PET/CT with 18F –choline: physiological whole bio-distribution in male and female subjects and diagnostic pitfalls on 1000 prostate cancer patients
The 11C/18F –choline is a PET/CT radiopharmaceutical useful in detecting tumors with high lipogenesis. 11C/18F–choline uptake can occurs in physiological conditions or tumors. The knowledge of its bio-distribution is essential to recognize physiologic variants or diagnostic pitfalls. Moreover, few informati on are available on the bio-distribution of this tracer in female patients. Our aim was to discuss some documented 18F–choline PET/CT pitfalls in prostate cancer patients. Our secondary aim was to describe the 18F–choline bio-distribution in the female body. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - April 17, 2017 Category: Nuclear Medicine Authors: Ferdinando Calabria, Agostino Chiaravalloti, Carmelo Cicci ò, Vincenzo Gangemi, Domenico Gullà, Federico Rocca, Gianpasquale Gallo, Giuseppe Lucio Cascini, Orazio Schillaci Source Type: research
Clinical usefulness of 18F –FDG PET/CT for initial staging and assessment of treatment efficacy in patients with lymph node tuberculosis
Few studies have evaluated the promising role of 18F –fluoro-2-deoxy-D-glucose positron emission tomography (PET) and PET/computed tomography FDG PET/CT in evaluating and monitoring treatment response in patients with lymph node tuberculosis (LNTB). The aim of this clinical investigation was to assess the clinical usefulness of FDG PET/CT for initia l tuberculosis staging and to dertermine the prognostic value of the decrease of 18F–FDG uptake during antibiotic treatment in LNTB patients. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - April 8, 2017 Category: Nuclear Medicine Authors: Lefebvre Nicolas, Argemi Xavier, Meyer Nicolas, Mootien Joy, Douiri Nawal, Sferrazza-Mandala Stefania, Schramm Fr édéric, Weingertner Noëlle, Christmann Daniel, Hansmann Yves, Imperiale Alessio Source Type: research
Proton-induced production and radiochemical isolation of 44Ti from scandium metal targets for 44Ti/44Sc generator development
Scandium-44g (half-life 3.97h) shows promise for application in positron emission tomography (PET), due to favorable decay parameters. One of the sources of 44gSc is the 44Ti/44gSc generator, which can conveniently provide this radioisotope on a daily basis at a diagnostic facility. Titanium-44 (half-life 60.0 a), in turn, can be obtained via proton irradiation of scandium metal targets. A substantial 44Ti product batch, however, requires high beam currents, long irradiation times and an elaborate chemical procedure for 44Ti isolation and purification. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - April 7, 2017 Category: Nuclear Medicine Authors: Valery Radchenko, Jonathan W. Engle, Dmitri G. Medvedev, Joel M. Maassen, Cleo M. Naranjo, George A. Unc, Catherine A.L. Meyer, Tara Mastren, Mark Brugh, Leonard Mausner, Cathy S. Cutler, Eva R. Birnbaum, Kevin D. John, F. Meiring Nortier, Michael E. Fass Source Type: research
Detection of melanoma metastases with PET —comparison of 18F-5-FPN with 18F–FDG
18F-5-fluoro-N-(2-(Diethylamino)ethyl)picolinamide (18F-5-FPN) is a new positron-emission tomography (PET) radiopharmaceutical with potential for the detection of lymph node (LN) and pulmonary metastatic lesions of melanoma. We compared its performance with that of 18F –deoxyglucose (18F–FDG). (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - April 7, 2017 Category: Nuclear Medicine Authors: Yichun Wang, Mengting Li, Yingying Zhang, Fengzhen Zhang, Chunbao Liu, Yiling Song, Yongxue Zhang, Xiaoli Lan Source Type: research
Proton induced production and radiochemical isolation of 44Ti from scandium metal targets for 44Ti/44Sc generator development
Scandium-44g (half-life 3.97h) shows promise for application in Positron Emission Tomography (PET), due to favorable decay parameters. One of the sources of 44gSc is the 44Ti/44gSc generator, which can conveniently provide this radioisotope on a daily basis at a diagnostic facility. Titanium-44 (half-life 60.0 a), in turn, can be obtained via proton irradiation of scandium metal targets. A substantial 44Ti product batch, however, requires high beam currents, long irradiation times and an elaborate chemical procedure for 44Ti isolation and purification. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - April 7, 2017 Category: Nuclear Medicine Authors: Valery Radchenko, Jonathan W. Engle, Dmitri G. Medvedev, Joel M. Maassen, Cleo M. Naranjo, George A. Unc, Catherine A.L. Meyer, Tara Mastren, Mark Brugh, Leonard Mausner, Cathy S. Cutler, Eva R. Birnbaum, Kevin D. John, F. Meiring Nortier, Michael E. Fass Source Type: research
