18F –Fluoro-2-deoxyglucose PET informs neutrophil accumulation and activation in lipopolysaccharide-induced acute lung injury

Molecular imaging of the earliest events related to the development of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) could facilitate therapeutic development and patient management. We previously reported that 18F –fluoro-2-deoxyglucose (18F–FDG) PET identifies ALI/ARDS prior to radiographic abnormalities. The purpose of this study was to establish the time courses of 18F–FDG uptake, edema and neutrophil recruitment in an endotoxin-induced acute lung injury model and to examine molecular events required for 14C-2DG uptake in activated neutrophils.

Source: Nuclear Medicine and Biology - January 15, 2017 Category: Nuclear Medicine Authors: Rosana S. Rodrigues, Fernando A. Bozza, Christopher J. Hanrahan, Li-Ming Wang, Qi Wu, John M. Hoffman, Guy A. Zimmerman, Kathryn A. Morton Source Type: research