Radiosynthesis and biological evaluation of N-(2-[18F]Fluoropropionyl)-3,4-dihydroxy-L-phenylalanine as a PET tracer for oncologic imaging

Several 11C and 18F labelled 3,4-dihydroxy-L-phenylalanine (L-DOPA) analogues have been used for neurologic and oncologic diseases, especially for brain tumors and neuroendocrine tumors PET imaging. However, 18F –labeled N-substituted L-DOPA analogues have not been reported so far. In the current study, radiosynthesis and biological evaluation of a new 18F–labeled L-DOPA analogue, N-(2-[18F]Fluoropropionyl)-3,4-dihydroxy-L-phenylalanine ([18F]FPDOPA) for tumor PET imaging are performed.

Source: Nuclear Medicine and Biology - April 7, 2017 Category: Nuclear Medicine Authors: Caihua Tang, Dahong Nie, Ganghua Tang, Siyuan Gao, Shaoyu Liu, Fuhua Wen, Xiaolan Tang Source Type: research