Radiosynthesis and biological evaluation of N-(2-[18F]Fluoropropionyl)-3,4-dihydroxy-L-phenylalanine as a PET tracer for oncologic imaging
Several 11C and 18F labelled 3,4-dihydroxy-L-phenylalanine (L-DOPA) analogues have been used for neurologic and oncologic diseases, especially for brain tumors and neuroendocrine tumors PET imaging. However, 18F –labeled N-substituted L-DOPA analogues have not been reported so far. In the current study, radiosynthesis and biological evaluation of a new 18F–labeled L-DOPA analogue, N-(2-[18F]Fluoropropionyl)-3,4-dihydroxy-L-phenylalanine ([18F]FPDOPA) for tumor PET imaging are performed. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - April 7, 2017 Category: Nuclear Medicine Authors: Caihua Tang, Dahong Nie, Ganghua Tang, Siyuan Gao, Shaoyu Liu, Fuhua Wen, Xiaolan Tang Source Type: research
Clinical results and economic considerations of 68Ga-PSMA and radiolabeled choline in prostate cancer
In recent years there was an impressive improvement in the options for the management of patients with prostate cancer. Nuclear Medicine has significantly enriched its diagnostic options, both in radiopharmacy and in instrumentation, in order to accurately target prostatic cancer cells, thus rendering the physicians able to adopt the best therapeutic strategy. In the present analysis, we have evaluated the available published data about 68Ga-PSMA and radio-labeled choline, two radiopharmaceutical agents for positron emission tomography/computed tomography (PET/CT) examination, by reporting clinical information and consider...
Source: Nuclear Medicine and Biology - April 4, 2017 Category: Nuclear Medicine Authors: Laura Evangelista, Maria Giuseppina Bonavina, Emilio Bombardieri Tags: Clinical perspectives Source Type: research
Clinical results and economic considerations of 68ga-psma and radiolabelled choline in prostate cancer
In the recent years there was an impressive improvement in the options for the management of patients with prostate cancer. Nuclear Medicine has significantly enriched its diagnostic options, both in radiopharmacy and in instrumentation, in order to accurately target prostatic cancer cells, thus rendering the physicians able to adopt the best therapeutic strategy. In the present analysis, we have evaluated the available published data about 68Ga-PSMA and radio-labelled choline, two radiopharmaceutical agents for positron emission tomography/computed tomography (PET/CT) examination, by reporting clinical information and con...
Source: Nuclear Medicine and Biology - April 4, 2017 Category: Nuclear Medicine Authors: Laura Evangelista, Maria Giuseppina Bonavina, Emilio Bombardieri Tags: Clinical perspectives Source Type: research
Production of Zr-89 using sputtered yttrium coin targets
An increasing interest in zirconium-89 (89Zr) can be attributed to the isotope's half-life which is compatible with antibody imaging using positron emission tomography (PET). The goal of this work was to develop an efficient means of production for 89Zr that provides this isotope with high radionuclidic purity and specific activity. We investigated the irradiation of yttrium sputtered niobium coins and compared the yields and separation efficiency to solid yttrium coins. The sputtered coins were irradiated with an incident beam energy of 17.5MeV or 17.8MeV providing a degraded transmitted energy through an aluminum degrade...
Source: Nuclear Medicine and Biology - March 23, 2017 Category: Nuclear Medicine Authors: Stacy Lee Queern, Tolulope Aramide Aweda, Adriana Vidal Fernandes Massicano, Nicholas Ashby Clanton, Retta El Sayed, Jayden Andrew Sader, Alexander Zyuzin, Suzanne Elizabeth Lapi Source Type: research
Production of Zr-89 using sputtered yttrium coin targets 89Zr using sputtered yttrium coin targets
An increasing interest in zirconium-89 (89Zr) can be attributed to the isotope's half-life which is compatible with antibody imaging using positron emission tomography (PET). The goal of this work was to develop an efficient means of production for 89Zr that provides this isotope with high radionuclidic purity and specific activity. We investigated the irradiation of yttrium sputtered niobium coins and compared the yields and separation efficiency to solid yttrium coins. The sputtered coins were irradiated with an incident beam energy of 17.5MeV or 17.8MeV providing a degraded transmitted energy through an aluminum degrade...
