Editorial Board
(Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - September 1, 2018 Category: Nuclear Medicine Source Type: research
Table of Contents
(Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - September 1, 2018 Category: Nuclear Medicine Source Type: research
Assessing the feasibility of intranasal radiotracer administration for in brain PET imaging
The development of clinically useful tracers for PET imaging is enormously challenging and expensive. The intranasal (IN) route of administration is purported to be a viable route for delivering drugs to the brain but has, as yet, not been investigated for the delivery of PET tracers. If the intranasal (IN) pathway presents a viable option, it extends the PET imaging field by increasing the number of tracers available for human use.Here we report the results of a rodent study testing the feasibility of the IN route to administer radiotracers for brain PET imaging. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - August 29, 2018 Category: Nuclear Medicine Authors: Nisha Singh, Mattia Veronese, Jim O'Doherty, Teresa Sementa, Salvatore Bongarzone, Diana Cash, Camilla Simmons, Marco Arcolin, Paul Marsden, Antony Gee, Federico E. Turkheimer Source Type: research
Dynamic TSPO-PET for assessing early effects of cerebral hypoxia and resuscitation in new born pigs
Inflammation associated with microglial activation may be an early prognostic indicator of perinatal hypoxic ischemic injury, where translocator protein (TSPO) is a known inflammatory biomarker. This piglet study used dynamic TSPO-PET with [18F]GE180 to evaluate if microglial activation after global perinatal hypoxic injury could be detected. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - August 24, 2018 Category: Nuclear Medicine Authors: Charlotte de Lange, R ønnaug Solberg, Jon Erik Holtedahl, Andreas Tulipan, Jon Barlinn, William Trigg, Torild Wickstrøm, Ola Didrik Saugstad, Eirik Malinen, Mona Elisabeth Revheim Source Type: research
Preliminary evaluation of a novel 18F-labeled PARP-1 ligand for PET imaging of PARP-1 expression in prostate cancer
Poly (ADP-ribose) polymerase-1 (PARP-1) plays many roles in prostate cancer (PC), such as mediating DNA damage repair, transcriptional regulation and nuclear hormone receptor signaling. Because of this, PARP-1 has been targeted for therapy in PC, and non-invasive imaging of PARP-1 could help predict which patients are likely to respond to such therapy. Several PARP-1 positron emission tomography (PET) imaging agents have been developed and show promise for imaging PARP-1 expression in breast, brain, and lung cancer in small animals, but not as yet in prostate cancer. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - August 24, 2018 Category: Nuclear Medicine Authors: Dong Zhou, Jinbin Xu, Cedric Mpoy, Wenhua Chu, Sung Hoon Kim, Huifangjie Li, Buck E. Rogers, John A. Katzenellenbogen Source Type: research
Synthesis and evaluation of an N-[18F]fluorodeoxyglycosyl amino acid for PET imaging of tumor metabolism
The limitations of [18F]fluorodeoxyglucose (18F]FDG), including producing false-positive or -negative results, low image contrast in brain tumor diagnosis and poor differentiation of tumor and inflammatory, necessitate the development of amino acid based radiopharmaceuticals. In the present study, a novel [18F]fluoroglycoconjugate tracer, [18F]FDGly-NH-Phe, for tumor metabolism imaging was prepared and evaluated. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - August 15, 2018 Category: Nuclear Medicine Authors: Zhifang Wu, Jingxin Ma, Anna-liisa Brownell, Hongliang Wang, Chaomin Li, Xiaxia Meng, Ling Yuan, Haiyan Liu, Sijin Li, Jun Xie Source Type: research
[99mTc]Tc-duramycin, a potential molecular probe for early prediction of tumor response after chemotherapy
Apoptosis plays a crucial role in many biological processes, especially in cancer. However, real-time monitoring of apoptosis is challenging. [99mTc]duramycin can selectively target an apoptosis biomarker: phosphatidylethanolamine (PE), which is normally located on the intracellular cell-membrane surface but redistributes onto the outer cell-membrane upon apoptosis. Therefore, 99mTc-duramycin is a potential probe for non-invasive detection of apoptosis in real-time. The aim of this study was to evaluate the value of [99mTc]duramycin for detecting early apoptotic response in tumors after chemotherapy, thus providing a tool ...
Source: Nuclear Medicine and Biology - August 9, 2018 Category: Nuclear Medicine Authors: Yi Li, Cheng Liu, Xiaoping Xu, Xiaoling Lu, Jianming Luo, Brian Gray, Koon Y. Pak, Jingyi Cheng, Yingjian Zhang Source Type: research
[99mTc]duramycin, a potential molecular probe for early prediction of tumor response after chemotherapy
Apoptosis plays a crucial role in many biological processes, especially in cancer. However, real-time monitoring of apoptosis is challenging. [99mTc]duramycin can selectively target an apoptosis biomarker: phosphatidylethanolamine (PE), which is normally located on the intracellular cell-membrane surface but redistributes onto the outer cell-membrane upon apoptosis. Therefore, 99mTc-duramycin is a potential probe for non-invasive detection of apoptosis in real-time. The aim of this study was to evaluate the value of [99mTc]duramycin for detecting early apoptotic response in tumors after chemotherapy, thus providing a tool ...
