Table of Contents
(Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - June 21, 2017 Category: Nuclear Medicine Source Type: research
Whole-body biodistribution of the cannabinoid type 1 receptor ligand [18F]MK-9470 in the rat
The endocannabinoid system participates in many processes in the body, including memory, reward, pain, motor activity, food intake, energy metabolism, and gastrointestinal functions. [18F]MK-9470 is a positron emission tomography (PET) ligand that binds with high affinity and selectivity to the cannabinoid type 1 receptor. In order to fully characterize ligand behavior, tracer uptake measured using in vivo microPET was compared with results from ex vivo tissue dissection.Twelve male Sprague-Dawley rats were divided into three subgroups and scanned over time periods of 10 min, 30 min and 90 min using PET. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - June 15, 2017 Category: Nuclear Medicine Authors: H.G. Buchholz, K. Uebbing, S. Maus, S. Pektor, N. Afahaene, V. Weyer-Elberich, B. Lutz, M. Schreckenberger, I. Miederer Source Type: research
Developing new PET tracers to image the growth hormone secretagogue receptor 1a (GHS-R1a)
In this study, we developed three new PET tracers for GHS-R1a: 18F –labeled 6-(4-chlorophenyl)-3-((1-(2-fluoroethyl)piperidin-3-yl)methyl)-2-(o-tolyl)quinazolin-4(3H)-one (1), 11C–labeled 6-(4-chlorophenyl)-3-((1-(2-methoxyethyl)piperidin-3-yl)methyl)-2-(o-tolyl)quinazolin-4(3H)-one (2), and 11C–labeled (S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(4′ -methoxy-[1,1′-biphenyl]-4-yl)methanone (3). (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - June 10, 2017 Category: Nuclear Medicine Authors: Kazunori Kawamura, Masayuki Fujinaga, Yoko Shimoda, Tomoteru Yamasaki, Yiding Zhang, Akiko Hatori, Lin Xie, Hidekatsu Wakizaka, Katsushi Kumata, Takayuki Ohkubo, Yusuke Kurihara, Masanao Ogawa, Nobuki Nengaki, Ming-Rong Zhang Source Type: research
Amide-to-Triazole Switch vs. In Vivo NEP-Inhibition Approaches to Promote Radiopeptide Targeting of GRPR-Positive Tumors
Radiolabeled bombesin (BBN)-analogs have been proposed for diagnosis and therapy of gastrin-releasing peptide receptor (GRPR)-expressing tumors, such as prostate, breast and lung cancer. Metabolic stability represents a crucial factor for the success of this approach by ensuring sufficient delivery of circulating radioligand to tumor sites. The amide-to-triazole switch on the backbone of DOTA-PEG4-[Nle14]BBN(7 –14) (1) was reported to improve the in vitro stability of resulting 177Lu-radioligands. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - June 10, 2017 Category: Nuclear Medicine Authors: Theodosia Maina, Aikaterini Kaloudi, Ibai E. Valverde, Thomas L. Mindt, Berthold A. Nock Source Type: research
A Simple Device to Convert a Small-Animal PET Scanner into a Multi-Sample Tissue and Injection Syringe Counter
We describe a simple fixture that can be added to the imaging bed of a small-animal PET scanner that allows automated counting of multiple organ or tissue samples from mouse-sized animals and counting of injection syringes prior to administration of the radiotracer. The combination of imaging and counting capabilities in the same machine offers advantages in certain experimental settings. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - June 3, 2017 Category: Nuclear Medicine Authors: Michael V. Green, Jurgen Seidel, Peter L. Choyke, Elaine M. Jagoda Source Type: research
Dose-on-demand production of diverse 18F-radiotracers for preclinical applications using a continuous flow microfluidic system
We describe the dose-on-demand principle, whereby the back-to-back production of multiple, diverse 18F-radiotracers can be prepared on the same day, on the same microfluidic system using the same batch of [18F]fluoride, the same microreactor, the same HPLC column and SPE cartridge to obtain a useful production yield. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - June 2, 2017 Category: Nuclear Medicine Authors: Lidia Matesic, Annukka Kallinen, Ivan Greguric, Giancarlo Pascali Source Type: research
Dose-on-demand production of diverse 18F –radiotracers for preclinical applications using a continuous flow microfluidic system
We describe the dose-on-demand principle, whereby the back-to-back production of multiple, diverse 18F–radiotracers can be prepared on the same day, on the same microfluidic system using t he same batch of [18F]fluoride, the same microreactor, the same HPLC column and SPE cartridge to obtain a useful production yield. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - June 2, 2017 Category: Nuclear Medicine Authors: Lidia Matesic, Annukka Kallinen, Ivan Greguric, Giancarlo Pascali Source Type: research
