Iminodiacetic Acid as Bifunctional Linker for Dimerization of Cyclic RGD Peptides

In this study, I2P –RGD2 was used as the example to illustrate a novel approach for dimerization of cyclic RGD peptides. The main objective of this study was to explore the impact of bifunctional linkers (glutamic acid vs. iminodiacetic acid) on tumor-targeting capability and excretion kinetics of the 99mTc-labeled dimeric cyclic RGD peptides.
Source: Nuclear Medicine and Biology - Category: Nuclear Medicine Authors: Source Type: research