From micro ‐ to macro‐structures in multiple sclerosis: what is the added value of diffusion imaging
NMR in Biomedicine, EarlyView. (Source: NMR in Biomedicine)
Source: NMR in Biomedicine - January 19, 2018 Category: Radiology Source Type: research
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NMR in Biomedicine, Ahead of Print. (Source: NMR in Biomedicine)
Source: NMR in Biomedicine - January 19, 2018 Category: Radiology Source Type: research
Diffusion tensor imaging MRI of sickle cell kidney disease: initial results and comparison with iron deposition
Chronic kidney disease (CKD) occurs in over one‐third of patients with sickle cell disease (SCD) and can progress to end‐stage renal disease. Unfortunately, current clinical assessments of kidney function are insensitive to early‐stage CKD. Previous studies have shown that diffusion magnetic resonance imaging (MRI) can sensitively detect regional renal microstructural changes associated with early‐stage CKD. However, previous MRI studies in patients with SCD have been largely limited to the detection of renal iron deposition assessed by T2* relaxometry. In this pilot imaging study, we compare MRI assessments of ren...
Source: NMR in Biomedicine - January 19, 2018 Category: Radiology Authors: Shannon B. Donnola, Connie M. Piccone, Lan Lu, Joshua Batesole, Jane Little, Katherine M. Dell, Chris A. Flask Tags: RESEARCH ARTICLE Source Type: research
Issue Information
No abstract is available for this article. (Source: NMR in Biomedicine)
Source: NMR in Biomedicine - January 18, 2018 Category: Radiology Tags: ISSUE INFORMATION Source Type: research
Cover Image, Volume 31, Issue 2
The cover image, by Mikheil Gogiashvili et al., is based on the Research Article Impact of intratumoral heterogeneity of breast cancer tissue on quantitative metabolomics using high‐resolution magic angle spinning 1H NMR spectroscopy, DOI: 10.1002/nbm.3862. (Source: NMR in Biomedicine)
Source: NMR in Biomedicine - January 18, 2018 Category: Radiology Authors: Mikheil Gogiashvili, Salome Horsch, Rosemarie Marchan, Kathrin Gianmoena, Cristina Cadenas, Berno Tanner, Sabrina Naumann, Diana Ersova, Frank Lippek, J örg Rahnenführer, Jan T. Andersson, Roland Hergenröder, Jörg Lambert, Jan G. Hengstler, Karolina E Tags: COVER IMAGE Source Type: research
The effects of ageing on mouse muscle microstructure: a comparative study of time ‐dependent diffusion MRI and histological assessment
In this study, we investigated hind‐limb muscles of young growing and mature healthy mice using diffusion‐weighted imaging protocols and histology. Imaging findings showed that muscle water diffusivity decreased with increasing mouse age both in vivo and in vitro. However, muscle fibre size was larger in older mice, whereas the extracellular matrix decreased with age. This suggests that muscle water diffusivity may be driven by different sarcolemma‐associated properties between actively growing myofibres and adult myofibres in homeostasis. (Source: NMR in Biomedicine)
Source: NMR in Biomedicine - January 9, 2018 Category: Radiology Authors: Paola Porcari, Matt G. Hall, Chris A. Clark, Elizabeth Greally, Volker Straub, Andrew M. Blamire Tags: EDITOR ’S PICK Source Type: research
Expanded neurochemical profile in the early stage of Huntington disease using proton magnetic resonance spectroscopy
The striatum is a well‐known region affected in Huntington disease (HD). However, other regions, including the visual cortex, are implicated. We have identified previously an abnormal energy response in the visual cortex of patients at an early stage of HD using 31P magnetic resonance spectroscopy (31P MRS). We therefore sought to further characterize these metabolic alterations with 1H MRS using a well‐validated semi‐localized by adiabatic selective refocusing (semi‐LASER) sequence that allows the measurement of an expanded number of neurometabolites. Ten early affected patients [Unified Huntington Disease Rating ...
