Developing new PET tracers to image the growth hormone secretagogue receptor 1a (GHS-R1a)
In this study, we developed three new PET tracers for GHS-R1a: 18F –labeled 6-(4-chlorophenyl)-3-((1-(2-fluoroethyl)piperidin-3-yl)methyl)-2-(o-tolyl)quinazolin-4(3H)-one (1), 11C–labeled 6-(4-chlorophenyl)-3-((1-(2-methoxyethyl)piperidin-3-yl)methyl)-2-(o-tolyl)quinazolin-4(3H)-one (2), and 11C–labeled (S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(4′ -methoxy-[1,1′-biphenyl]-4-yl)methanone (3).
Source: Nuclear Medicine and Biology - Category: Nuclear Medicine Authors: Kazunori Kawamura, Masayuki Fujinaga, Yoko Shimoda, Tomoteru Yamasaki, Yiding Zhang, Akiko Hatori, Lin Xie, Hidekatsu Wakizaka, Katsushi Kumata, Takayuki Ohkubo, Yusuke Kurihara, Masanao Ogawa, Nobuki Nengaki, Ming-Rong Zhang Source Type: research
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