PET Imaging of 64Cu-DOTA-scFv-Anti-PSMA Lipid Nanoparticles (LNPs): Enhanced Tumor Targeting over Anti-PSMA scFv or Untargeted LNPs

Single chain (scFv) antibodies are ideal targeting ligands due to their modular structure, high antigen specificity and affinity. These monovalent ligands display rapid tumor targeting but have limitations due to their fast urinary clearance.

Source: Nuclear Medicine and Biology - January 15, 2017 Category: Nuclear Medicine Authors: Patty Wong, Lin Li, Junie Chea, Melissa K. Delgado, Desiree Crow, Erasmus Poku, Barbara Szpikowska, Nicole Bowles, Divya Channappa, David Colcher, Jeffrey Y.C. Wong, John E. Shively, Paul J. Yazaki Source Type: research