Dynamic TSPO-PET for assessing early effects of cerebral hypoxia and resuscitation in new born pigs

Inflammation associated with microglial activation may be an early prognostic indicator of perinatal hypoxic ischemic injury, where translocator protein (TSPO) is a known inflammatory biomarker. This piglet study used dynamic TSPO-PET with [18F]GE180 to evaluate if microglial activation after global perinatal hypoxic injury could be detected.

Source: Nuclear Medicine and Biology - August 24, 2018 Category: Nuclear Medicine Authors: Charlotte de Lange, R ønnaug Solberg, Jon Erik Holtedahl, Andreas Tulipan, Jon Barlinn, William Trigg, Torild Wickstrøm, Ola Didrik Saugstad, Eirik Malinen, Mona Elisabeth Revheim Source Type: research