Source: Nuclear Medicine and Biology - March 23, 2017 Category: Nuclear Medicine Authors: S.L. Queern, T.A. Aweda, A.V.F. Massicano, N.A. Clanton, R. El Sayed, J.A. Sader, A. Zyuzin, S.E. Lapi Source Type: research
LogP, a yesterday's value?
There is an increasing demand for high throughput methods at early stages of preclinical radioligand development, in order to predict pharmacokinetic properties (e.g. biodistribution) and blood brain barrier (BBB) penetration. One of the most important physicochemical properties is the lipophilicity, measured by means of shake-flask (logP) or HPLC methods. Yet, a plethora of experimental methods are described in literature for the determination of logP values. These varying methods often lead to different results for one identical compound, which complicates any comparison or prediction for subsequent preclinical studies. ...
Source: Nuclear Medicine and Biology - March 19, 2017 Category: Nuclear Medicine Authors: Chrysoula Vraka, Lukas Nics, Karl-Heinz Wagner, Marcus Hacker, Wolfgang Wadsak, Markus Mitterhauser Source Type: research
Pancreas and liver uptake of new radiolabeled incretins (GLP-1 and Exendin-4) in models of diet-induced and diet-restricted obesity
Radiolabeled GLP-1 and its analog Exendin-4, have been employed in diabetes and insulinoma. No protocol in conventional Diet-Induced Obesity (DIO), and Diet-Restricted Obesity (DRO), has been identified. Aiming to assess pancreatic beta cell uptake in DIO and DRO, a protocol was designed. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - March 17, 2017 Category: Nuclear Medicine Authors: Daniele Seo, Bluma Linkowski Faintuch, Erica Aparecida de Oliveira, Joel Faintuch Source Type: research
Contribution of neuroinflammation to changes in [11C]flumazenil binding in the rat brain: evaluation of the inflamed pons as reference tissue
This study aims to evaluate whether inflammatory processes in the brain can influence [11C]flumazenil uptake and affect the outcome of pharmacokinetic modeling when the pons is used as reference tissue. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - March 17, 2017 Category: Nuclear Medicine Authors: Andrea Parente, David V állez García, Alexandre Shoji, Isadora Lopes Alves, Bram Maas, Rolf Zijlma, Rudi AJO Dierckx, Carlos A Buchpiguel, Erik FJ de Vries, Janine Doorduin Source Type: research
99mTc-3PRGD2 scintigraphy to stage liver fibrosis and evaluate reversal after fibrotic stimulus withdrawn
Today, it is well accepted that partial or complete regression of liver fibrosis and even cirrhosis can be potentially achieved if the underlying etiology of the disease is suppressed or the anti-fibrotic strategies employed are effective [1,2]. Accurate evaluation of liver fibrosis severity is critical for developing a timely treatment plan that may prevent or postpone fibrotic progression, or even reverse fibrogenesis [3]. To date, the histological examination of a liver biopsy (LB) specimen remains the “gold standard” for clinically evaluating the severity of liver fibrosis. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - March 6, 2017 Category: Nuclear Medicine Authors: Xin Zhang, Qiyong Guo, Yu Shi, Weina Xu, Shupeng Yu, Zhiguang Yang, Li Cao, Changping Liu, Zhoushe Zhao, Jun Xin Source Type: research
Excitation function and yield for the 103Rh(d,2n)103Pd nuclear reaction: optimization of the production of palladium-103
Deuteron-induced nuclear reactions for the generation of 103Pd were investigated using the stacked-foil activation technique on rhodium targets at deuteron energies up to Ed = 33 MeV. The excitation functions of the reactions 103Rh(d,xn)101,103Pd, 103Rh(d,x)100g,cum,101m,g,102m,gRh and 103Rh(d,2p)103Ru have been measured, and the Thick-Target Yield for 103Pd has been calculated. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - March 4, 2017 Category: Nuclear Medicine Authors: Simone Manenti, Mar ía del Carmen Alí Santoro, Giulio Cotogno, Charlotte Duchemin, Ferid Haddad, Uwe Holzwarth, Flavia Groppi Source Type: research
