99mTc-3PRGD2 scintigraphy to stage liver fibrosis and evaluate reversal after fibrotic stimulus withdrawn

Today, it is well accepted that partial or complete regression of liver fibrosis and even cirrhosis can be potentially achieved if the underlying etiology of the disease is suppressed or the anti-fibrotic strategies employed are effective [1,2]. Accurate evaluation of liver fibrosis severity is critical for developing a timely treatment plan that may prevent or postpone fibrotic progression, or even reverse fibrogenesis [3]. To date, the histological examination of a liver biopsy (LB) specimen remains the “gold standard” for clinically evaluating the severity of liver fibrosis.
Source: Nuclear Medicine and Biology - Category: Nuclear Medicine Authors: Source Type: research