Improving metabolic stability of fluorine-18 labeled verapamil analogs

Fluorine-18 labeled positron emission tomography (PET) tracers were developed to obtain more insight into the function of P-glycoprotein (P-gp) in relation to various conditions. They allow research in facilities without a cyclotron as they can be transported with a half-life of 110 min. As the metabolic stability of previously reported tracers [18F]1 and [18F]2 was poor, the purpose of this study was to improve this stability using deuterium substitution, creating verapamil analogs [18F]1-d4, [18F]2-d4, [18F]3-d3 and [18F]3-d7.

Source: Nuclear Medicine and Biology - July 4, 2018 Category: Nuclear Medicine Authors: Renske M. Raaphorst, Gert Luurtsema, Cindy J. Schokker, Khaled A. Attia, Robert C. Schuit, Philip H. Elsinga, Adriaan A. Lammertsma, Albert D. Windhorst Source Type: research