Source: Nuclear Medicine and Biology - August 9, 2018 Category: Nuclear Medicine Authors: Yi Li, Cheng Liu, Xiaoping Xu, Xiaoling Lu, Jianming Luo, Brian Gray, Koon Y. Pak, Jingyi Cheng, Yingjian Zhang Source Type: research
Effects of adding an albumin binder chain on [177Lu]Lu-DOTATATE
[177Lu]Lu-DOTATATE peptide receptor radionuclide therapy is used for treatment of neuroendocrine tumours. We investigated whether prolonging blood residence time of [177Lu]Lu-DOTATATE with albumin binders could increase tumour accumulation and tumour-to-kidney ratios for improved therapeutic efficacy. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - August 9, 2018 Category: Nuclear Medicine Authors: Etienne Rousseau, Joseph Lau, Zhengxing Zhang, Carlos F. Uribe, Hsiou-Ting Kuo, Chengcheng Zhang, Jutta Zeisler, Nadine Colpo, Kuo-Shyan Lin, Fran çois Bénard Source Type: research
One-pot enzymatic synthesis of L-[3-11C]lactate for pharmacokinetic analysis of lactate metabolism in rat brain
Lactate could serve as an energy source and signaling molecule in the brain, although there is insufficient in vivo evidence to support this possibility. Here we aimed to use a one-pot enzymatic synthetic procedure to synthesize L-[3-11C]lactate that can be used to evaluate chemical forms in the blood after intravenous administration, and as a probe for pharmacokinetic analysis of lactate metabolism in in vivo positron emission tomography (PET) scans with normal and fasted rats. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - July 7, 2018 Category: Nuclear Medicine Authors: Takashi Temma, Hidekazu Kawashima, Naoya Kondo, Makoto Yamazaki, Kazuhiro Koshino, Hidehiro Iida Source Type: research
Preclinical study of an 18F-labeled glutamine derivative for Cancer imaging
The emerging evidence that demonstrated the extra-demand of glutamine for cancer surviving strongly called for the development of PET tracer for imaging glutamine uptake in cancer. In this work, [18F]Gln-BF3 as a natural glutamine derivative was synthesized to explore its potential application of imaging glutamine uptake for cancer diagnosis. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - July 6, 2018 Category: Nuclear Medicine Authors: Cong Li, Hui Liu, Dongban Duan, Zhenhan Zhou, Zhibo Liu Source Type: research
Improving metabolic stability of fluorine-18 labeled verapamil analogs
Fluorine-18 labeled positron emission tomography (PET) tracers were developed to obtain more insight into the function of P-glycoprotein (P-gp) in relation to various conditions. They allow research in facilities without a cyclotron as they can be transported with a half-life of 110 min. As the metabolic stability of previously reported tracers [18F]1 and [18F]2 was poor, the purpose of this study was to improve this stability using deuterium substitution, creating verapamil analogs [18F]1-d4, [18F]2-d4, [18F]3-d3 and [18F]3-d7. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - July 4, 2018 Category: Nuclear Medicine Authors: Renske M. Raaphorst, Gert Luurtsema, Cindy J. Schokker, Khaled A. Attia, Robert C. Schuit, Philip H. Elsinga, Adriaan A. Lammertsma, Albert D. Windhorst Source Type: research
Fluorine-18 labeled diphenyl sulfide derivatives for imaging serotonin transporter (SERT) in the brain
Serotonin transporters (SERT) play an important role in controlling serotonin concentration in the synaptic cleft and in managing postsynaptic signal transduction. Inhibitors of SERT binding are well known as selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine, sertraline, paroxetine, and escitalopram, that are commonly prescribed antidepressants. Positron emission tomography (PET) and single photon emission tomography (SPECT) imaging agents targeting SERT may be useful for studying its function and providing a tool for monitoring drug treatment. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - July 3, 2018 Category: Nuclear Medicine Authors: Yan Zhang, Futao Liu, Hao Xiao, Xinyue Yao, Genxun Li, Seok Rye Choi, Karl Ploessl, Zhihao Zha, Lin Zhu, Hank F. Kung Source Type: research
[18F]diphenyl sulfide derivatives for imaging serotonin transporter (SERT) in the brain
Serotonin transporters (SERT) play an important role in controlling serotonin concentration in the synaptic cleft and in managing postsynaptic signal transduction. Inhibitors of SERT binding are well known as selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine, sertraline, paroxetine, and escitalopram, that are commonly prescribed antidepressants. Positron emission tomography (PET) and single photon emission tomography (SPECT) imaging agents targeting SERT may be useful for studying its function and providing a tool for monitoring drug treatment. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - July 3, 2018 Category: Nuclear Medicine Authors: Yan Zhang, Futao Liu, Hao Xiao, Xinyue Yao, Genxun Li, Seok Rye Choi, Karl Ploessl, Zhihao Zha, Lin Zhu, Hank F. Kung Source Type: research
Influence of transport line material on the molar activity of cyclotron produced [18F]fluoride
Production of fluorine-18 –labeled radiopharmaceuticals is always associated with the varying levels of the same compound containing stable fluorine-19. In practice, this affects the molar activity (Am), defined as amount of radioactivity divided by the molar quantity (Bq/mol).We have focused on studying how the material o f the transport tubing connecting the cyclotron target chamber to the synthesis device affects the concentration of fluoride in the water arriving to the reaction vessel and subsequently the Am of the fluorine-18 labeled radiopharmaceuticals produced. (Source: Nuclear Medicine and Biology)
Source: Nuclear Medicine and Biology - July 2, 2018 Category: Nuclear Medicine Authors: Nina Savisto, J örgen Bergman, Jussi Aromaa, Sarita Forsback, Olli Eskola, Tapio Viljanen, Johan Rajander, Stefan Johansson, Julian Grigg, Sajinder Luthra, Olof Solin Source Type: research
