel Vansteene, Jun Tang, Thomas Reiner Source Type: research