Evaluation of a novel radiotracer for positron emission tomography imaging of reactive oxygen species in the central nervous system
We describe here the radiosynthesis and initial ex vivo and in vivo evaluation of [11C]hydromethidine ([11C]HM) as a radiotracer to image ROS using positron emission tomography (PET). (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - June 1, 2017 Category: Nuclear Medicine Authors: Alan A. Wilson, Oleg Sadovski, Jos é N. Nobrega, Roger J. Raymond, Francis R. Bambico, Mina G. Nashed, Armando Garcia, Peter M. Bloomfield, Sylvain Houle, Romina Mizrahi, Junchao Tong Source Type: research
67Ga-labeled deferoxamine derivatives for imaging bacterial infection: Preparation and screening of functionalized siderophore complexes
Deferoxamine (DFO) is a siderophore that bacteria use to scavenge iron and could serve as a targeting vector to image bacterial infection where current techniques have critical limitations. [67Ga]-DFO, which is a mimetic of the corresponding iron complex, is taken up by bacteria in culture, however in vivo it clears too rapidly to allow for imaging of infection. In response, we developed several new DFO derivatives to identify those that accumulate in bacteria, and at sites of infection, and that could potentially have improved pharmacokinetics. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - May 31, 2017 Category: Nuclear Medicine Authors: Joseph A. Ioppolo, Deanna Caldwell, Omid Beiraghi, Lisset Llano, Megan Blacker, John F. Valliant, Paul J. Berti Source Type: research
67Ga-labelled deferoxamine derivatives for imaging bacterial infection: Preparation and screening of functionalized siderophore complexes
Deferoxamine (DFO) is a siderophore that bacteria use to scavenge iron and could serve as a targeting vector to image bacterial infection where current techniques have critical limitations. [67Ga]-DFO, which is a mimetic of the corresponding iron complex, is taken up by bacteria in culture, however in vivo it clears too rapidly to allow for imaging of infection. In response, we developed several new DFO derivatives to identify those that accumulate in bacteria, and at sites of infection, and that could potentially have improved pharmacokinetics. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - May 31, 2017 Category: Nuclear Medicine Authors: Joseph A. Ioppolo, Deanna Caldwell, Omid Beiraghi, Lisset Llano, Megan Blacker, John F. Valliant, Paul J. Berti Source Type: research
Neutron-Activatable Radionuclide Cancer Therapy Using Graphene Oxide Nanoplatelets
Neutron-activation is a promising method of generating radiotherapeutics with minimal handling of radioactive materials. Graphene oxide nanoplatelets (GONs) were examined as a carrier for neutron-activatable holmium with the purpose of exploiting inherent characteristics for theranostic application. GONs were hypothesized to be an ideal candidate for this application owing to their desirable characteristics such as a rigid structure, high metal loading capacity, low density, heat resistance, and the ability to withstand harsh environments associated with the neutron-activation process. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - May 31, 2017 Category: Nuclear Medicine Authors: Junghyun Kim, Michael Jay Tags: Research Paper Source Type: research
Editorial Board
(Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - May 30, 2017 Category: Nuclear Medicine Source Type: research
Table of Contents
(Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - May 30, 2017 Category: Nuclear Medicine Source Type: research
211At labeled substance P (5 –11) as potential radiopharmaceutical for glioma treatment
The purposes of the present work were to label substance P (5 –11) with 211At using a rhodium(III) complex with a bifunctional ligand–2-(1,5,9,13-tetrathiacyclohexadecan-3-yloxy)acetic acid ([16aneS4]-COOH) and to assess the in vitro stability and toxicity of the obtained radiobioconjugate. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - May 25, 2017 Category: Nuclear Medicine Authors: Monika Lyczko, Marek Pruszynski, Agnieszka Majkowska-Pilip, Krzysztof Lyczko, Bogdan Was, Sylwia Meczynska-Wielgosz, Marcin Kruszewski, Katarzyna Szkliniarz, Jerzy Jastrzebski, Anna Stolarz, Aleksander Bilewicz Source Type: research
131I-labeled chitosan hydrogels for radioembolization: A preclinical study in small animals
The purpose of the study was to examine potential of 131I-labeled chitosan hydrogels (Chi) for treatment of liver cancer. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - May 25, 2017 Category: Nuclear Medicine Authors: Hyosook Hwang, Kwang Il Kim, JeongIl Kwon, Byoung Soo Kim, Hwan-Seok Jeong, Su Jin Jang, Phil-Sun Oh, Ho Sung Park, Seok Tae Lim, Myung-Hee Sohn, Hwan-Jeong Jeong Source Type: research