Source: NMR in Biomedicine - January 9, 2018 Category: Radiology Authors: Isaac M. Adanyeguh, Marie ‐Lorraine Monin, Daisy Rinaldi, Léorah Freeman, Alexandra Durr, Stéphane Lehéricy, Pierre‐Gilles Henry, Fanny Mochel Tags: RESEARCH ARTICLE Source Type: research
Can T1w/T2w ratio be used as a myelin ‐specific measure in subcortical structures? Comparisons between FSE‐based T1w/T2w ratios, GRASE‐based T1w/T2w ratios and multi‐echo GRASE‐based myelin water fractions
This study reports on the feasibility of using T2‐weighted (T2w) images extracted from multi‐echo three‐dimensional gradient and spin echo (3D GRASE) sequences for T1w/T2w ratio mapping, and evaluates how T1w/T2w ratios perform as a myelin‐specific measure in human brain. Our findings suggest that both fast spin echo (FSE)‐ and GRASE‐based T1w/T2w approaches measure similar facets of subcortical tissue microstructure, but do not appear to be specific to myelin. T1w/T2w ratios and myelin water fractions (MWFs) appear to be sensitized to different microstructural properties, thereby providing two separate measure...
Source: NMR in Biomedicine - January 9, 2018 Category: Radiology Authors: Md Nasir Uddin, Teresa D. Figley, Ruth Ann Marrie, Chase R. Figley, Tags: RESEARCH ARTICLE Source Type: research
Multiband diffusion ‐weighted MRI of the eye and orbit free of geometric distortions using a RARE‐EPI hybrid
This study shows that diffusion‐weighted RARE‐EPI has the capability to acquire high fidelity, distortion‐free images of the eye and the orbit. It is shown that RARE‐EPI maintains the immunity to B0 inhomogeneities reported for RARE imaging. This benefit can be exploited for the assessment of ocular masses and pathological changes of the eye and the orbit.
This study shows that diffusion‐weighted rapid acquisition with relaxation enhancement‐echo planar imaging (RARE‐EPI) has the capability to acquire distortion‐free images of the eye and orbit with ample diffusion contrast. The results underpin the challe...
Source: NMR in Biomedicine - January 9, 2018 Category: Radiology Authors: Katharina Paul, Till Huelnhagen, Eva Oberacker, Daniel Wenz, Andr é Kuehne, Helmar Waiczies, Sebastian Schmitter, Oliver Stachs, Thoralf Niendorf Tags: RESEARCH ARTICLE Source Type: research
Proton change of parotid glands after gustatory stimulation examined by magnetic resonance imaging
The aim of this study was to investigate proton changes of the parotid gland after gustatory stimulation by semi‐quantitative parameters and an empirical mathematical model (EMM) using high‐temporal‐resolution, double‐echo, echo‐planar imaging (EPI). Approved by a local institutional review board, this study examined 20 parotid glands from 10 healthy volunteers (male:female = 6: 4; age ± standard deviation =35.1 ± 14.1 years) with written informed consent obtained. All participants underwent 1.5‐T, double‐echo EPI with gustatory stimulation. Semi‐quantitative parameters, including maximal drop ratio (MDR...
Source: NMR in Biomedicine - January 8, 2018 Category: Radiology Authors: Yi ‐Jui Liu, Yi‐Hsiung Lee, Hing‐Chiu Chang, Hui‐Chu Chiu, Ta‐Wei Chiu, Kang Hsu, Cheng‐Ming Pen, Hsian‐He Hsu, Chun‐Jung Juan Tags: RESEARCH ARTICLE Source Type: research
Development of manganese ‐enhanced magnetic resonance imaging of the rostral ventrolateral medulla of conscious rats: Importance of normalization and comparison with other regions of interest
Spinally projecting neurons in the rostral ventrolateral medulla (RVLM) are believed to contribute to pathophysiological alterations in sympathetic nerve activity and the development of cardiovascular disease. The ability to identify changes in the activity of RVLM neurons in conscious animals and humans, especially longitudinally, would represent a clinically important advancement in our understanding of the contribution of the RVLM to cardiovascular disease. To this end, we describe the initial development of manganese‐enhanced magnetic resonance imaging (MEMRI) for the rat RVLM. Manganese (Mn2+) has been used to estim...
Source: NMR in Biomedicine - January 1, 2018 Category: Radiology Authors: Daniel J. Huereca, Konstandinos A. Bakoulas, Farhad Ghoddoussi, Bruce A. Berkowitz, Avril Genene Holt, Patrick J. Mueller Tags: RESEARCH ARTICLE Source Type: research
Apparent diffusion coefficients in prostate cancer: correlation with molecular markers Ki ‐67, HIF‐1α and VEGF
In conclusion, ADC was correlated with PSA, GS, and Ki‐67, HIF‐1α and VEGF expression in patients with PCa. ADC may be used to evaluate tumor proliferation, hypoxia and angiogenesis in PCa.
The apparent diffusion coefficient (ADC) was correlated with prostate‐specific antigen (PSA), Gleason score (GS), and Ki‐67, hypoxia‐inducible factor‐1α (HIF‐1α) and vascular endothelial growth factor (VEGF) expression in patients with prostate cancer (PCa). These findings suggest that ADC may be used as an imaging biomarker to evaluate tumor proliferation, hypoxia and angiogenesis in PCa. (Source: NMR in Biomedicine)
Source: NMR in Biomedicine - January 1, 2018 Category: Radiology Authors: Teng Ma, Shaolin Yang, Haiyan Jing, Lin Cong, Zhixin Cao, Zhiling Liu, Zhaoqin Huang Tags: RESEARCH ARTICLE Source Type: research
Sub ‐minute kinetics of human red cell fumarase: 1H spin‐echo NMR spectroscopy and 13C rapid‐dissolution dynamic nuclear polarization
Fumarate is an important probe of metabolism in hyperpolarized magnetic resonance imaging and spectroscopy. It is used to detect the release of fumarase in cancer tissues, which is associated with necrosis and drug treatment. Nevertheless, there are limited reports describing the detailed kinetic studies of this enzyme in various cells and tissues. Thus, we aimed to evaluate the sub‐minute kinetics of human red blood cell fumarase using nuclear magnetic resonance (NMR) spectroscopy, and to provide a quantitative description of the enzyme that is relevant to the use of fumarate as a probe of cell rupture. The fumarase rea...
Source: NMR in Biomedicine - January 1, 2018 Category: Radiology Authors: Dmitry Shishmarev, Alan J. Wright, Tiago B. Rodrigues, Giuseppe Pileio, Gabriele Stevanato, Kevin M. Brindle, Philip W. Kuchel Tags: RESEARCH ARTICLE Source Type: research
A comparison of 2 ‐hydroxyglutarate detection at 3 and 7 T with long‐TE semi‐LASER
In this study, a comparison using semi‐localization by adiabatic selective refocusing (semi‐LASER) (TE = 110 ms) at 3 T and 7 T reveals significantly improved 2‐HG Cramér–Rao lower bounds (CRLBs) in patients with glioma, together with improvement in the pairwise fitting correlation with γ‐aminobutyric acid (GABA) at 7 T. The superior spectral profile at 7 T allowed for the detection (CRLB < 20%) of 2‐HG after two acquired transients compared with ~64 at 3 T. (Source: NMR in Biomedicine)
Source: NMR in Biomedicine - January 1, 2018 Category: Radiology Authors: Adam Berrington, Natalie L. Voets, Sarah J. Larkin, Nick Pennington, James Mccullagh, Richard Stacey, Christopher J. Schofield, Peter Jezzard, Stuart Clare, Tom Cadoux ‐Hudson, Puneet Plaha, Olaf Ansorge, Uzay E. Emir Tags: RAPID COMMUNICATION Source Type: research
Investigation of the BOLD and CBV fMRI responses to somatosensory stimulation in awake marmosets (Callithrix jacchus)
Understanding the spatiotemporal features of the hemodynamic response function (HRF) to brain stimulation is essential for the correct application of neuroimaging methods to study brain function. Here, we investigated the spatiotemporal evolution of the blood oxygen level‐dependent (BOLD) and cerebral blood volume (CBV) HRF in conscious, awake marmosets (Callithrix jacchus), a New World non‐human primate with a lissencephalic brain and with growing use in biomedical research. The marmosets were acclimatized to head fixation and placed in a 7‐T magnetic resonance imaging (MRI) scanner. Somatosensory stimulation (333...
Source: NMR in Biomedicine - December 29, 2017 Category: Radiology Authors: Yoshiyuki Hirano, Cecil C. Yen, Junjie V. Liu, Julie B. Mackel, Hellmut Merkle, George C. Nascimento, Bojana Stefanovic, Afonso C. Silva Tags: RESEARCH ARTICLE Source Type: research
